A5000445489- Immune Cell Function and Interaction
- Pediatric health and respiratory diseases
- Reproductive tract infections research
- Neonatal Respiratory Health Research
- Tuberculosis Research and Epidemiology
- Immune Response and Inflammation
- Gut microbiota and health
- Urinary Tract Infections Management
- IL-33, ST2, and ILC Pathways
- HIV/AIDS oral health manifestations
- Pneumonia and Respiratory Infections
Harvard University
2019-2025
The Ohio State University
2019-2023
As we age, there is an increased risk for the development of tuberculosis (TB) caused by Mycobacterium (Mtb) infection. Few studies consider that age-associated changes in alveolar lining fluid (ALF) may increase susceptibility altering soluble mediators innate immunity. We assessed impact adult or elderly human ALF during Mtb infection vitro and vivo. identified amplification pro-oxidative proinflammatory pathways decreased binding capability surfactant-associated surfactant protein A...
ABSTRACT Chlamydia trachomatis is an obligate intracellular bacterial pathogen that if left untreated can cause reproductive harm. Failure of natural adaptive immunity results in chronic and repeat infections. In efforts to understand the failure immunity, we have previously discovered CD8 + T cells, normally integral for controlling infections, are misprogrammed by PD-1/PD-L1 signaling during vivo C. infection fail mount a protective response. Seeking uncover pathways host factors involved...
HIV-infected patients are at higher risk of developing oral mucosal infection and Epstein–Barr virus (EBV)-associated B cell malignancies. However, the potential role immunity in pathogenesis lesions is unknown. Tonsils oral-pharyngeal mucosal-associated lymphoid tissues that play an important immunity. In this study, we investigated changes innate adaptive immune cells macaque tonsils during chronic SIV infection. We found significantly frequencies classical monocytes, CD3+CD56+ (NKT-like)...
Chlamydia trachomatis is the most commonly reported bacterial sexually transmitted infection in United States. Modeling animals can be challenging, as mice naturally clear C. when it deposited lower genital tract. However, productively infect tract bypassed and bacteria are directly into upper via transcervical inoculation. Interestingly, mouse-adapted species muridarum both by inoculation natural ascension if introduced vaginal vault. In this study, we investigated whether route of plays a...
Abstract In recent years, the incidence of HIV has decreased, however it continues to spread globally. 70-90% individuals infected with develop oral mucosal infections. Interestingly, patients are at higher risk developing Epstein–Barr virus (EBV)-associated B cell malignancies in tonsils. However, potential role immunity pathogenesis lesions is unknown. Tonsils considered oral-pharyngeal associated lymphoid tissues and play an important immunity. detailed study human tonsillar immune cells...