A5087154046- Helicobacter pylori-related gastroenterology studies
- Galectins and Cancer Biology
- Liver Disease Diagnosis and Treatment
- Protein Tyrosine Phosphatases
- Viral Infections and Immunology Research
- Microbial Metabolites in Food Biotechnology
- Viral gastroenteritis research and epidemiology
- Liver physiology and pathology
- Escherichia coli research studies
- Sphingolipid Metabolism and Signaling
National Institute of Infectious Diseases
2019-2021
National Center for Global Health and Medicine
2021
Jikei University School of Medicine
2021
The University of Tokyo
2013-2018
Abstract Background and Aims Chronic liver congestion reflecting right‐sided heart failure (RHF), Budd‐Chiari syndrome, or Fontan‐associated disease (FALD) is involved in fibrosis HCC. However, molecular mechanisms of HCC chronic remain poorly understood. Approach Results Here, we first demonstrated that promoted metastatic tumor growth using murine model by partial inferior vena cava ligation (pIVCL). As the initial step triggering promotion fibrosis, gut‐derived lipopolysaccharide (LPS)...
Helicobacter pylori strains carrying the cagA gene are associated with severe disease outcomes, most notably gastric cancer. CagA protein is delivered into epithelial cells by a type IV secretion system. The translocated undergoes tyrosine phosphorylation at C-terminal EPIYA motifs host cell kinases. Tyrosine-phosphorylated acquires ability to interact and activate SHP2, thereby activating mitogenic signaling inducing morphological transformation (hummingbird phenotype). also interacts PAR1b...
Abstract Helicobacter pylori cagA -positive strains are critically involved in the development of gastric cancer. Upon delivery into epithelial cells via type IV secretion, -encoded CagA interacts with and thereby perturbs pro-oncogenic phosphatase SHP2 polarity-regulating kinase PAR1b tyrosine-phosphorylated EPIYA-C/D segment CM sequence, respectively. Importantly, sequences spanning these binding regions exhibit variations among proteins, which influence pathobiological/oncogenic potential...
Virus-like particles (VLPs) provide a well-established vaccine platform; however, the immunogenic properties acquired by VLP structure remain poorly understood. In this study, we showed that systemic vaccination with norovirus recalls human IgA responses at higher magnitudes than IgG under humanized mouse model was established introducing PBMCs in severely immunodeficient mice. The recall elicited vaccines depended on and disruption of attenuated responses, more profound reduction being...
Noroviruses (NoVs) are the leading cause of acute epidemic gastroenteritis in worldwide.Because extensive damages health and economics, development effective vaccines is strongly desired.Virus-like particles (VLPs) which self-assembled recombinantly expressed norovirus VP1 protein made as first generation vaccine candidate against norovirus.Since noroviruses known to infect through mucosal surface, induction IgA Abs by vaccination thought be beneficial provide more immunity.In this study, we...