A5071627021- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Renal cell carcinoma treatment
- Bladder and Urothelial Cancer Treatments
- Asthma and respiratory diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Renal and related cancers
- Inhalation and Respiratory Drug Delivery
- Prostate Cancer Diagnosis and Treatment
- Multiple and Secondary Primary Cancers
- Lung Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Urinary Bladder and Prostate Research
- Urological Disorders and Treatments
- COVID-19 diagnosis using AI
- Cancer Immunotherapy and Biomarkers
- Cancer Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Urinary and Genital Oncology Studies
- Testicular diseases and treatments
- Ureteral procedures and complications
- Nutrition and Health in Aging
- Pediatric health and respiratory diseases
- Radiomics and Machine Learning in Medical Imaging
- Pneumothorax, Barotrauma, Emphysema
Kyoto University
2009-2025
Shizuoka General Hospital
2024
Kobe University
2018-2024
Kitano Hospital
2016-2022
Kyoto College of Medical Science
2022
Hyogo Prefectural Cancer Center
2019
Hyogo Medical University
2012-2018
Kobe City Medical Center General Hospital
2006-2016
Keio University
2015
Tokyo Women's Medical University
2011
Anaplastic lymphoma kinase (ALK) translocation renal cell carcinomas (RCCs) have been reported by several independent groups in recent times. The clinical behavior and histopathologic characteristics of these are not fully understood because the paucity cases reported. Here, we describe 2 RCC harboring a novel striatin (STRN)-ALK fusion. first case was 33-year-old woman with no sickle trait who underwent nephrectomy for right mass had late recurrence para-aortic lymph nodes twice 10 12 years...
Abstract Background Interstitial lung abnormalities (ILAs) on CT may affect the clinical outcomes in patients with chronic obstructive pulmonary disease (COPD), but their quantification remains unestablished. This study examined whether artificial intelligence (AI)-based segmentation could be applied to identify ILAs using two COPD cohorts. Methods were diagnosed visually based Fleischner Society definition. Using an AI-based method, ground-glass opacities, reticulations, and honeycombing...
Coronary artery calcification (CAC) detected through chest computed tomography (CT) strongly predicts cardiovascular events in asymptomatic individuals undergoing primary prevention. Few studies with limited sample sizes have investigated the predictive value of CAC for complications COVID-19. This study examined impact on using a large-scale COVID-19 database. multicenter retrospective cohort used data from Japan Task Force After exclusion based missing information, 1,109 patients were...
ABSTRACT Background Chest computed tomography (CT) is a valuable tool for diagnosing and predicting the severity of coronavirus disease 2019 (COVID‐19) assessing extrapulmonary organs. Reduced muscle mass visceral fat accumulation are important features body composition phenotype in which obesity loss coexist, but their relationship with COVID‐19 outcomes remains unclear. In this study, we aimed to investigate association between erector spinae (ESM) epicardial adipose tissue (EAT) ratio...
Using a photoaffinity labeling technique, Nakamaru-Ogiso et al. demonstrated that fenpyroximate, strong inhibitor of bovine heart mitochondrial NADH-ubiquinone oxidoreductase (complex I), binds to the ND5 subunit [Nakamaru-Ogiso, E., (2003) Biochemistry 42, 746-754]. Considering main body composed transmembrane helixes 1-15 is located at distal end membrane domain [Efremov, R. G., (2010) Nature 465, 441-445], however, their result may be questionable. Because establishing number and location...
Physiological and prognostic associations of centrilobular emphysema (CLE) paraseptal (PSE) in smokers with without chronic obstructive pulmonary disease (COPD) have been increasingly recognized, but the extrapulmonary abnormalities, such as muscle wasting, osteoporosis, cardiovascular diseases, remain unestablished.The aim study was to investigate whether CLE associated abnormalities independent concomitant PSE airflow limitation.This retrospective consecutively enrolled current limitation...
Dysanapsis, a mismatch between airway tree caliber and lung size, contributes to large variation in function on spirometry healthy subjects. However, it remains unclear whether other morphological features of the could be associated with independent dysanapsis. This study used cancer screening chest computed tomography (CT) data from asymptomatic never smokers. Dysanapsis complexity geometry were quantified CT by measuring ratio (ALR) fractal dimension (AFD). Moreover, total count (TAC),...
Chest computed tomography (CT) is used to screen for lung cancer and evaluate pulmonary extra-pulmonary abnormalities such as emphysema coronary artery calcification, particularly in smokers. In real-world practice, are visually assessed using high-contrast thin-slice images which generated from raw scan data sharp reconstruction kernels with the sacrifice of increased image noise. contrast, accurate CT quantification requires low-contrast low noise, soft kernels. However, only sharp-kernel...
Background Low respiratory function in young adulthood is one of the important factors trajectory leading to future development COPD, but its morphological characteristics are not well characterised. Methods We retrospectively enrolled 172 subjects aged 40–49 years with ≥10 pack-years smoking history who underwent lung cancer screening by computed tomography (CT) and spirometry at two Japanese hospitals. Emphysema was visually assessed according Fleischner Society guidelines classified into...
Abstract In patients with chronic obstructive pulmonary disease (COPD), emphysema, airway disease, and extrapulmonary comorbidities may cause various symptoms impair physical activity. To investigate the relative associations of manifestations activity in symptomatic patients, this study enrolled 193 COPD who underwent chest inspiratory/expiratory CT completed assessment test (CAT) Life-Space Assessment (LSA) questionnaires to evaluate symptom (CAT ≥ 10, n = 100), emphysema on inspiratory...
Centrilobular emphysema (CLE) and paraseptal (PSE) are observed in smokers with preserved ratio impaired spirometry (PRISm, defined as the of forced expiratory volume 1 s (FEV1) to vital capacity (FVC) ≥0.7 FEV1 <80%), but their prevalence physiological impacts remain unestablished. This multicentre study aimed investigate its test whether subtypes differently associated impairments PRISm. Both never- ever-smokers aged ≥40 years who underwent computed tomography (CT) for lung cancer...
Introduction Airway eosinophilic inflammation is a pathological feature in subgroup of patients with COPD and some smokers high risk. Although blood eosinophil count used to define COPD, the association between airway remains controversial. This cross-sectional study tested this without while considering potential confounders, such as smoking status comorbidities. Methods Lung specimens were obtained from non-COPD never-smokers undergoing lung lobectomy. Those any asthma history excluded....
Introduction: We aimed to clarify the therapeutic outcome of combination therapy using immune-checkpoint inhibitors (ICIs) and/or tyrosine kinase (TKIs) for metastatic non-clear-cell renal cell carcinoma (nccRCC). Methods: have been retrospectively investigating efficacy and prognosis in 36 patients with nccRCC undergoing two ICIs, ipilimumab plus nivolumab (ICI-ICI), ICI TKI (ICI-TKI), at Kobe University affiliated institutions since 2018. Progression-free survival (PFS), overall (OS),...
Abstract Background and Objective Mucus plugs underlying airway tree structure can affect airflow limitation prognosis in patients with chronic obstructive pulmonary disease (COPD), but their relative roles are unclear. This study used two COPD cohorts to examine whether mucus on computed tomography (CT) were associated clinical outcomes independent of other structural changes emphysema. Methods Based visual CT assessment, 0, 1–2 ≥3 lung segments assigned no‐, low‐ high‐mucus groups. Loss...
Lower skeletal muscle density may reflect adiposity and metabolic dysregulation that potentially impair disease control lung function independent of high body mass index (BMI) in patients with asthma. To investigate whether the lower pectoralis muscles (PMs) erector spinae (ESMs) on chest computed tomography was associated airway structural changes Consecutive asthma healthy controls undergoing were retrospectively analyzed. The ESM PM density, areas subcutaneous adipose tissue near...
In this work we propose Eu3+-doped YVO4 as a model compound of multimodal photoenergy converter that shows photoluminescence and photocatalytic activity discuss the relation between these two conversion modes. YVO4:Eu3+ nanoparticles with different Eu3+ concentrations distributions were prepared by coprecipitation ion exchange methods. The obtained samples consisted elliptical 20–25 nm in mean size, irrespective concentration distribution. showed converting functions under UV irradiation:...
The aim of the study is to clarify clinical effects first-line chemotherapy regimens for advanced urothelial cancer on responses and survival patients grouped by renal function. In this multicenter retrospective cohort study, 345 received systemic metastatic or unresectable disease in 17 centers (2004–10). Two hundred forty-one were treated with methotrexate, vinblastine, doxorubicin cisplatin/methotrexate, epirubicin cisplatin (n = 136) gemcitabine 105) followed carboplatin-based...