A5103111101- Renal cell carcinoma treatment
- Renal and related cancers
- Cancer Genomics and Diagnostics
- Genetic and Kidney Cyst Diseases
- Cancer and Skin Lesions
- Medical Imaging and Pathology Studies
- Urinary and Genital Oncology Studies
- Bladder and Urothelial Cancer Treatments
- Urologic and reproductive health conditions
- Breast Lesions and Carcinomas
- Soft tissue tumor case studies
- Salivary Gland Tumors Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Sarcoma Diagnosis and Treatment
- Renal Diseases and Glomerulopathies
- Oral and Maxillofacial Pathology
- Ovarian cancer diagnosis and treatment
- Tuberous Sclerosis Complex Research
- Metastasis and carcinoma case studies
- Dermatological and Skeletal Disorders
- Chromatin Remodeling and Cancer
- Cancer Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Cancer, Hypoxia, and Metabolism
- Vascular Tumors and Angiosarcomas
Japanese Red Cross Kochi Hospital
2012-2022
Kinan Hospital
2022
Charles University
2007-2021
Virginia Commonwealth University
2019
Rush University Medical Center
2018
Columbia College - Missouri
2018
Red Cross Hospital
2007-2017
University of Miyazaki
2017
University of Miyazaki Hospital
2017
Creative Research Enterprises (United States)
2017
Abstract BACKGROUND: Several promising molecular‐targeted drugs are used for advanced renal cancers. However, complete remission is rarely achieved, because none of the targets a key molecule that specific to cancer, or associated with “oncogene addiction” (dependence on one few oncogenes cell survival) cancer. Recently, an anaplastic lymphoma kinase (ALK) fusion, vinculin‐ALK, has been reported in pediatric carcinoma (RCC) cases who have history sickle trait. In this context, ALK inhibitor...
Birt-Hogg-Dubé syndrome (BHD) is a rare genetic disorder characterized by fibrofolliculomas, pulmonary cysts and renal cell carcinomas (RCCs). The affected individuals inherit germline mutations in the folliculin gene (FLCN). We investigated mutation spectrum clinicopathologic findings of 312 patients from 120 different families (119 Japanese 1 Taiwanese). A total 31 FLCN sequence variants were identified. majority c.1285dupC (n = 34), c.1533_1536delGATG 25), c.1347_1353dupCCACCCT 19)....
To evaluate the clinical outcomes and histological types of renal cell carcinoma (RCC) arising in patients with end-stage disease (ESRD), to analyse relationship histopathological features duration dialysis.Clinical characteristics 34 who had a radical nephrectomy for RCC ESRD between November 1994 June 2008 were investigated. Archive paraffin-embedded tissue specimens obtained from 27 histochemically immunohistochemically analysed determine type.There was one death cancer patient local...
Birt-Hogg-Dubé (BHD) syndrome is an autosomal dominant disorder characterized by fibrofolliculomas, renal tumors, and pulmonary cysts with recurrent pneumothorax. Multiple pneumothorax are the key signs for diagnosing BHD syndrome. The pathologic features of cysts, however, poorly understood. This caused mutations in gene that encodes folliculin (FLCN). FLCN regarded as a tumor suppressor; it mediates cellular activities interacting mammalian target rapamycin (mTOR). In this study, we...
We present a series of 14 cases cutaneous hidradenocarcinomas. The patients included 6 women and 8 men ranging in age at diagnosis from 34 to 93 years. All but 1 patient presented with solitary nodule. There was no predilection site. One multiple lesions representing metastatic nodules. Of 12 available follow-up, 2 died disease, whereas the remaining 10 were alive 3 them experienced local recurrence course disease. Grossly, tumors ranged size 1.2 cm. Microscopically, primary tumors, 9 showed...
Anaplastic lymphoma kinase (ALK) translocation renal cell carcinomas (RCCs) have been reported by several independent groups in recent times. The clinical behavior and histopathologic characteristics of these are not fully understood because the paucity cases reported. Here, we describe 2 RCC harboring a novel striatin (STRN)-ALK fusion. first case was 33-year-old woman with no sickle trait who underwent nephrectomy for right mass had late recurrence para-aortic lymph nodes twice 10 12 years...
Renal cell carcinoma (RCC) associated with Xp11.2 translocation (TFE3-RCC) has been recently defined as a distinct subset of RCC classified by characteristic morphology and clinical presentation. The Xp11 translocations involve the TFE3 transcription factor produce chimeric proteins retaining basic helix-loop-helix leucine zipper structure for dimerization DNA binding suggesting that function oncogenic factors. Diagnostic biomarkers effective forms therapy advanced cases TFE3-RCC are yet...
Mucinous tubular and spindle cell carcinoma (MTSCC) of the kidney generally shows low nuclear grade. MTSCC with high grade is relatively rare. In this article, we report two cases Fuhrman 3. One case occurred in a 57-year-old Japanese female second 49-year-old Caucasian female. Histologically, tumors were composed neoplastic cells cuboidal or columnar morphology, The myxoid stroma was also observed. This positive for Alcian blue stain. Immunohistochemically, both AMACR, but negative CD10 RCC...
Abstract Mixed epithelial and stromal tumor of the kidney is a rare benign that consists both cells. To date, eight malignant cases have previously been reported in female patients only. We report first case mixed male patient. A 67‐year‐old Japanese man receiving hormonal therapy for prostatic cancer was found to right renal cystic underwent nephrectomy. Histologically, composed cells addition undifferentiated Immunohistochemically, component positive cluster differentiation 99 B ‐cell...