A5022709344- S100 Proteins and Annexins
- Immune cells in cancer
- Epigenetics and DNA Methylation
- Bladder and Urothelial Cancer Treatments
- Inflammation biomarkers and pathways
- Advanced Glycation End Products research
- Axon Guidance and Neuronal Signaling
- Cancer Immunotherapy and Biomarkers
- Phagocytosis and Immune Regulation
- Lung Cancer Research Studies
- Cancer Mechanisms and Therapy
- Chemokine receptors and signaling
- Neonatal Respiratory Health Research
- Planarian Biology and Electrostimulation
- Immune Response and Inflammation
- Inflammatory Biomarkers in Disease Prognosis
- Cancer-related Molecular Pathways
- Cancer, Stress, Anesthesia, and Immune Response
- Protease and Inhibitor Mechanisms
- Cancer, Lipids, and Metabolism
- Inflammatory mediators and NSAID effects
- Prostate Cancer Treatment and Research
- DNA Repair Mechanisms
- Macrophage Migration Inhibitory Factor
- Nuclear Receptors and Signaling
The Ohio State University
2015-2025
Indian Institute of Technology Jodhpur
2022-2024
The Ohio State University Wexner Medical Center
2014-2023
University of Utah
2011-2018
University of Nebraska Medical Center
2018
Ohio University
2016
Sanjay Gandhi Post Graduate Institute of Medical Sciences
2008-2011
Abstract RAGE is a multifunctional receptor implicated in diverse processes including inflammation and cancer. In this study, we report that expression upregulated widely aggressive triple-negative breast cancer (TNBC) cells, both primary tumors lymph node metastases. evaluating the functional contributions of cancer, found RAGE-deficient mice displayed reduced propensity for tumor growth. an established model lung metastasis, systemic blockade by injection neutralizing antibody inhibited...
Abstract Introduction Although C-X-C motif chemokine 12 (CXCL12) has been shown to bind receptor type 7 (CXCR7), the exact molecular mechanism regulations by CXCL12/CXCR7 axis in breast tumor growth and metastasis are not well understood. CXCR7 expression be upregulated during pathological processes such as inflammation cancer. Methods Breast cancer cell lines were genetically silenced or pharmacologically inhibited for and/or its downstream target signal transducer activator of...
Transient receptor potential vanilloid type-2 (TRPV2) is an ion channel that triggered by agonists like cannabidiol (CBD). Triple negative breast cancer (TNBC) aggressive disease with limited therapeutic options. Chemotherapy still the first line for treatment of TNBC patients; however, usually gains rapid resistance and unresponsiveness to chemotherapeutic drugs. In this study, we found TRPV2 protein highly up-regulated in tissues compared normal tissues. We also observed estrogen alpha...
Abstract Background Ibrutinib is a Bruton’s tyrosine kinase (BTK) and interleukin-2-inducible (ITK) inhibitor used for treating chronic lymphocytic leukaemia (CLL) other cancers. Although ibrutinib known to inhibit the growth of breast cancer cell in vitro, its impact on treatment metastasis unclear. Methods Using an orthotopic mouse model, we show that inhibits progression cancer. Results inhibited proliferation cells Ibrutinib-treated mice displayed significantly lower tumour burdens...
Abstract Triple-negative breast cancer (TNBC), defined as loss of estrogen, progesterone, and Her2 receptors, is a subtype highly aggressive with worse prognosis poor survival rate. Macrophage migration inhibitory factor (MIF) pleiotropic pro-inflammatory cytokine aberrantly expressed in many solid tumors known to promote tumor progression metastasis. However, its role TNBC metastasis unexplored. Here we have shown that patients, MIF expression was significantly enriched the compared...
Abstract Tumor-associated macrophages (TAM) are heterogeneous in nature and comprise antitumor M1-like (M1-TAM) or pro-tumor M2-like (M2-TAM) TAMs. M2-TAMs a major component of stroma breast tumors enhance metastasis by reducing their phagocytic ability increasing tumor fibrosis. However, the molecular mechanisms that regulate phenotypic plasticity TAMs not well known. Here we report novel suppressor Slit2 cancer regulating microenvironment. reduced vivo growth spontaneous syngeneic mammary...
Chemotherapy forms the backbone of current treatments for many patients with advanced non-small-cell lung cancer (NSCLC). However, survival rate is low in these due to development drug resistance, including cisplatin resistance. In this study, we developed a novel strategy combat growth cisplatin-resistant (CR) NSCLC cells. We have shown that treatment plant-derived, non-psychotropic small molecular weight molecule, cannabidiol (CBD), significantly induced apoptosis CR addition, CBD reduced...
Molecular mechanisms underlying inflammation-associated breast tumor growth are poorly studied. S100A7, a pro-inflammatory molecule has been shown to enhance cancer and metastasis. However, the S100A7-mediated molecular in enhancing metastasis unclear.Human tissue plasma samples were used analyze expression of cPLA2, PGE2. S100A7-overexpressing or downregulated human metastatic cells evaluate downstream signaling mechanisms. Bi-transgenic mS100a7a15 overexpression, TNBC C3 (1)/Tag...
// Mohamad Elbaz 1, 2 , Dinesh Ahirwar 1 Janani Ravi Mohd W. Nasser Ramesh K. Ganju Department of Pathology and The Comprehensive Cancer Center, Ohio State University, Wexner Medical Columbus, OH, USA Pharmacology, Pharmacy School, Helwan Helwan, Egypt Correspondence to: Ganju, email: Ramesh.ganju@osumc.edu Keywords: EGFR, IGF-IR, CNR2 Abbreviations: epidermal growth factor receptor (EGFR), insulin-like receptor-I (IGF-IR), estrogen (ER), cannabinoid receptor-2 (CNR2), matrix...
Epidemiological studies associate an increase in breast cancer risk, particularly triple-negative (TNBC), with lack of breastfeeding. This is more prevalent African American women, significantly lower rate breastfeeding compared to Caucasian women. Prolonged leads gradual involution (GI), whereas short-term or abrupt (AI) the breast. Our previous study utilizing a murine model demonstrated precancerous changes, specifically hyperplasia, non-obligate precursor mammary glands AI mice. Here we...
Targeting tumor angiogenesis is a promising alternative strategy for improvement of breast cancer therapy. Robo4 (roundabout homolog 4) signaling has been shown to protect endothelial integrity during sepsis shock and arthritis, inhibit Vascular Endothelial Growth Factor (VEGF) pathological retinopathy, which indicates that might be potential target in cancer. In this study, we used immune competent knockout mouse model show important suppressing growth metastasis. And effect does not...
Abstract Interactions between cells and their environment influence key physiologic processes such as propensity to migrate. However, directed migration controlled by extrinsically applied electrical signals is poorly understood. Using a novel microfluidic platform, we found that metastatic breast cancer sense respond the net direction of weak (∼100 µV cm −1 ), asymmetric, non-contact induced Electric Fields (iEFs). iEFs inhibited EGFR (Epidermal Growth Factor Receptor) activation, prevented...
Signal transducer and activator of transcription 1 (STAT1) mediates interferon gamma signaling which activates the expression various genes related to apoptosis, inflammation, cell cycle angiogenesis. Several experimental clinical studies have investigated role STAT1 in primary tumor growth breast cancer; however, its metastasis remains be determined. To determine cancer metastasis, we analyzed WT or STAT1−/− mice orthotopically implanted with metastatic 4T1.2 cells. Primary development was...
The association of interleukin-1β (IL-1B) -511C > T and IL-1 receptor antagonist (IL-1RN) VNTR, transforming growth factor-β (TGF-B1) +28C interferon-γ (IFN-G) + 874T>A polymorphisms with bladder cancer (CaB) susceptibility risk recurrence in Bacillus Calmette–Guérin (BCG)-treated patients was analyzed 287 controls 213 CaB (73 BCG treated). Increased observed the IL-1RN*2 allele (odds ratio (OR) 5.01) IFN-G +874 A (OR 1.78). TGF-B TT carriers were associated reduced (hazard (HR) 0.37)...
To investigate the association of tumour necrosis factor-alpha gene (TNF-alpha) polymorphisms T-1031C, C-863A, and C-857T with bladder cancer risk recurrence after bacille Calmette-Guérin (BCG) immunotherapy, as TNF-alpha regulates inflammatory process influencing susceptibility outcome BCG immunotherapy.In all, 220 patients 206 controls were recruited. Genotyping was done using allele specific-polymerase chain reaction.A CC genotype haplotype -1031C/-863C/-857T showed enhanced to cancer, an...