A5051548428- Lung Cancer Treatments and Mutations
- S100 Proteins and Annexins
- Lung Cancer Research Studies
- Pancreatic and Hepatic Oncology Research
- Neonatal Respiratory Health Research
- Cancer Genomics and Diagnostics
- Lung Cancer Diagnosis and Treatment
- Cancer-related gene regulation
- Neuroendocrine Tumor Research Advances
- Peptidase Inhibition and Analysis
- Radiomics and Machine Learning in Medical Imaging
- Metastasis and carcinoma case studies
- Chromatin Remodeling and Cancer
- Inflammation biomarkers and pathways
- Occupational and environmental lung diseases
- Advanced Glycation End Products research
- Cancer Research and Treatments
- Gastric Cancer Management and Outcomes
- Myasthenia Gravis and Thymoma
- Mechanisms of cancer metastasis
- Cancer Mechanisms and Therapy
- PI3K/AKT/mTOR signaling in cancer
- Tracheal and airway disorders
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Medical Imaging and Pathology Studies
The Ohio State University Wexner Medical Center
2016-2025
The Ohio State University
2014-2024
The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute
2013-2020
National Cancer Institute
2011-2016
Cancer Genetics (United States)
2011-2016
Georgetown University Medical Center
2010-2016
Georgetown University
2010-2016
Ohio University
2012-2016
Mirna Therapeutics (United States)
2015
The University of Texas MD Anderson Cancer Center
2015
Although clinical studies have shown promise for targeting PD1/PDL1 signaling in non–small cell lung cancer (NSCLC), the regulation of PDL1 expression is poorly understood. Here, we show that regulated by p53 via miR-34. wild-type and p53-deficient lines (p53–/– p53+/+ HCT116, p53-inducible H1299, p53-knockdown H460) were used to determine if regulates miR-34a analyzed samples from patients with NSCLC mutated vs tumors The Cancer Genome Atlas Lung Adenocarcinoma (TCGA LUAD). We confirmed a...
Primary pulmonary and mediastinal synovial sarcoma is rare poses a diagnostic challenge particularly when unusual histological features are present. We present 60 cases of primary (29 male 27 female subjects; mean age, 42 years) compare our results with five prior series to better define features. Clinically, patients were younger gender bias. Radiologically, tumors well delineated distinctive magnetic resonance imaging little vascular enhancement. In all, 21/46 died disease within 5 years....
The eukaryotic translation initiation factor complex 4E (eIF4E) is downstream in the mammalian target of rapamycin (mTOR) pathway. This study explored expression eIF4E and its relationship with PTEN/AKT RAS/MEK/ERK pathways non-small cell lung carcinoma (NSCLC).The status phosphorylated (p-eIF4E), AKT (p-AKT), PTEN, tuberin (p-TSC2), mTOR (p-mTOR), S6 (p-S6), Erk1/2 (p-Erk1/2) was studied using immunohistochemical analysis applied to a tissue microarray containing 300 NSCLCs. Staining...
Abstract Non–small cell lung cancer (NSCLC) is the leading cause of deaths worldwide; however, only limited therapeutic treatments are available. Hence, we investigated role cannabinoid receptors, CB1 and CB2, as novel targets against NSCLC. We observed expression (24%) CB2 (55%) in NSCLC patients. Furthermore, have shown that treatment lines (A549 SW-1573) with CB1/CB2- CB2-specific agonists Win55,212-2 JWH-015, respectively, significantly attenuated random well growth factor-directed vitro...
Abstract RAGE is a multifunctional receptor implicated in diverse processes including inflammation and cancer. In this study, we report that expression upregulated widely aggressive triple-negative breast cancer (TNBC) cells, both primary tumors lymph node metastases. evaluating the functional contributions of cancer, found RAGE-deficient mice displayed reduced propensity for tumor growth. an established model lung metastasis, systemic blockade by injection neutralizing antibody inhibited...
S100A7/psoriasin, a member of the epidermal differentiation complex, is widely overexpressed in invasive estrogen receptor (ER)α-negative breast cancers. However, it has not been established whether S100A7 contributes to cancer growth or metastasis. Here, we report consequences its expression on inflammatory pathways that impact growth. Overexpression human murine homologue mS100a7a15 enhanced cell proliferation and upregulated various proinflammatory molecules ERα-negative cells. To examine...
Identification of predictive biomarkers is critically needed to improve selection patients who derive the most benefit from platinum-based chemotherapy. We hypothesized that decreased expression SMARCA4/BRG1, a known regulator transcription and DNA repair, novel biomarker increased sensitivity adjuvant therapies in non-small cell lung cancer (NSCLC).The prognostic value was tested using gene-expression microarray Director's Challenge Lung Study (n = 440). The significance SMARCA4 determined...
Abstract Introduction Although C-X-C motif chemokine 12 (CXCL12) has been shown to bind receptor type 7 (CXCR7), the exact molecular mechanism regulations by CXCL12/CXCR7 axis in breast tumor growth and metastasis are not well understood. CXCR7 expression be upregulated during pathological processes such as inflammation cancer. Methods Breast cancer cell lines were genetically silenced or pharmacologically inhibited for and/or its downstream target signal transducer activator of...
Abstract Tumor-associated macrophages (TAM) are heterogeneous in nature and comprise antitumor M1-like (M1-TAM) or pro-tumor M2-like (M2-TAM) TAMs. M2-TAMs a major component of stroma breast tumors enhance metastasis by reducing their phagocytic ability increasing tumor fibrosis. However, the molecular mechanisms that regulate phenotypic plasticity TAMs not well known. Here we report novel suppressor Slit2 cancer regulating microenvironment. reduced vivo growth spontaneous syngeneic mammary...
Abstract A unique phenotype of Waardenburg–Hirschsprung disease (WS4) accompanied by peripheral neuropathy and central dysmyelination has been recognized recently in association with SOX10 mutations. We report an infant boy lethal congenital hypomyelinating WS4 who had a heterozygous mutation (Q250X). Histopathological studies showed absence nerve myelin despite normal numbers Schwann cells profound the nervous system. These observations suggest that some mutations such as Q250X may allow...
Cannabinoids bind to cannabinoid receptors CB(1) and CB(2) have been reported possess anti-tumorigenic activity in various cancers. However, the mechanisms through which cannabinoids modulate tumor growth are not well known. In this study, we report that a synthetic non-psychoactive specifically binds receptor may breast metastasis by inhibiting signaling of chemokine CXCR4 its ligand CXCL12. This pathway has shown play an important role regulating cancer progression metastasis.We observed...
The purpose of this study was to investigate the radiogenomic correlation between CT gray-level texture features and epidermal growth factor receptor (EGFR) mutation status in adenocarcinoma lung.This retrospective included 25 patients with exon 19 short inframe deletion (exon 19) 21 L858R point 21) EGFR mutations among 125 mutant lung. randomly formed control group consisted 20 selected from 126 mutation-negative (wild-type) adenocarcinomas. Five (contrast, correlation, inverse difference...
Abstract EGFR tyrosine kinase inhibitors cause dramatic responses in EGFR-mutant lung cancer, but resistance universally develops. The involvement of β-catenin TKI has been previously reported, however, the precise mechanism by which activation contributes to is not clear. Here, we show that inhibition results signaling a Notch3-dependent manner, facilitates survival subset cells call “adaptive persisters”. We reported EGFR-TKI treatment rapidly activates Notch3, and here describe physical...
Thymic neuroendocrine tumors (TNET) are rare primary epithelial neoplasms of the thymus. This study aimed to determine clinically relevant parameters for their classification and therapeutic decisions. We performed a comprehensive histological, clinical, genetic 73 TNET cases (13 thymic typical carcinoids [TTC], 40 atypical [TAC], 20 high-grade carcinomas [HGNEC] thymus), contributed by multiple institutions. The mean number chromosomal imbalances per tumor was 0.8 in TTC (31% aberrant...
Transient receptor potential vanilloid type-2 (TRPV2) is an ion channel that triggered by agonists like cannabidiol (CBD). Triple negative breast cancer (TNBC) aggressive disease with limited therapeutic options. Chemotherapy still the first line for treatment of TNBC patients; however, usually gains rapid resistance and unresponsiveness to chemotherapeutic drugs. In this study, we found TRPV2 protein highly up-regulated in tissues compared normal tissues. We also observed estrogen alpha...
It is generally accepted that cellular, but not humoral immunity, plays an important role in host defense against intracellular bacteria. However, studies of some these pathogens have provided evidence antibodies can provide immunity if present during the initiation infection. Here, we examined infection by Ehrlichia chaffeensis, obligate bacterium causes human monocytic ehrlichiosis. Studies with mice demonstrated immunocompetent strains are resistant to persistent SCID become persistently...
// Janani Ravi 1 , Amita Sneh Konstantin Shilo Mohd W. Nasser and Ramesh K. Ganju Department of Pathology, The Ohio State University, Ohio, USA. Correspondence: Nasser, email: K Ganju, Keywords : NSCLC, EGFR, Met-F-AEA, FAAH Received December 19, 2013 Accepted February 2014 Published 21, Abstract endocannabinoid anandamide (AEA), a neurotransmitter was shown to have anti-cancer effects. Fatty acid amide hydrolase (FAAH) metabolizes AEA decreases its anti-tumorigenic activity. In this study,...
// Catherine A. Powell 1 , Mohd W. Nasser Helong Zhao Jacob C. Wochna Xiaoli Zhang 2 Charles Shapiro 3 Konstantin Shilo and Ramesh K. Ganju Department of Pathology, The Ohio State University, Columbus, OH, USA Center for Biostatistics, Tisch Cancer Institute, Mount Sinai School Medicine, New York, Correspondence to: Ganju, email: Keywords : Fatty acid binding protein 5, triple negative breast cancer, epidermal growth factor receptor, degradation, metastasis Received December 16, 2014...
IntroductionThymic epithelial tumors (TETs) including thymoma and thymic carcinoma are rare with little data available to guide treatment. Immunotherapy checkpoint blockade has shown promising activity, but regarding the expression patterns prognostic implications of programmed death 1 (PD-1) its ligand (PD-L1) in TETs have yielded conflicting results. Intratumoral heterogeneity PD-1/L1 been other cancers, not described TET literature.MethodsWe performed a retrospective single-center review...
BackgroundAn outbreak of E-cigarette or Vaping Product Use-Associated Lung Injury (EVALI) with significant morbidity and mortality was reported in 2019. While most patients EVALI report vaping tetrahydrocannabinol (THC) oils contaminated vitamin E acetate, a subset only nicotine-containing electronic cigarettes (e-cigs). Whether not e-cigs cause EVALI, the highlights need for identifying long term health effects e-cigs. pathology includes alveolar damage, pneumonitis and/or organizing...
To better characterize the clinical and pathologic features of granulomatous reaction to Pneumocystis jirovecii, we reviewed 20 cases this uncommon response. Patients included 15 males 5 females (mean age 52 y). The most common symptom was dyspnea (5 14). Primary medical diagnoses human immunodeficiency virus/acquired syndrome (7 20), hematopoietic (6 solid malignancies (4 20). Radiology findings nodular (8 16) diffuse infiltrates solitary nodules (3 16). Diagnostic procedures with highest...
Protein arginine methyltransferase-5 (PRMT5) is a chromatin-modifying enzyme capable of methylating histone and non-histone proteins, involved in wide range cellular processes that from transcriptional regulation to organelle biosynthesis. As such, its overexpression has been linked tumor suppressor gene silencing, enhanced cell growth survival. Quantitative real-time polymerase chain reaction, Western immunoblot immunohistochemistry were used characterize PRMT5 expression lung cancer lines...
Technologic advances have enabled the comprehensive analysis of genetic perturbations in non-small-cell lung cancer (NSCLC); however, African Americans often been underrepresented these studies. This ethnic group has higher incidence and mortality rates, some studies suggested a lower epidermal growth factor receptor mutations. Herein, we report most in-depth molecular profile NSCLC to date.A custom panel was designed cover coding regions 81 NSCLC-related genes 40 ancestry-informative...