A5087674995- Lymphoma Diagnosis and Treatment
- Viral-associated cancers and disorders
- Esophageal Cancer Research and Treatment
- Lung Cancer Treatments and Mutations
- Gastric Cancer Management and Outcomes
- Phagocytosis and Immune Regulation
- CNS Lymphoma Diagnosis and Treatment
- Myasthenia Gravis and Thymoma
- Cytokine Signaling Pathways and Interactions
- Organ and Tissue Transplantation Research
- Gas Sensing Nanomaterials and Sensors
- Esophageal and GI Pathology
- Sarcoma Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Lymphatic System and Diseases
- Salivary Gland Tumors Diagnosis and Treatment
- Head and Neck Cancer Studies
- Apelin-related biomedical research
- Ear and Head Tumors
- Advanced Chemical Sensor Technologies
- Analytical Chemistry and Sensors
- Cancer Mechanisms and Therapy
- Vascular Tumors and Angiosarcomas
- Cancer, Hypoxia, and Metabolism
- Immune Cell Function and Interaction
Chang Gung Memorial Hospital
2016-2025
Chang Gung University
2015-2024
Linkou Chang Gung Memorial Hospital
2013-2024
Tri-Service General Hospital
2023-2024
National Defense Medical Center
2023-2024
University of Würzburg
2005-2022
Clinical Research Consortium
2022
National Cheng Kung University Hospital
2022
National Taiwan University
2012-2019
Institute of Clinical Research
2019
Abstract Background Cyclin D1 gene regulates cell cycle and plays an important role in the tumorigenesis of human cancers. The association between cyclin D1, clinicopathologic parameters prognosis oral cavity squamous carcinoma (OSCC) is inconclusive. Methods A total 264 male OSCCs were examined for protein expression using immunohistochemistry (IHC). levels defined as overexpression when more than 10% tumor cells displayed nuclear staining with moderate to strong intensity. Results...
Thymic neuroendocrine tumors (TNET) are rare primary epithelial neoplasms of the thymus. This study aimed to determine clinically relevant parameters for their classification and therapeutic decisions. We performed a comprehensive histological, clinical, genetic 73 TNET cases (13 thymic typical carcinoids [TTC], 40 atypical [TAC], 20 high-grade carcinomas [HGNEC] thymus), contributed by multiple institutions. The mean number chromosomal imbalances per tumor was 0.8 in TTC (31% aberrant...
Detection of nodal micrometastasis (tumor size: 0.2-2.0 mm) is challenging for pathologists due to the small size metastatic foci. Since lymph nodes with are counted as positive nodes, detecting crucial accurate pathologic staging colorectal cancer. Previously, deep learning algorithms developed manually annotated images performed well in identifying breast cancer sentinel nodes. However, process manual annotation labor intensive and time consuming. Multiple instance was later used identify...
Recent studies have demonstrated a critical association between disruption of cellular thyroid hormone (TH) signaling and the incidence hepatocellular carcinoma (HCC), but underlying mechanisms remain largely elusive. Here, we showed that TH production results in marked increase progression diethylnitrosamine (DEN)-induced HCC murine model, conversely, administration suppresses carcinogenic process via activation autophagy. Inhibition autophagy treatment with chloroquine (CQ) or knockdown...
Pathologic diagnosis of nasopharyngeal carcinoma (NPC) can be challenging since most cases are nonkeratinizing with little differentiation and many admixed lymphocytes. Our aim was to evaluate the possibility identify NPC in biopsies using deep learning. A total 726 were included. Among them, 100 randomly selected as testing set, 20 validation all other 606 training set. All three datasets had equal numbers benign cases. Manual annotation performed. Cropped square image patches 256 × pixels...
Nonsmall cell lung cancer (NSCLC) is the most common type of cancer, which one prominent causes cancer-related mortality worldwide. Discovery serum tumor markers could facilitate early NSCLC detection and metastatic prognosis. Here, we simultaneously analyzed secretome proteomic profiles pleural effusion from adenocarcinoma patients for biomarker discovery. Retinoblastoma-associated binding protein 46 (RbAp46), proteins detected both in proteome, was chosen further evaluation. Both RbAp46...
Most primary intestinal natural killer (NK)-cell and T-cell lymphomas (PINKTL) in the Northern Europe are enteropathy-associated lymphomas, a complication of celiac disease, which is rare East. Primary NK-cell lymphoma extremely poorly characterized. We investigated 30 cases PINKTL from Taiwan with male: female at 2:1, median age 55.5, 80% jejunal/ileal involvement, 77% perforation, 27% multicentric tumors, 67% stage IE. All 7 tested for serum IgA anti-tissue transglutaminase were negative....
Abstract Background. To retrospectively compare the accuracies of ultrasound‐guided fine‐needle aspiration (USFNA) and core needle biopsy (USCNB) in diagnosis parotid masses. Methods. A total 171 patients (aged 17–86 years, mean 54 years) with masses (35 malignant 136 benign lesions) underwent either USFNA (n = 107) or USCNB 64). The diagnostic for differentiating from lesions both examinations were compared. Surgical histopathology 104) clinical 67) used to establish final diagnoses....
DNA repair systems are abnormally active in most hepatocellular carcinoma (HCC) cells due to accumulated mutations, resulting elevated capacity and resistance chemotherapy radiotherapy. Thus, targeting mechanisms is a common treatment approach HCC sensitize cancer damage. In this study, we examined the anti-HCC effects of melatonin elucidated regulatory mechanisms. The results functional assays showed that addition inhibiting proliferation, migration, invasion abilities cells, suppressed...
We previously reported that tumor inflammasomes play a key role in control and act as favorable prognostic markers nasopharyngeal carcinoma (NPC). Activated frequently form distinguishable specks govern the cellular secretion of IL-1β. However, we know little about biological biochemical differences between cells with without apoptosis-associated speck-like protein containing caspase-recruitment domain (ASC) speck formation. In this study, used proteomic iTRAQ analysis to analyze proteomes...
Background Plasma Epstein-Barr virus (EBV) DNA levels predict the prognosis of extranodal NK/T-cell lymphoma, nasal type (NK/TCL), but its role in other peripheral T-cell lymphomas (PTCL) remains undetermined. This study aimed to determine prognostic impact plasma EBV PTCL patients.
Abstract Myasthenia gravis (MG) in thymoma patients depends critically on intratumorous generation and export of mature autoreactive CD4 + T cells. Why non‐MG thymomas fail to produce cells is unknown. We studied three single‐nucleotide polymorphisms the cytotoxic T‐lymphocyte–associated antigen 4( CTLA4 ) gene patients, nonthymoma early‐onset MG control subjects. Surprisingly, high genotype +49A/A, which protective against several autoimmune diseases, exerted a prominent predisposing effect...
Podoplanin is a mucin-like glycoprotein expressed in the lymphatic endothelium. It has been suggested to play role lymphangiogenesis, since podoplanin deficient mice were found have dilated malfunctioning vessels and lymphedema. High expression tumor cells was correlate with lymph node metastasis poor clinical outcome patients oral squamous cell carcinoma (SCC). However, prognostic significance of esophageal SCC remains unexplored. Herein, we studied 59 who underwent surgical resection SCC,...
Generation of autoreactive CD4 + effector T cells and defective production regulatory inside thymomas contribute to the development myasthenia gravis (MG) in >90% MG(+) thymomas. The molecular basis these abnormalities is unknown. We report here that a) expression levels class II major histocompatibility complex (MHCII) genes are variably decreased thymomas, most prominently histological WHO types A AB; b) epithelial type AB exhibit signal transducer activator transcription...
Background & Aims: Hepatocellular carcinoma (HCC) is among the leading causes of cancer deaths worldwide. Many studies indicate that disruption cellular thyroid hormone signaling promotes HCC progression. However, mechanisms underlying regulation genes downstream actions in have remained elusive. In current study, we identified NUPR1 (nuclear protein-1), a stress-induced protein overexpresses various neoplasia, upregulated by triiodothyronine/thyroid receptor (T3/TR) and aimed to elucidate...
The purpose of this work was to evaluate the performance an existing commercially available artificial intelligence (AI) software system in differentiating malignant and benign lung nodules. AI tool consisted a vessel-suppression function deep-learning-based computer-aided-detection (VS-CAD) analyzer. Fifty patients (32 females, mean age 52 years) with 75 nodules (47 28 benign) underwent low-dose computed tomography (LDCT) followed by surgical excision pathological analysis their within 3...
Benign lesions, atypical adenomatous hyperplasia (AAH), and malignancies such as adenocarcinoma in situ (AIS), minimally invasive (MIA), (IA) may feature a pure ground-glass nodule (pGGN) on thin-slide computed tomography (CT) image. According to the World Health Organization (WHO) classification for lung cancer, prognosis of patients with IA is worse than those AIS MIA. It relatively risky perform core needle biopsy pGGN less 2 cm obtain reliable pathological diagnosis. The early adequate...