Mucinous tubular and spindle cell carcinoma with Fuhrman nuclear grade 3: a histological, immunohistochemical, ultrastructural and FISH study.

• DOI: 10.14670/hh-23.1517
• Publication Date: 2008-12-01
• Authors: Naoto Kuroda; Ondřej Hes; Michael Michal; Jana Němcová; Viliam Gál; Takeshi Yamaguchi; Takako Kawada; Yasushi Imamura; Yoshihiro Hayashi; G H Lee
• Keywords: Stain

Mucinous tubular and spindle cell carcinoma (MTSCC) of the kidney generally shows low nuclear grade. MTSCC with high grade is relatively rare. In this article, we report two cases Fuhrman 3. One case occurred in a 57-year-old Japanese female second 49-year-old Caucasian female. Histologically, tumors were composed neoplastic cells cuboidal or columnar morphology, The myxoid stroma was also observed. This positive for Alcian blue stain. Immunohistochemically, both AMACR, but negative CD10 RCC Ma. Ultrastructurally, tumorous one contained numerous mitochondria. FISH analysis, many demonstrated monosomy chromosomes 15 22 disomy 7 17. patients died respiratory failure due to pleuritis carcinomatosa 48 months postoperatively. Finally, pathologist should recognize that exists despite its rare frequency. analysis may be helpful establishing diagnosis entity. Furthermore, present first patient dying distant metastasis.