A5077766409- HIV Research and Treatment
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- HIV/AIDS drug development and treatment
- Tuberculosis Research and Epidemiology
- Herpesvirus Infections and Treatments
- Pediatric health and respiratory diseases
- Immunodeficiency and Autoimmune Disorders
- Immune responses and vaccinations
- SARS-CoV-2 and COVID-19 Research
- Monoclonal and Polyclonal Antibodies Research
- Toxin Mechanisms and Immunotoxins
- HIV/AIDS Research and Interventions
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- RNA Research and Splicing
- Mycobacterium research and diagnosis
- Viral gastroenteritis research and epidemiology
- Cancer-related molecular mechanisms research
- Escherichia coli research studies
- Immune Response and Inflammation
- Cystic Fibrosis Research Advances
- interferon and immune responses
- RNA modifications and cancer
- COVID-19 Clinical Research Studies
The Ohio State University
2020-2025
Veer Surendra Sai Medical College and Hospital
2020
Shamnur Shivashankarappa Institute of Medical Sciences & Research Centre
2020
National Institute of Infectious Diseases
2019
Molecular mechanisms underlying inflammation-associated breast tumor growth are poorly studied. S100A7, a pro-inflammatory molecule has been shown to enhance cancer and metastasis. However, the S100A7-mediated molecular in enhancing metastasis unclear.Human tissue plasma samples were used analyze expression of cPLA2, PGE2. S100A7-overexpressing or downregulated human metastatic cells evaluate downstream signaling mechanisms. Bi-transgenic mS100a7a15 overexpression, TNBC C3 (1)/Tag...
5-methylcytosine (m 5 C) is one of the most prevalent modifications RNA, playing important roles in RNA metabolism, nuclear export, and translation. However, potential role m C methylation innate immunity remains elusive. Here, we show that depletion NSUN2, an methyltransferase, significantly inhibits replication gene expression a wide range DNA viruses. Notably, found this antiviral effect largely driven by enhanced type I interferon (IFN) response. The signaling pathway dependent on...
HIV-1 envelope glycoproteins (Envs) mediate viral entry and are sole target of neutralizing antibodies. Thus, Envs must maintain a delicate balance between evading antibodies while still preserving compatibility to into cells. Here, we studied the effeciency, fitness, replication an incompletely closed, transmitted/founder (CH040), which highly resistant most bnAbs. CH040 mediated cells as efficient other primary Envs, suggesting that antibody resistance can develop independently. Expression...
Abstract EZH2, a histone methyltransferase linked to poor outcomes in cancer, is overexpressed triple-negative breast cancer (TNBC), disproportionately affecting African-American and Hispanic women. EZH2 regulates the tumor immune microenvironment (TIME) by inhibiting MHC-I antigen presentation, upregulating PD-L1, leading reduced antitumor responses. Current inhibitors target its catalytic activity; however, development of resistance mechanisms cells frequently undermines their...
Significance We report that suppression of the serine protease elastase reshapes innate responses induced by injected vaccines containing alum adjuvant. This reprogramming improves induction protective antibodies in bloodstream and stimulates signals, which support development antibody mucosal tissues. Our findings identify as regulator blunts adjuvant activity alum. They also demonstrate vaccination via routes is not an absolute requirement for tissues secretions. Supplementation alum-based...
The vaccine Mycobacterium bovis Bacillus Calmette-Guérin (BCG) elicits an immune response that is protective against certain forms of tuberculosis (TB); however, because BCG efficacy limited it important to identify alternative TB candidates. Recently, the deletion mutant and candidate BCGΔBCG1419c was demonstrated survive longer in intravenously infected BALB/c mice due enhanced biofilm formation, better protected both C57BL/6 TB-induced lung pathology during chronic stages infection,...
Nontuberculous mycobacteria (NTM) are an increasingly common cause of respiratory infection in people with cystic fibrosis (PwCF). Relative to those no history NTM (CF-NTMNEG), PwCF and a (CF-NTMPOS) more likely develop severe lung disease experience complications over the course treatment. In other mycobacterial infections (e.g., tuberculosis), overexuberant immune response causes pathology compromises organ function; however, since profiles CF-NTMPOS CF-NTMNEG airways largely unexplored,...
Rhesus macaques are a critical animal model for preclinical testing of HIV-1 vaccine and prevention approaches. However, does not replicate in rhesus macaques, thus, chimeric simian-human immunodeficiency viruses (SHIVs), which encode envelope glycoproteins (Envs), used as surrogate challenge to infect modeling infection.
Virus-like particles (VLPs) provide a well-established vaccine platform; however, the immunogenic properties acquired by VLP structure remain poorly understood. In this study, we showed that systemic vaccination with norovirus recalls human IgA responses at higher magnitudes than IgG under humanized mouse model was established introducing PBMCs in severely immunodeficient mice. The recall elicited vaccines depended on and disruption of attenuated responses, more profound reduction being...
HIV-infected patients are at higher risk of developing oral mucosal infection and Epstein–Barr virus (EBV)-associated B cell malignancies. However, the potential role immunity in pathogenesis lesions is unknown. Tonsils oral-pharyngeal mucosal-associated lymphoid tissues that play an important immunity. In this study, we investigated changes innate adaptive immune cells macaque tonsils during chronic SIV infection. We found significantly frequencies classical monocytes, CD3+CD56+ (NKT-like)...
Anti-CD3-epsilon (CD3e) monoclonal antibodies (mAbs) and CD3e immunotoxins (ITs) are promising targeted therapy options for various T-cell disorders. Despite significant advances in mAb IT engineering, vascular leakage syndrome (VLS) remains a major dose-limiting toxicity ITs has been poorly characterized recent “engineered” mAbs. This study undertakes direct comparison of non-mitogenic CD3e-mAb (145-2C11 with Fc-silentTM murine IgG1: S-CD3e-mAb) new murine-version CD3e-IT...
Abstract Wild non-human primates carry many types of RNA viruses, including simian immunodeficiency virus (SIV), foamy virus, T-cell leukemia and hepatitis C virus. These viruses can also infect humans via zoonotic transmission through handling consumption primate bushmeat. Characterizing viral prevalence shedding in natural hosts is critical to understand infection risks within between species. Here, we sought identify a robust “field-friendly” method (i.e., without freezing or...
Simian immunodeficiency virus (SIV), which originated in African monkeys, crossed the species barrier into humans and ultimately gave rise to HIV global HIV/AIDS epidemic. While SIV infects over 40 primate sub-Saharan Africa, testing for RNA viruses wild populations can be challenging. Optimizing field-friendly methods assessing viral presence/abundance non-invasively collected biological samples facilitates study of viruses, including potentially zoonotic populations. This compares...
Infection of rhesus macaques with simian-human immunodeficiency viruses (SHIVs) is the preferred model system for vaccine development because SHIVs encode HIV-1 envelope glycoproteins (Env) – a key target neutralizing antibodies. Since goal vaccines to prevent new infections, encoding circulating Env are desired as challenge viruses. Development such biologically relevant has been challenging they fail infect macaques, mainly most do not use CD4 (rhCD4) receptor viral entry. Most primary...
Background: Schizophrenia is a commonest and one of the well known psychiatric disorders. Life expectancy patient with schizophrenia may be 20 to 30 years shorter than general population. Long term antipsychotic therapy usually required for management schizophrenia. It not currently possible predict which optimal given because there are still many debates about effectiveness efficacy atypical drugs over first generation antipsychotics. So, our aim assess various antipsychotics by using...
Abstract In recent years, the incidence of HIV has decreased, however it continues to spread globally. 70-90% individuals infected with develop oral mucosal infections. Interestingly, patients are at higher risk developing Epstein–Barr virus (EBV)-associated B cell malignancies in tonsils. However, potential role immunity pathogenesis lesions is unknown. Tonsils considered oral-pharyngeal associated lymphoid tissues and play an important immunity. detailed study human tonsillar immune cells...
Abstract CD3-epsilon(CD3e) immunotoxins (IT), a promising precision reagent for various clinical conditions requiring effective depletion of T cells, often shows limited treatment efficacy largely unknown reasons. Tissue-resident cells that persist in peripheral tissues have been shown to play pivotal roles local and systemic immunity, as well transplant rejection, autoimmunity cancers. The impact CD3e-IT on these however, remains poorly understood. Here, using new murine testing model, we...
CD3-epsilon(CD3e) immunotoxins (IT), a promising precision reagent for various clinical conditions requiring effective depletion of T cells, often shows limited treatment efficacy largely unknown reasons. Tissue-resident cells that persist in peripheral tissues have been shown to play pivotal roles local and systemic immunity, as well transplant rejection, autoimmunity cancers. The impact CD3e-IT on these however, remains poorly understood. Here, using new murine testing model, we...
Abstract The vaccine Mycobacterium bovis Bacillus Calmette–Guérin (BCG) elicits an immune response that is protective against certain forms of tuberculosis (TB); however, because BCG efficacy limited it important to identify alternative TB candidates. Recently, the deletion mutant and candidate BCGDBCG1419c was demonstrated survive longer in intravenously infected BALB/c mice due enhanced biofilm formation, better protected both C57BL/6 TB-induced lung pathology during chronic stages...