A5101567413- 3D Printing in Biomedical Research
- Pluripotent Stem Cells Research
- Asthma and respiratory diseases
- Vibration and Dynamic Analysis
- Structural Health Monitoring Techniques
- Process Optimization and Integration
- Infrastructure Maintenance and Monitoring
- Mesenchymal stem cell research
- Microfluidic and Bio-sensing Technologies
- Temporomandibular Joint Disorders
- Railway Engineering and Dynamics
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Fluid Dynamics and Vibration Analysis
- Microstructure and Mechanical Properties of Steels
- Innovative Microfluidic and Catalytic Techniques Innovation
- Fault Detection and Control Systems
- Thin-Film Transistor Technologies
- Target Tracking and Data Fusion in Sensor Networks
- Terahertz technology and applications
- Genetics, Aging, and Longevity in Model Organisms
- Innovative Teaching and Learning Methods
- Education and Learning Interventions
- Inhalation and Respiratory Drug Delivery
- Advanced ceramic materials synthesis
- Parkinson's Disease Mechanisms and Treatments
The University of Tokyo
2019-2025
Kyoto University
2019-2024
Kobe Steel (Japan)
2022-2024
Hiroshima University
2023-2024
Shizuoka University
2022
Kobelco Eco-Solutions (Japan)
2022
Kumamoto University
2021
Meijo University
2019-2021
Nagoya University
2021
Kindai University
2017-2021
Associations of fractional exhaled nitric oxide (FeNO) with airway wall remodeling and mucus plugs remain to be explored in smokers nonsmokers asthma. Ultra-high-resolution computed tomography (U-HRCT), which allows accurate structural quantification airways >1 mm diameter, was used this study examine whether higher FeNO associated thicker walls the 3rd 6th generation plugging patients The retrospective analyses included consecutive former asthma who underwent U-HRCT a hospital. ratio area...
Welding generates complex metal aerosols, inhalation of which is linked to adverse health effects among welders. An important concern welding fume (WF) exposure neurological dysfunction akin Parkinson's disease (PD), thought be mediated by manganese (Mn) in the fumes. Also, there a proposition that might accelerate onset PD. Our recent findings link presence Mn WF with dopaminergic neurotoxicity seen rats exposed manual arc-hard surfacing (MMA-HS) or gas arc-mild steel (GMA-MS) To elucidate...
Single-shot measurements of terahertz (THz) electric-field waveforms are demonstrated using a reflective echelon mirror, which produces multiple probe pulses with different time-delays. The polarization rotation the pulses, due to electro-optic effect induced by THz electric field generated from grating-coupled LiNbO3, was imaged onto two-dimensional complementary metal-oxide-semiconductor camera. A waveform weak peak strength 0.6 kV/cm obtained good signal-to-noise ratio, demonstrating...
Online collaborative learning (OCL) based on the community of inquiry (CoI) framework is often implemented in form an online discussion activity for teaching subjects that require learners to revise understandings and invent ways solve problems. However, implementing effective OCL such a purpose challenging due difficulty fostering higher-level stages, which indicate deeper learning. Such issue could hinder effectiveness might lead fewer transaction ideas. Prior studies showed facilitation...
This paper demonstrates the possibility to detect suspension failures of railway vehicles using a multiple-model approach from on-board measurement data. The vehicle model used includes lateral and yaw motions wheelsets bogie, motion body, with sensors measuring acceleration rate body. detection algorithm is formulated based on Interacting Multiple-Model (IMM) algorithm. IMM method has been applied for detecting faults in systems simulation study. mode probabilities states are estimated...
Abstract Background Macrophage-derived high mobility group box 1 (HMGB1), a damage-associated molecular pattern (DAMP) protein, plays key role in the development of chemotherapy-induced peripheral neuropathy (CIPN) caused by paclitaxel rodents. Endothelial thrombomodulin (TM) promotes thrombin-induced degradation HMGB1, and TMα, recombinant human soluble TM, abolishes HMGB1-induced allodynia mice. We thus examined whether particularly derived from macrophages, contributes to...
A novel control strategy for an active power filter that consists of a current-source PWM (pulse width modulation) converter and LC filters to eliminate the carrier frequency components is proposed in order obtain good harmonic compensation characteristics. The controlled with feedback loops input currents their derivatives suppress transient oscillations caused by without inserting damping resistors. Optimum values gains are investigated. cut-off optimum design about one seventh frequency,...
A kinetic study and model-based design space determination for drug substance flow synthesis using an amination reaction are presented. experiment was conducted to synthesize 3-fluoro-4-morpholinobenzonitrile from 3,4-difluorobenzonitrile, morpholine, diazabicycloundecene. Concentrations, residence time, temperature, reactor inner diameter were varied gather the data. set of equations defined describe mass energy balances, developed model could reproduce experimental profiles with high...
Lower skeletal muscle density may reflect adiposity and metabolic dysregulation that potentially impair disease control lung function independent of high body mass index (BMI) in patients with asthma. To investigate whether the lower pectoralis muscles (PMs) erector spinae (ESMs) on chest computed tomography was associated airway structural changes Consecutive asthma healthy controls undergoing were retrospectively analyzed. The ESM PM density, areas subcutaneous adipose tissue near...
This paper describes methods for fault detection of railway vehicles and tracks. We examine tracks using multi-resolution analysis into on-board measurement data as model-free approach. For vehicles, we adapt interacting multiple-model (IMM) algorithm model-based carried out simulation studies field tests with actual vehicle. The results suggest that track vehicle can be effectively detected by proposed method.
Diabetes is a major risk factor for atherosclerosis and ischemic vascular diseases. Recently, regenerative medicine expected to be novel therapy Our previous studies have reported that transplantation of stem cells promoted therapeutic angiogenesis diabetic neuropathy disease in paracrine manner, but the precise mechanism unclear. Therefore, we examined whether secreted factors from had direct beneficial effects on endothelial promote angiogenesis. The soluble were collected as conditioned...
A five-step method is proposed for determining the design space of mesenchymal stem cell (MSC) cultivation processes incorporating system dynamics and variabilities. The uses mechanistic models to capture MSC while performing stochastic simulation consider influences variabilities at raw material, cell, process specification, operation levels. Simulated time-dependent changes in critical quality attributes (CQAs) are used determine a dynamic probabilistic followed by global sensitivity...
This work presents hybrid modeling of an active pharmaceutical ingredient flow synthesis in a ring-opening reaction epoxide with Grignard reagent. Conducting this batch reactor is challenging due to its fast and highly exothermic nature, which makes it difficult collect kinetic data. To address this, experiment was conducted varying parameters, such as the inner diameter temperature, information. A one-dimensional mechanistic model then developed, two mechanisms were assessed, Swain Boyles...
Welding generates complex metal aerosols, inhalation of which is linked to adverse health effects among welders. An important concern welding fume (WF) exposure neurological dysfunction akin Parkinson's disease (PD), thought be mediated by manganese (Mn) in the fumes. Also, there a proposition that might accelerate onset PD. Our recent findings link presence Mn WF with dopaminergic neurotoxicity seen rats exposed manual arc-hard surfacing (MMA-HS) or gas arc-mild steel (GMA-MS) To elucidate...
Although diabetic polyneuropathy (DPN) is the commonest complication, its pathology remains to be clarified. As previous papers have suggested neuroprotective effects of glucagon-like peptide-1 in DPN, current study investigated physiological indispensability glucagon gene-derived peptides (GCGDPs) including peripheral nervous system (PNS). Neurological functions and neuropathological changes GCGDP deficient (gcg−/−) mice were examined. The gcg−/− showed tactile allodynia thermal...
A versatile numerical model for hydrogen absorption into metals was developed. Our addresses the kinetics of surface adsorption, subsurface transport (which plays an important role with active surfaces), and bulk diffusion processes. This can allow researchers to perform simulations various conditions, such as different material species, dimensions, structures, operating conditions. Furthermore, our calculation scheme reflects relationship between temperature changes in caused by heat...
Abstract This work presents an image‐based hybrid model incorporating the initial spatial distribution for mesenchymal stem cell (MSC) cultivation process design. First, three levels of seeding bias in static MSC were experimentally investigated, and resulting was quantified using phase contrast microscopy image analysis. Second, observed heterogeneity defined as a new parameter by calculating standard deviation seeded number fraction among numerical 8 × tiles on two‐dimensional plates....
Background Asthma is a heterogeneous disease with variable response to treatment. Genetic backgrounds are involved in the severity of type 2 asthma, but their effects on responses biologics remain unknown. This study aimed clarify role genetic factors patients severe asthma. Methods Adults asthma receiving were enrolled this multicentre, observational, real-world study. The evaluated using Physicians’ Global Evaluation Treatment Effectiveness (GETE). Optimal biologic for each patient was...