A5040776712- Renal cell carcinoma treatment
- Bladder and Urothelial Cancer Treatments
- Prostate Cancer Treatment and Research
- Cancer Immunotherapy and Biomarkers
- Renal and related cancers
- Cancer Genomics and Diagnostics
- Prostate Cancer Diagnosis and Treatment
- Urinary and Genital Oncology Studies
- Pancreatic and Hepatic Oncology Research
- Radiopharmaceutical Chemistry and Applications
- Epigenetics and DNA Methylation
- Cancer Diagnosis and Treatment
- Cancer-related gene regulation
- Urologic and reproductive health conditions
- Ferroptosis and cancer prognosis
- Bone health and treatments
- Urological Disorders and Treatments
- Esophageal Cancer Research and Treatment
- Genetic factors in colorectal cancer
- Economic and Financial Impacts of Cancer
- Neuroendocrine Tumor Research Advances
- Glioma Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Liver Diseases and Immunity
- Gastric Cancer Management and Outcomes
University of Occupational and Environmental Health Japan
2021-2024
Kobe University
2014-2023
Tottori University
2008-2023
Kobe University Hospital
2019-2021
Hokkaido University
1993-2017
Hokkaido University Hospital
2017
Tottori University Hospital
2014-2015
Tokyo Medical and Dental University
1988-2015
Tokyo National Hospital
2014
Yamaguchi University
2011
Subtype of urothelial carcinoma (SUC), defined here as with any histologic subtype or divergent differentiation, is a clinically aggressive disease. However, the efficacy enfortumab vedotin (EV) against SUC remains unclear. Hence, this study aimed to assess oncological outcomes patients treated EV for metastatic We retrospectively evaluated consecutive advanced lower and upper urinary tract cancer who received after platinum-based chemotherapy immune checkpoint blockade therapy at six...
None declared.
Abstract Initial rate kinetic studies of mitochondrial malate dehydrogenase, an enzyme previously shown to have a compulsory order mechanism (at pH 8.0 in 0.05 m Tris-acetate buffer), show that the zero maximum initial velocity and oxidized coenzyme dissociation constant (determined as product inhibitor) decrease concomitantly when ketomalonate is substituted for oxalacetate substrate. Since substrate or molecules are not present on intermediate complex from which dissociates...
VI-RADS: Multiinstitutional Multireader Diagnostic Accuracy and Interobserver Agreement StudyYoshiko Ueno, MD, PhD1, Tsutomu Tamada, PhD1,2, Mitsuru Takeuchi, PhD1,3, Keitaro Sofue, Satoru Takahashi, PhD1,4, Yuki Kamishima, PhD1,5, Yasuyo Urase, MD1, Ayumu Kido, PhD2, Nobuyuki Hinata, PhD6, Kenichi Harada, Masato Fujisawa, Yoshiyuki Miyaji, PhD7 Takamichi Murakami, PhD1Audio Available | Share
Background/Aim: This study retrospectively investigated the impact of enfortumab vedotin (EV) monotherapy on oncological outcome, safety profile, and health-related quality life (HRQoL) in patients with metastatic urothelial carcinoma. Patients Methods: We assessed 26 consecutive who had received EV after failure platinum-based chemotherapy immune checkpoint blockade therapy at our single institution from December 2021 to January 2023. The objective response rate (ORR), disease control...
Background/Aim: Variant urothelial carcinoma (VUC, defined herein as with any histological variant) is frequently observed at an advanced stage. However, the efficacy of systemic chemotherapy against VUC in metastatic disease has rarely been reported. This study assessed therapeutic response and survival outcomes platinum-based first-line treatment patients VUC. Patients Methods: We retrospectively analyzed consecutive bladder upper urinary tract cancer who received gemcitabine plus...
Abstract: Aims/Background : Transforming growth factor‐α (TGF‐α) is a potent mitogen of normal and neoplastic hepatocytes. In addition, TGF‐α has been reported to play pivotai role in hepatocarcinogenesis. To evaluate the significance chronic liver diseases hepatocellular carcinoma, we examined serum TGF‐α, expression epidermal factor receptor (EGFR) proliferating cell nuclear antigen (PCNA) mRNA tissues. Methods Thirty‐five patients with hepatitis (CH), 33 cirrhosis (LC), 55 carcinoma (HCC)...
Initial rate kinetic studies of pig heart mitochondrial malate dehydrogenase with substrate analogues hydroxymalonate and ketomalonate are reported. At 25° in pH 8.0, 0.05 ionic strength Tris acetate buffer, is reduced rapidly, half the turnover number observed physiological substrate. No appreciable oxidation could be observed. When oxidized or oxalacetate reduced, inhibits uncompetitively respect to competitively oxalacetate, suggesting that analogue binds enzyme-reduced coenzyme complex...
Objective Chronic hepatitis B virus (HBV) and C (HCV) infection may be involved in the development of cholangiocarcinoma. The prevalence HBV HCV was examined patients with intrahepatic cholangiocarcinoma (ICC) extrahepatic (ECC). Methods levels surface antigens (HBsAg), antibodies against core (HBcAb) (HCV-Ab) were determined sera obtained from 145 consecutive (50 ICC, 95 ECC). Results seroprevalence HBsAg 10% ICC 4.2% ECC patients. HCV-Ab 20% 7.4% Conclusion is 0.8-2.2% 1-2%, respectively,...
Glycyrrhizin (GL) is widely used in Japan as a therapeutic agent for chronic active liver diseases. However, its action on hepatocarcinogenesis remains to be elucidated. To clarify effect, mice treated with diethylnitrosamine (NDEA) or without GL were analyzed. Five-week-old male BALB/c divided into two groups, (n = 50) and C 47). Mice the group intramuscularly received 2 mg of 3 days week, same volume saline way. After weeks, an i.p. injection 75 mg/kg body wt NDEA weekly weeks 100...
This study aimed to clarify the impact of proton pump inhibitors (PPIs) on oncological outcomes in patients who received pembrolizumab for advanced urothelial carcinoma (UC).Forty UC treated with were retrospectively reviewed and divided into two groups (PPI: 15 patients; without PPI: 25 patients). Tumor response survival compared between these groups. The factors associated also investigated.The objective rate was significantly lower group PPIs PPIs. Both progression-free (PFS) overall (OS)...
Two methods are used to identify sarcopenia by calculating skeletal muscle area on computed tomography: the index (SMI) and psoas (PMI). Programmed death (PD)-1 inhibitors helpful in treating metastatic renal cell carcinoma (mRCC). However, there remains insufficient information regarding a clear easy-to-use biomarker for predicting response PD-1 patients with mRCC. Therefore, we investigated influence of clinical outcomes mRCC undergoing treatment nivolumab.This study evaluated 96 RCC who...
<h3>• Objective.</h3> —To evaluate the relationship of corpus callosum atrophy to cerebral cortical oxygen metabolism and cognitive function in patients with Alzheimer's disease. <h3>Design.</h3> —Prospective clinicoradiologic correlation magnetic resonance imaging positron emission tomography. <h3>Setting.</h3> —A university hospital. <h3>Patients, Participants.</h3> —Ten right-handed male disease, aged 46 70 years (mean±SD 57±6 years), 14 age- sex-matched control subjects. <h3>Main Outcome...
Objectives To clarify treatment patterns and outcomes for patients with unresectable or metastatic renal cell carcinoma in the molecular target therapy era Japan. Methods A multicenter, retrospective medical chart review study was carried out. Patients diagnosed between January 2012 August 2015 were enrolled. Data extracted from records included duration, grade ≥3 adverse events, reason discontinuation each targeted survival data until 2016. Results Of 277 eligible patients, 266, 170 77...