A5101555859- Cancer Treatment and Pharmacology
- Breast Cancer Treatment Studies
- HER2/EGFR in Cancer Research
- Chemotherapy-related skin toxicity
- Gastric Cancer Management and Outcomes
- Genetic factors in colorectal cancer
- Pancreatic and Hepatic Oncology Research
- Cancer survivorship and care
- Sperm and Testicular Function
- Cardiomyopathy and Myosin Studies
- Breast Lesions and Carcinomas
- Venous Thromboembolism Diagnosis and Management
- Vasculitis and related conditions
- Colorectal Cancer Surgical Treatments
- Parasitic Diseases Research and Treatment
- Non-Invasive Vital Sign Monitoring
- Cancer Genomics and Diagnostics
- Neuroblastoma Research and Treatments
- Colorectal Cancer Screening and Detection
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Hair Growth and Disorders
- Optical Imaging and Spectroscopy Techniques
- Liver Disease Diagnosis and Treatment
- Breast Implant and Reconstruction
- Advanced Breast Cancer Therapies
Toranomon Hospital
2022-2025
Dokkyo Medical University
2013-2025
Hirosaki University
1988-2025
Hokkaido University Hospital
2025
Hokkaido University
2024
Sapporo University
2024
Health Sciences University of Hokkaido
2024
Center for Environmental Health
2024
International University of Health and Welfare
2021-2023
Musashino Red Cross Hospital
2014-2020
Purkinje fibers in mammalian hearts are known to comprise the following three groups depending on their structure: group I found commonly ungulates, II humans, monkeys and dogs, III rodents. The aim of present study was document precisely cytoarchitecture a network different species by light electron microscopy. Light microscopy silver impregnated tissues revealed reticular ensheathing individual strands consisting 2-8 cells both ungulates (i.e., sheep goats) cetaceans (whales dolphins)...
Objectives: Further metastasis should be avoided in pancreatic cancer (PC) patients for effective surgical treatment. Regulatory T cells (Foxp3+CD4+ including CD4+CD25+ and CD4+CD25− cells) play important roles tumor immunity. This study aimed to investigate whether regulatory participate metastasis. Methods: Peripheral blood was withdrawn from PC patients, as well healthy volunteer donors controls. The peripheral mononuclear (PBMCs) were subjected FACScan analysis after labeling with...
Abstract Background In the WHO 2010 classification, neuroendocrine tumors (NETs) are subdivided by their mitotic index or Ki67 into either G1 G2 NETs. Tumors with a of <2% classified as and those 3—20% G2. However, assessment greater than 2% less equal to 3% is still unclear. To resolve problem, we validated criteria gastrointestinal NETs classification. Methods The medical records 45 patients who were pathologically diagnosed having NET G1/G2 tract analyzed retrospectively. According...
The Purkinje fibers are located in the ventricular walls of heart, just beneath endocardium and conduct excitation from right left bundle branches to myocardium. Recently, anatomists succeeded photographing a sheep, which clearly showed mesh structure fibers. In this study, we present technique for modeling semiautomatically using an extended L-system. L-system is formal grammar that defines growth fractal by generating rules (or rewriting rules) initial structure. It was originally...
Mucinous tubular and spindle cell carcinoma (MTSCC) of the kidney generally shows low nuclear grade. MTSCC with high grade is relatively rare. In this article, we report two cases Fuhrman 3. One case occurred in a 57-year-old Japanese female second 49-year-old Caucasian female. Histologically, tumors were composed neoplastic cells cuboidal or columnar morphology, The myxoid stroma was also observed. This positive for Alcian blue stain. Immunohistochemically, both AMACR, but negative CD10 RCC...
Abstract Hand-foot skin reaction (HFSR) is a common adverse effect of vascular endothelial growth factor receptor (VEGFR) inhibitors that significantly impacts patients’ quality life. Prevention and management HFSR require individualized approaches, but risk factors remain unclear. This study aimed to develop artificial intelligence (AI) models predict grade ≥ 2 using clinical data foot sole images from 93 instances VEGFR inhibitor administration in 76 patients. Image-based,...
Introduction: Antemortem diagnosis of pulmonary tumor thrombotic microangiopathy (PTTM) is challenging because rapidly worsening respiratory failure. Vascular endothelial growth factor (VEGF) involved in PTTM pathogenesis; however, the clinical picture patients with cancer receiving anti-VEGF treatment unknown. Case Presentation: A 40-year-old man advanced gastric adenocarcinoma on paclitaxel plus ramucirumab developed a dry cough and, after two months stable period, dyspnea exertion. Chest...
1504 Background: Trastuzumab deruxtecan (T-DXd) is a highly effective agent for HER2-positive metastatic breast cancer (MBC), but associated with adverse events such as nausea, fatigue, and interstitial lung disease. Based on recent studies showing that symptom monitoring alert notifications via ePROs could improve patient quality of life (QoL) prognosis, we hypothesized employing this method may diminish the treatment burden patients receiving T-DXd. Methods: In multicenter, randomized...
Crohn's disease (CD) has various clinical manifestations, including anal fistulae and perianal abscesses. While abscesses typically occur during infancy, pediatricians should remain alert to the possibility of CD when appear outside usual age onset. We report case a three-year-old boy with refractory fistulas who exhibited no gastrointestinal symptoms or growth failure at presentation. Gastrointestinal endoscopy revealed significant mucosal abnormalities, but histopathological examination...
1545 Background: The PRO-DUCE study (jRCTs031200387), a multicenter, randomized controlled study, evaluated the impact of ePRO plus body temperature (BT)/SpO 2 monitoring (ePROm) vs.usual care (UC) on quality life (QoL) for patients (pts) with HER2-positive metastatic breast cancer (MBC) treated T-DXd. primary results presented at ASCO 2024 showed that week 24, ePROm demonstrated better global health status (GHS) vs. UC. Based recent studies showing symptom and alert notifications via ePROs...
Human epidermal growth factor (HER) 2-directed therapy is the standard treatment for HER2-positive breast cancer. Patients who achieved a pathological complete response (pCR) to are associated with excellent disease-free survival. However, few molecular markers available predict pCR. Here, we aimed establish DNA methylation marker trastuzumab and chemotherapy. A total of 67 patients were divided into screening (n = 21) validation 46) sets. Genome-wide analysis set identified eight genomic...
<b><i>Objective:</i></b> Resistance to trastuzumab is a problem that remains be solved in HER2-positive breast cancer. We aimed characterize profiles of genetic and epigenetic alterations cancer-related pathways cancers, using biopsy tissue samples obtained from patients enrolled prospective neoadjuvant clinical trial. <b><i>Methods:</i></b> cancer were collected processed with the PAXgene Tissue System. A total 24 cancers analyzed. Genetic 409...
Abstract HER2-positive breast cancers that achieve pathological complete response (pCR) after HER2-directed therapy consistently have good survival. We previously identified HSD17B4 methylation as a marker for pCR by screening. Here, we aimed to identify new conducting multi-omics analysis of materials prepared laser capture microdissection, and adding 71 samples. In the screening set (n = 36), mutations, methylation, expression were analyzed targeted sequencing, Infinium 450 K, microarray,...
Background: Heavy metals such as lead (Pb) and cadmium (Cd) have been associated with adverse pregnancy developmental outcomes, including congenital abnormalities. This study investigated the association between exposure to heavy trace elements during fetal life limb abnormalities in infants.
Abstract Background The effectiveness of a therapeutic strategy that switches chemotherapy, based on Ki-67 tumour expression after initial therapy, relative to standard has not been evaluated. Methods Patients were randomly assigned the control arm or response-guided (Ki-67 arm). Primary biopsies obtained before treatment, and three once-weekly doses paclitaxel trastuzumab assess interim index. In arm, continued for total 12 doses, regardless subsequent treatment was early responder is...
The causal agents of gastric cancer could include fungus toxins. Sterigmatocystin (ST), a toxin, is risk factor cancer. We investigated the effects ST on stomach tissues Mongolian gerbils.
Although parasites of the genus Trichinella have been collected from wild animals in Japan, they never studied at species level. Muscle larvae a black bear (Ursus thibetanus japonicus) and raccoon dog (Nyctereutes procyonoides viverrinus) Japan identified as britovi by random amplified polymorphic DNA analysis. The presence T. shows that this parasite has wide distribution Palaearctic region, western Europe to eastern Asia, isotherm -6 C January could be considered its northern border.
exhibits hereditary deficiency in albumin biosynthesis.Serum bilirubin concentration is rather lower homozygous (aa) rats (0.009 f 0.002 mg/dl) as compared with heterozygous (Aa) (0.047 0.009 or wild-type Sprague-Dawley (AA) (0.034 0.006 evidenced by high pressure liquid chromatography analysis of bilirubin.After intravenous administration various amounts [heme-'HJhemoglobin rats, [3H]bilirubin derived from [3H]heme hemoglobin vivo more efficiently excreted into bile aa than Aa AA...