A5054121299- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Liver Diseases and Immunity
- Pediatric Hepatobiliary Diseases and Treatments
- Metabolism and Genetic Disorders
- Liver Disease and Transplantation
- Hepatitis Viruses Studies and Epidemiology
- Drug Transport and Resistance Mechanisms
- Trace Elements in Health
- Organ Transplantation Techniques and Outcomes
- Neonatal Health and Biochemistry
- Diet and metabolism studies
- Systemic Lupus Erythematosus Research
- Animal Virus Infections Studies
- Parvovirus B19 Infection Studies
- Hemoglobinopathies and Related Disorders
- Amino Acid Enzymes and Metabolism
- Pancreatitis Pathology and Treatment
- Lysosomal Storage Disorders Research
- Viral Infections and Outbreaks Research
- Viral gastroenteritis research and epidemiology
- Mitochondrial Function and Pathology
- Heavy Metal Exposure and Toxicity
- Drug-Induced Hepatotoxicity and Protection
Saiseikai Yokohama Eastern Hospital
2014-2024
Kobe Asahi Hospital
2012-2022
Center for Assessment
2020
Tokyo Medical and Dental University
2017-2020
Nagoya University
2020
National Institute for Communicable Diseases
2020
Hanmi Pharmaceutical (South Korea)
2020
Otsuka (Japan)
2020
Kanagawa Children's Medical Center
2020
Toho University
2014-2019
Aims Although liver biopsy is crucial to diagnose and guide treatment decisions, a detailed histological analysis of autoimmune hepatitis (AIH) with clinically acute presentations has not yet been performed. This study aimed characterise the features explore potential hallmarks presentation AIH. Methods We systematically evaluated specimens 87 adult patients AIH retrospectively enrolled from Japanese multicentre facilities. Each feature was predefined by consensus based on diagnostic...
Abstract Background and Aims Chronic liver congestion reflecting right‐sided heart failure (RHF), Budd‐Chiari syndrome, or Fontan‐associated disease (FALD) is involved in fibrosis HCC. However, molecular mechanisms of HCC chronic remain poorly understood. Approach Results Here, we first demonstrated that promoted metastatic tumor growth using murine model by partial inferior vena cava ligation (pIVCL). As the initial step triggering promotion fibrosis, gut‐derived lipopolysaccharide (LPS)...
Background. Body fluids such as saliva, urine, sweat, and tears from hepatitis B virus (HBV) carriers are potential sources of HBV transmission. Methods. Thirty-nine children 8 adults who were chronically infected with enrolled. Real-time polymerase chain reaction was used for the quantification DNA. Results. DNA detected in 73.7% urine samples (14 19), 86.8% saliva (33 38), 100% tear (11 11), sweat (9 9). Mean levels (±SD) tears, 4.3 ± 1.1 log copies/mL, 5.9 1.2 6.2 0.7 5.2 0.6...
Primary sclerosing cholangitis (PSC) is a liver disease known for its frequent concurrence with inflammatory bowel disease. Dysbiosis of the gut microbiota in PSC was reported several studies, but microbiological features salivary have not been established. Here we compared microbial communities 24 pediatric-onset patients, 16 age-matched ulcerative colitis (UC) and healthy controls (HCs) by analyzing bacterial 16S rRNA gene sequence data. The species-richness (α-diversity) showed no...
Abstract Background Hepatocerebral mitochondrial DNA depletion syndrome (MTDPS) is a disease caused by defects in maintenance and leads to liver failure neurological complications during infancy. Liver transplantation (LT) remains controversial due poor outcomes associated with extrahepatic symptoms. The purposes of this study were clarify the current clinical molecular features hepatocerebral MTDPS evaluate LT patients Japan. Results We retrospectively assessed genetic findings, as well...
Congestive hepatopathy (CH) with chronic passive congestion is characterized by the progression of liver fibrosis without prominent inflammation and hepatocellular damage. Currently, lack reliable biomarkers for in CH often precludes clinical management patients CH. To explore biomarkers, we performed proteome analysis on serum exosomes isolated from after Fontan procedure. Exosomal cluster differentiation (CD)44 levels were increased compared to healthy volunteers was accompanied increases...
Abstract Background Drug‐induced liver injury (DILI) is a common adverse drug event with limited pediatric data in the literature. This study aimed to use electronic medical records assess hepatocellular DILI patients who were prescribed liver‐injury‐inducing drugs. Methods The Pediatric Medical Information Collection System (P‐MICS) centralized database integrating from over 40 centers. P‐MICS serum alanine aminotransferase (ALT) levels five or more times upper limit of normal and below 15...
Although many studies on the risk factors and their carcinogenesis in adult hepatocellular carcinoma (HCC) have been reported, they remain poorly understood childhood HCC. A retrospective study of 42 HCC cases Asian children was conducted. Hepatitis B virus (HBV)-DNA tissues detected 36 (86%) tested, while no hepatitis C (HCV)-RNA detectable any HCCs. Twenty (56%) were accompanied by cirrhosis. Surprisingly, very high prevalence HBV pre-S deletion mutant recognized 27 30 (90%) HCCs examined....
Although the diagnostic scoring system of autoimmune hepatitis (AIH) has been used, these criteria are intended mainly as research tools and complicated to apply. To resolve difficulties allow quick diagnosis, a simplified was proposed in 2007. We retrospectively compared AIH with 1999 revised original children.Twenty children (boys/girls 10/10, age 1-15 years, mean ± SD 8.4 4.4 years) who were diagnosed based on clinical, biochemical, immunological, histological data enrolled this study. In...
Aim: Non‐alcoholic steatohepatitis (NASH) has been classified pathologically into type 1 (characterized by ballooning and perisinusoidal fibrosis) 2 portal inflammation fibrosis). Reportedly, NASH the most commonly observed histopathological feature in pediatric non‐alcoholic fatty liver disease (NAFLD). While only a few studies have documented histopathology of NAFLD so far, appropriate classification or characteristics NAFLD, incidence correlation with race ethnicity are still...
Benign recurrent intrahepatic cholestasis type 2 (BRIC2) is caused by mutations in ABCB11, a gene encoding the bile salt export pump (BSEP) that mediates biliary secretion, and presents with repeated intermittent refractory itching. Currently, no effective medical therapy has been established. We previously provided experimental clinical evidence suggesting therapeutic potential of 4-phenylbutyrate (4PB) for cholestatic attacks BRIC2.After examining use 4PB treatment vitro studies, patient...
The Intractable Hepato-Biliary Disease Study Group of Japan, sponsored by the Ministry Health, Labor and Wealth, proposed in 2018 that patients with cirrhosis a Child-Pugh score 5-9 should be diagnosed as having acute-on-chronic liver failure (ACLF) when deterioration function ("serum bilirubin level 5.0 mg/dl or more" "prothrombin time value 40% less standardized values and/or international normalization rates 1.5 more") caused severe damage develops within 28 days after an acute insult,...
The authors have no conflict of interest.
Purpose Upregulation of type I interferon (IFN) signaling has been increasingly detected in inflammatory diseases. Recently, upregulation the IFN signature suggested as a potential biomarker IFN-driven Yet, it remains unclear to what extent is involved pathogenesis undifferentiated This study aimed quantify clinically undiagnosed patients and assess clinical characteristics those with high signature. Methods The was measured patients’ whole blood cells. Clinical biological data were...