A5087356851- T-cell and Retrovirus Studies
- Lymphoma Diagnosis and Treatment
- Viral-associated cancers and disorders
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Cancer-related gene regulation
- Immune Cell Function and Interaction
- Head and Neck Cancer Studies
- Histiocytic Disorders and Treatments
- Cancer Immunotherapy and Biomarkers
- RNA modifications and cancer
- Eosinophilic Disorders and Syndromes
- Epigenetics and DNA Methylation
- Mast cells and histamine
- Oral and Maxillofacial Pathology
- Cutaneous lymphoproliferative disorders research
- CNS Lymphoma Diagnosis and Treatment
- Chronic Disease Management Strategies
- Vascular Tumors and Angiosarcomas
- Lung Cancer Treatments and Mutations
- Acute Lymphoblastic Leukemia research
- Cancer Genomics and Diagnostics
- Parvovirus B19 Infection Studies
- Bone and Dental Protein Studies
Sun Yat-sen University
2015-2024
Sun Yat-sen University Cancer Center
2015-2024
University of Colorado Denver
2021
University of Colorado Cancer Center
2021
State Key Laboratory of Oncology in South China
2009-2020
National Institute of Diabetes and Digestive and Kidney Diseases
2019
ProQuest (United States)
2019
Bioengineering Center
2019
National Cancer Center
2010
Doncaster Royal Infirmary
2008
Pulmonary lymphoepithelioma-like carcinoma (LELC) is a rare kind of cancer.In this study, the authors evaluated 52 patients with pulmonary LELC who had long-term follow-up. Clinical characteristics, tumor markers, epidermal growth factor receptor (EGFR) mutation status, treatments, and outcomes were analyzed.Pulmonary mostly affected young, nonsmoking patients. Most in early or locally advanced stages received multimodality treatment. Serum levels neuron-specific enolase cytokeratin 19...
Pulmonary sarcomatoid carcinoma (PSC) is a rare malignancy.A total of 69 patients with PSC treated at single institution in southern China long-term follow-up were evaluated this study. We analyzed the clinical characteristics, immunohistochemical profiles, epidermal growth factor receptor mutation status, K-RAS treatments, and prognosis.PSC mainly occurred young male history smoking. Most received multimodality treatments majority had early-stage disease. The median survival time was 19.1...
BACKGROUND The utility of circulating Epstein‐Barr Virus (EBV) DNA as a tumor marker for nasopharyngeal carcinoma (NPC) detection suggests that it might improve the diagnostic performance anti‐EBV antibody markers in NPC screening. In this study, authors evaluated whether EBV load is capable distinguishing patients from high‐risk individuals who have positive antibodies. METHODS population‐based screening trial Sihui City and Zhongshan City, Guangdong Province, China, previously identified...
Castleman disease ( CD ) is a rare lymphoproliferative disorder. To assess the clinical features, outcomes, and prognostic factors of this disease, we retrospectively analyzed 185 HIV ‐negative patients from four medical centers in southern China. The median age was 37 years. One hundred twenty‐one (65.4%) were classified as unicentric UCD 64 (34.6%) multicentric MCD ). histology subtype hyaline‐vascular for 132 (71.4%), plasma cell 50 (27%), mixed type 3 (1.6%). 5‐year overall survival OS...
Human interacting protein X1 (PinX1) has been identified as a critical telomerase inhibitor and proposed to be putative tumor suppressor gene. Loss of PinX1 found in large variety malignancies, but the expression status epithelial ovarian tumors not investigated. In this study, immunohistochemistry for was performed on tissue microarray (TMA) (informatively containing 25 cystadenomas, 29 borderline tumors, 157 invasive carcinomas) 12 normal ovaries. Receiver-operator curve (ROC) analysis...
Abstract Purpose: Deregulation of microRNA (miRNA) has been extensively investigated in both Hodgkin and non-Hodgkin lymphomas (NHL); however, little is known about the roles miRNAs T-cell lymphoblastic lymphoma (T-LBL). The aim present study was to investigate potential miR-374b development treatment T-LBL. Experimental Design: MiRCURY LNA array used generate a miRNA-expressing profile. Real-time quantitative PCR immunohistochemistry (IHC) were applied detect expression miR-374b, AKT1,...
The programmed cell death-1 (PD-1)/programmed death-ligand 1 (PD-L1) pathway inhibits the activation of T cells and plays a crucial role in negative regulation cellular humoral immune responses. Diffuse large B-cell lymphoma (DLBCL) is most common lymphoid malignancy adults. In present study, we aimed to detect expression PD-L1 DLBCL analyze its relationship with prognosis.We reviewed medical records 204 newly diagnosed patients Sun Yat-sen University Cancer Center between October 2005...
PURPOSE Screening for nasopharyngeal carcinoma (NPC) has shown an improvement in early detection and survival rates of NPC endemic regions. It is critical to evaluate whether screening can reduce NPC-specific mortality the population. METHODS Sixteen towns Sihui Zhongshan cities, China, were selected; eight randomly allocated group control group. Residents age 30-69 years with no history included from January 1, 2008, December 31, 2015. invited undergo serum Epstein-Barr virus (EBV) viral...
Background Lymphoepithelioma-like carcinoma (LELC) in the salivary glands is a rare but unique malignancy. Methods Sixty-nine patients with gland LELC long-term follow-up were reviewed for this study. Results There 52 cases parotid and 17 submandibular gland. All underwent complete tumor excision, 41 neck dissection, 39 received postoperative radiotherapy. The 5-year, 10-year, 15-year overall survival (OS) rates 90%, 75%, 54%, respectively. Patients higher neutrophil/lymphocyte ratio (NLR ≥...
Circulating tumor DNA (ctDNA) carries tumor-specific genetic and epigenetic variations. To identify extranodal natural killer/T cell lymphoma (ENKTL)-specific methylation markers establish a diagnostic prognosis prediction model for ENKTL, we describe the ENKTL-specific ctDNA patterns by analyzing profiles of ENKTL plasma samples. We construct based on with both high specificity sensitivity close relevance to staging therapeutic response. Subsequently, built prognostic showing excellent...
Mature T-cell and natural killer (NK)-cell lymphomas compose a heterogeneous group of non-Hodgkin lymphomas, extranodal NK/T-cell lymphoma, nasal type (ENKTL) is an aggressive subtype with sporadic CD30 expression. However, the significance expression in ENKTL controversial. We aimed to classify large cohort patients mature NK-cell according 2016 World Health Organization (WHO) classification guidelines study association between prognosis ENKTL.We selected consecutive who attended our...
Hydroa vacciniforme-like lymphoproliferative disorder (HV-LPD) is a cutaneous form of chronic active Epstein-Barr virus (EBV) infection, which occurs mainly in children Latin America and Asia. It can progress to systemic lymphoma. However, prognostic factors treatment remain unclear.This retrospective study reviewed the clinical, morphologic, immunophenotypical features, clinical 19 patients with HV-LPD.All had skin lesions face, extremities, or areas unexposed sun, including edema,...
AIB1 (amplified in breast cancer 1) is frequently overexpressed esophageal squamous cell carcinoma (ESCC), but the significance of expression chemoradiotherapy (CRT) sensitivity and its effect on prognosis are still unclear. In this study, was examined by immunohistochemistry 98 biopsy specimens primary ESCC patients treated with definitive CRT. overexpression found 63/98 (64.3%) ESCCs. There a significant association between distant lymph node metastases ( P = 0.011), not regional...
The authors investigated the status of abnormalities eIF‐5A2 gene in superficial (pTa/pT1) urothelial carcinoma bladder (UC), as well its correlation with clinicopathologic variables and patient outcome. methods immunohistochemistry (IHC), fluorescence situ hybridization (FISH), reverse transcription‐polymerase chain reaction (RT‐PCR) Wetern blotting were utilized to examine protein/mRNA(messenger RNA) expression amplification a cohort pTa/pT1 UCs. Overexpression EIF‐5A2 was examined by IHC...
Abstract Background The 8th American Joint Committee on Cancer tumor–node–metastasis (AJCC‐TNM) staging system is based a few retrospective single‐center studies. We aimed to test the prognostic validity of and determine whether modified clinicopathological tumor that includes lymphovascular embolization could increase accuracy prediction for patients with stage T2–3 penile cancer. Methods A training cohort 411 who were treated at 2 centers in China Brazil between 2000 2015 staged according...
Abstract Background Adult patients with T‐cell lymphoblastic lymphoma (T‐LBL) are treated high‐intensity chemotherapy regimens, but the response rate is still unsatisfactory because of frequent drug resistance. We aimed to investigate potential mechanisms resistance in adults T‐LBL. Methods Gene expression microarray was used identify differential mRNA profiles between chemotherapy‐resistant and chemotherapy‐sensitive adult T‐LBL tissues. Real‐time PCR immunohistochemistry were performed...
Abstract Deletion of 19p13 is one the most frequent genetic changes in gastric carcinoma (GC), implying existence a tumor suppressor gene (TSG) that plays an important role GC development. To identify candidate TSG at 19p, array‐comparative genomic hybridization (CGH) was applied to study DNA copy‐number on chromosomes 3, 5p, 13, 16q and 19. The result showed gains 16q21, 19q13.1, 5p15.1 3q26.31, losses 3p21.32, 3p22.2, 19q13.33 19p13.3, were frequently detected by array‐CGH. One TSG, ZIP...