A5052635105- S100 Proteins and Annexins
- Chronic Myeloid Leukemia Treatments
- Inflammation biomarkers and pathways
- Advanced Glycation End Products research
- Chronic Lymphocytic Leukemia Research
- Neonatal Respiratory Health Research
- Axon Guidance and Neuronal Signaling
- Acute Myeloid Leukemia Research
- Immune cells in cancer
- Protease and Inhibitor Mechanisms
- Immune Cell Function and Interaction
- Cytokine Signaling Pathways and Interactions
- Calcium signaling and nucleotide metabolism
- Vascular Malformations Diagnosis and Treatment
- RNA Research and Splicing
- Inflammatory mediators and NSAID effects
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Cancer, Stress, Anesthesia, and Immune Response
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Intracranial Aneurysms: Treatment and Complications
- Hippo pathway signaling and YAP/TAZ
- Apelin-related biomedical research
- Cancer Mechanisms and Therapy
- Caveolin-1 and cellular processes
Medical College of Wisconsin
2021-2023
Versiti Blood Center of Wisconsin
2021-2023
German Cancer Research Center
2023
Heidelberg University
2023
American Society of Hematology
2023
University of Utah
2015-2022
The Ohio State University Wexner Medical Center
2012-2021
Huntsman Cancer Institute
2020-2021
Institute of Molecular Medicine
2017-2019
The Ohio State University
2012-2018
Abstract RAGE is a multifunctional receptor implicated in diverse processes including inflammation and cancer. In this study, we report that expression upregulated widely aggressive triple-negative breast cancer (TNBC) cells, both primary tumors lymph node metastases. evaluating the functional contributions of cancer, found RAGE-deficient mice displayed reduced propensity for tumor growth. an established model lung metastasis, systemic blockade by injection neutralizing antibody inhibited...
Abstract Introduction Although C-X-C motif chemokine 12 (CXCL12) has been shown to bind receptor type 7 (CXCR7), the exact molecular mechanism regulations by CXCL12/CXCR7 axis in breast tumor growth and metastasis are not well understood. CXCR7 expression be upregulated during pathological processes such as inflammation cancer. Methods Breast cancer cell lines were genetically silenced or pharmacologically inhibited for and/or its downstream target signal transducer activator of...
Abstract The secretory protein Slit2 and its receptors Robo1 Robo4 are considered to regulate mobility permeability of endothelial cells other cell types. However, the roles two in inflammatory responses remain be clarified. In this study, we show that, primary HUVECs, represses LPS-induced secretion certain cytokines/chemokines, adhesion molecule ICAM-1 upregulation, monocyte adhesion. Slit2’s anti-inflammatory effect is mediated by dominant endothelial-specific receptor Robo4. minor has...
// Catherine A. Powell 1 , Mohd W. Nasser Helong Zhao Jacob C. Wochna Xiaoli Zhang 2 Charles Shapiro 3 Konstantin Shilo and Ramesh K. Ganju Department of Pathology, The Ohio State University, Columbus, OH, USA Center for Biostatistics, Tisch Cancer Institute, Mount Sinai School Medicine, New York, Correspondence to: Ganju, email: Keywords : Fatty acid binding protein 5, triple negative breast cancer, epidermal growth factor receptor, degradation, metastasis Received December 16, 2014...
Objective: Current work has been designed to explore the abnormal expression of miRNAs in plasma samples patients with immune thrombocytopenic purpura (ITP) provide more guidance for clinical doctors. Methods: Bioinformatic analysis was performed using GSE80401 chip. The study subjects were recruited from First People's Hospital Lianyungang between May 2021 and December 2022. 48 ITP admitted intensive care unit finally enrolled. levels have examined real-time polymerase chain reaction...
The devastating sequelae of diabetes mellitus include microvascular permeability, which results in retinopathy. Despite clinical and scientific advances, there remains a need for new approaches to treat Here, we have presented possible treatment strategy, whereby targeting the small GTPase ARF6 alters VEGFR2 trafficking reverses signs pathology 4 animal models that represent features diabetic retinopathy fifth model ocular pathological angiogenesis. Specifically, determined same signaling...
Targeting tumor angiogenesis is a promising alternative strategy for improvement of breast cancer therapy. Robo4 (roundabout homolog 4) signaling has been shown to protect endothelial integrity during sepsis shock and arthritis, inhibit Vascular Endothelial Growth Factor (VEGF) pathological retinopathy, which indicates that might be potential target in cancer. In this study, we used immune competent knockout mouse model show important suppressing growth metastasis. And effect does not...
The activation of the small GTPase ARF6 has been implicated in promoting several pathological processes related to vascular instability and tumor formation, growth, metastasis. also plays a vital role during embryonic development. Recent studies have suggested that carries out these disparate functions primarily by controlling protein trafficking within cell. helps direct proteins intracellular or extracellular locations where they function normal cellular responses development later life....
Breakdown of the blood-central nervous system barrier (BCNSB) is a hallmark many neuroinflammatory disorders, such as multiple sclerosis (MS). Using mouse model MS, experimental autoimmune encephalomyelitis (EAE), we show that endothelial-to-mesenchymal transition (EndoMT) occurs in CNS before onset clinical symptoms and plays major role breakdown BCNSB function. EndoMT can be induced by an IL-1β-stimulated signaling pathway which activation small GTPase ADP ribosylation factor 6 (ARF6)...
Abstract Background Slit2 is a ~ 200 kDa secreted glycoprotein that has been recently shown to regulate immune functions. However, not much known about its role in HIV (human immunodeficiency virus)-1 pathogenesis. Results In the present study, we have N-terminal fragment of (Slit2N) (~120 kDa) inhibits replication both CXCR4 and CCR5-tropic HIV-1 viruses T-cell lines peripheral blood T-cells. Furthermore, demonstrated inhibition infection resting CD4+ addition, showed Slit2N blocks...
S100A7 (Psoriasin) is an inflammatory protein known to be upregulated in breast cancer. However, the role of cancer has been elusive, since both pro- and anti-proliferative roles have reported different types cells animal models. To date, mechanism by which differentially regulates cell proliferation still not clear. We used Gene Functional Enrichment Analysis search for determining factor differential regulation. confirmed elaborated its regulating using vitro culture. further verified...
The role of commensal bacterial microbiota in the pathogenesis human malignancies has been a research field incomparable progress recent years. Although breast tissue is commonly assumed to be sterile, studies suggest that may contain microbiota. In this study, we used an immune-competent orthotopic cancer mouse model explore existence unique and independent tumors. We observed some similarities with skin; however, tumor was mainly enriched Gram-negative bacteria, serving as primary source...
The chronic phase of myeloid leukemia (CP-CML) is characterized by the excessive production maturating cells. As CML stem/progenitor cells (LSPCs) are poised to cycle and differentiate, LSPCs must balance conservation differentiation avoid exhaustion, similar normal hematopoiesis under stress. Since BCR-ABL1 tyrosine kinase inhibitors (TKIs) eliminate differentiating but spare BCR-ABL1-independent LSPCs, understanding mechanisms that regulate LSPC may inform strategies LSPCs. Upon performing...
HIV-1 infection in T cells is regulated by TCR activation. However, the cellular proteins of pathway that regulate are poorly characterized. In this study, infection, we observed a significant reduction virus production Src homology 2 domain-containing leukocyte protein 76 kDa (SLP-76)-deficient Jurkat compared with wild-type and SLP-76-reconstituted cells. We further confirmed role SLP-76 small interfering RNA-mediated knockdown MT4 PBMCs. Structural-functional analysis revealed N-terminal...
Promoting intestinal epithelial regeneration remains a major medical challenge. Female patients taking nonsteroidal anti-inflammatory drugs are less likely to have upper gastrointestinal bleeding and ulcers than males. Using drug-induced damage mouse model, we verified that female mice recover faster males following acute insult. ex vivo organoid cultures, showed estrogen is necessary sufficient in enhancing the formation from breached isolated crypts via receptor β receptor. Thus, promotes...