A5102955473- Bladder and Urothelial Cancer Treatments
- Cancer Immunotherapy and Biomarkers
- Dermatology and Skin Diseases
- Drug-Induced Adverse Reactions
- Cutaneous lymphoproliferative disorders research
- Prostate Cancer Treatment and Research
- Urinary and Genital Oncology Studies
- Autoimmune Bullous Skin Diseases
- Urticaria and Related Conditions
- Nail Diseases and Treatments
- Contact Dermatitis and Allergies
- T-cell and Retrovirus Studies
- Hair Growth and Disorders
- Psoriasis: Treatment and Pathogenesis
- Prostate Cancer Diagnosis and Treatment
- Eosinophilic Disorders and Syndromes
- Renal cell carcinoma treatment
- Radiopharmaceutical Chemistry and Applications
- Immune Cell Function and Interaction
- Urologic and reproductive health conditions
- Immunotherapy and Immune Responses
- Allergic Rhinitis and Sensitization
- Inflammatory Myopathies and Dermatomyositis
- Nonmelanoma Skin Cancer Studies
- Vector-Borne Animal Diseases
National Hospital Organization Kyushu Cancer Center
2016-2025
The University of Tokyo
2023
University of Occupational and Environmental Health Japan
2013-2022
Tokyo Medical University Hachioji Medical Center
2010-2014
Hamamatsu University School of Medicine
2012
Kishokai Medical Corporation
2010
The University of Kitakyushu
2010
Kyoto University
1995-2009
Suzuki (Japan)
2009
Ajinomoto (Japan)
2009
Abstract BACKGROUND: Melanoma tends to be refractory various immunotherapies because of tumor‐induced immunosuppression. To investigate the mechanism underlining immunosuppression melanoma patients, authors focused on programmed cell death‐1 (PD‐1)/PD‐1 ligand 1 (PD‐L1) interaction between tumor cells and T cells. METHODS: specimens were collected from 59 primary tumors, 16 lymph nodes, 4 lesions in‐transit metastasis. Specimens stained with anti‐PD‐L1 monoclonal antibodies digitalized jpg...
<h3>Objective</h3> To clarify the association of clinical and prognostic features with dermatomyositis (DM)-specific autoantibodies (Abs) in adult Japanese patients DM. <h3>Design</h3> Retrospective study. <h3>Setting</h3> Kanazawa University Graduate School Medical Science Department Dermatology collaborating medical centers. <h3>Patients</h3> A total 376 consecutive DM who visited our hospital or centers between 2003 2008. <h3>Main Outcome Measures</h3> Clinical laboratory characteristics...
We have developed an efficient in vitro class switching system using a subclone (CH12F3) of the IgM+ CH12.LX lymphoma cell line. CH12F3 cells switched from surface to IgA+ at high frequency (50%) after 72 h stimulation with IL-4, transforming growth factor (TGF)-beta and CD40L. No other isotype-producing were detected, indicating that clone is exclusively committed IgA isotype switching. To understand molecular basis commitment, we studied methylation profiles I region promoters...
Background.para-Cresol, which is present in the blood mainly as p-cresyl sulphate, a protein-bound uraemic toxin that produced intestine by certain intestinal bacteria, and its production affected various environmental factors. Patients with end-stage renal disease who are undergoing haemodialysis (HD) often have defective bowel function leading to abnormal defecation. Since treatment synbiotics (SYN), combination of probiotics prebiotics, reported improve habit, we examined effects SYN on...
Subtype of urothelial carcinoma (SUC), defined here as with any histologic subtype or divergent differentiation, is a clinically aggressive disease. However, the efficacy enfortumab vedotin (EV) against SUC remains unclear. Hence, this study aimed to assess oncological outcomes patients treated EV for metastatic We retrospectively evaluated consecutive advanced lower and upper urinary tract cancer who received after platinum-based chemotherapy immune checkpoint blockade therapy at six...
Acute generalized exanthematous pustulosis (AGEP) is a diffuse pustular disorder that usually begins in intertriginous folds with widespread erythema. The causes the majority of cases are drugs. T cells and interleukin (IL)-8 play roles development AGEP, but mechanism remains to be elucidated. We investigated involvement Th17 their cytokine IL-22 pathogenesis.Three patients AGEP were enrolled this study. percentages IL-17(+) cells, interferon γ(+) IL-4(+) measured patients' peripheral blood...
Abstract Male‐pattern hair loss ( MPHL , androgenetic alopecia) is a slowly progressive form of alopecia which begins after puberty. In 2010, we published the first Japanese edition guidelines for diagnosis and treatment . It achieved original goal providing physicians patients in Japan with evidence‐based information choosing efficacious safe therapy Subsequently, new therapeutic drugs methods have been developed, women's perception has undergone change term “female‐pattern FPHL )” becoming...
Objectives The JAVELIN Bladder 100 phase 3 trial showed that avelumab first‐line maintenance + best supportive care significantly prolonged overall survival and progression‐free versus alone in patients with advanced urothelial carcinoma who were following platinum‐based chemotherapy. We report findings from J‐AVENUE (NCT05431777), a real‐world study of therapy Japan. Methods Medical charts without disease progression chemotherapy, received between February November 2021, reviewed. Patients...
Background Two types of atopic dermatitis (AD) have been proposed, with different pathophysiological mechanisms underlying this seemingly heterogeneous disorder. The extrinsic type shows high IgE levels presumably as a consequence skin barrier damage and feasible allergen permeation, whereas the intrinsic exhibits normal is not mediated by allergen-specific IgE. Objectives To investigate relationship between pruritus perception threshold function patients AD in comparison types. Methods...
Background/Aim: This study retrospectively evaluated whether enfortumab vedotin (EV) monotherapy is effective as a late-line treatment according to prior type in patients with advanced urothelial carcinoma (UC). Patients and Methods: We assessed consecutive from the Uro-Oncology Group Kyushu population lower upper urinary tract cancer treated EV after platinum-based chemotherapy immune checkpoint inhibitor therapy failure between December 2021 March 2024. In particular, receiving avelumab...
Abstract Background Patient-reported quality of life is strongly affected by some dermatologic conditions. We developed a Japanese version the Dermatology Life Quality Index (DLQI-J) and used psychometric methods to examine its validity reliability. Methods The DLQI was created from original (English) version, using standard method. DLQI-J then completed 197 people, Some participants second time, 3 days later, reproducibility their responses. In addition DLQI-J, parts SF-36 gave data on...