A5008709858- Genital Health and Disease
- Urological Disorders and Treatments
- Urologic and reproductive health conditions
- Social and Educational Sciences
- Cervical Cancer and HPV Research
- Research in Social Sciences
- Renal cell carcinoma treatment
- Female Genital Mutilation/Cutting Issues
- Advanced Proteomics Techniques and Applications
- Bladder and Urothelial Cancer Treatments
- Textile materials and evaluations
- Mechanical and Thermal Properties Analysis
- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Ethics and Legal Issues in Pediatric Healthcare
- Renal and related cancers
- Ureteral procedures and complications
- Colorectal and Anal Carcinomas
- Urinary and Genital Oncology Studies
- Orthopedic Surgery and Rehabilitation
- Sexual function and dysfunction studies
- Ergonomics and Musculoskeletal Disorders
- Genetic factors in colorectal cancer
- Cutaneous Melanoma Detection and Management
- Ferroptosis and cancer prognosis
Hospital Estadual Mário Covas
2009-2025
Instituto Nacional do Câncer
2012-2024
Universidade do Estado do Rio de Janeiro
2017-2023
Hospital Municipal Souza Aguiar
2013-2021
University of Tampa
2020
National Cancer Institute
2013
Hospital do Câncer III
2010
Hospital Central da Polícia Militar
2009
Hospital Israelita Albert Einstein
2007
Between 1960 and 1987, 414 patients with invasive squamous cell carcinoma of the penis were referred to Brazilian National Cancer Institute. Inguinal metastases demonstrated by lymphadenectomy in 39% 23 stage N0, 49% 92 stages N1 N2, 100% 18 N3 disease. We analyzed followup 350 who underwent surgical treatment. In 224 (64%) amputation or some form penile surgery was done initially, while 102 (29%) lymphadenectomy, 24 (7%) palliative for advanced carcinoma. The statistics revealed a better...
Abstract Background and Objectives We reviewed our long‐term experience with surgical treatment of patients penile carcinoma. Methods From 1960 to 2006, 688 carcinoma underwent at Institute. Several forms were compared follow‐up data analyzed. Results Stage stratification demonstrated a better survival rate for stages T1N0 T1N1,T2N0‐1. Patients well differentiated had higher than those moderately poorly ( P < 0.0001 = 0.006). Risk showed in the low‐risk group (T1G1,T1G2) 0.013 0.00001)....
We reviewed our recent experience with inguinal lymph node dissection in patients penile cancer to assess the incidence and magnitude of complications caused by this procedure.Radical bilateral lymphadenectomy was performed 170 (340 procedures). Prophylactic therapeutic radical done 67 (39.4%) 103 (60.6%), respectively. Operative time length hospital stay were examined. Complications divided into minor major, early (30 days or less after surgery) late (greater than 30 days), analyzed.A total...
No AccessJournal of UrologyAdult urology1 Mar 2007Video Endoscopic Inguinal Lymphadenectomy: A New Minimally Invasive Procedure for Radical Management Nodes in Patients With Penile Squamous Cell Carcinoma Marcos Tobias-Machado, Alessandro Tavares, Antônio Augusto Ornellas, Wilson Rica Molina, Roberto Vaz Juliano, and Eric Roger Wroclawski Tobias-MachadoMarcos Tobias-Machado More articles by this author , TavaresAlessandro Tavares OrnellasAntônio Ornellas MolinaWilson Molina JulianoRoberto...
From 1972 to 1987, 200 consecutive lymphadenectomies were performed in 112 patients with squamous cell carcinoma of the penis. A Gibson incision provided exposure iliac and inguinal lymph nodes a low morbidity rate (5% flap necrosis, 15% wound infection, 16% lymphedema 9% lymphocele). The controversy surrounding necessity lymphadenectomy is discussed, since 305 examined did not have metastatic invasion.
No AccessJournal of UrologyAdult Urology1 Oct 2008Prognostic Factors in Invasive Squamous Cell Carcinoma the Penis: Analysis 196 Patients Treated at Brazilian National Cancer Institute Antonio Augusto Ornellas, Bernardo Lindenberg Braga Nóbrega, Eduardo Wei Kin Chin, Aristóteles Wisnescky, Paulo Cesar Barbosa da Silva, and Aline Barros de Santos Schwindt OrnellasAntonio Ornellas , NóbregaBernardo Nóbrega ChinEduardo Chin WisnesckyAristóteles Wisnescky SilvaPaulo Silva SchwindtAline View All...
To determine epidemiological characteristics of penile cancer in Rio de Janeiro, its associated risk factors and clinical manifestations.Between 2002 2008 we evaluated 230 patients at three public institutions, considering age, ethnicity, birthplace, marital status, educational level, religion, tobacco smoking, presence phimosis practice circumcision.The ages ranged from 25 to 98 years, with an average 58.35 years. Of the patients, 167 (72.7%) were southeast region Brazil (which includes...
Inguinal lymph node dissection plays an important role in the management of melanoma, penile and vulval cancer. is associated with various intraoperative postoperative complications significant heterogeneity classification reporting. This lack standardization challenges efforts to study report inguinal outcomes. The aim this was devise a system standardize reporting perioperative by creating worldwide collaborative, adverse events lymphadenectomy area (CALI) group.
Recently, we were able to show that satellite DNA amplification (satDNA-AMP) is present in advanced prostate cancer. A chromosome microarray study provided first evidence satDNA-AMP appears be largely independent of centromere-near/pericentric euchromatic copy number alterations. Therefore, it might carefully suggested could a new and marker for tumor progression:
In various solid tumors and corresponding cell lines, prior research has identified acquired copy number variations (CNVs) encompassing centromeric satellite-DNA sequences. This observation emerged from the application of probes (satellite-DNA) as controls in molecular cytogenetic investigations diagnostics, although these accounts were largely anecdotal. this study, we conducted a systematic screening for sequence amplification 31 prostate cancer (PCa) samples, prevalent malignancy men...
OBJECTIVE: To determine the prevalence of human papillomavirus (HPV) DNA in penile cancers Rio de Janeiro, Brazil. MATERIALS AND METHODS: We studied, prospectively, 80 consecutive cases patients with who underwent surgical treatment at three different Hospitals Janeiro between March 1995 and June 2000. Of these patients, 72 were diagnosed invasive squamous cell carcinoma 8 verrucous carcinoma. The following parameters observed: presence or absence HPV viral type, histological subtypes,...
To describe our experience in treating penile melanoma 06 patients followed at institution.Between 2004 and 2012 six consecutive with were treated Institution. Stage of the disease was classified according to 2002 AJCC pathologic system. Melanoma situ (TIS) diagnosed one patient. One patient staged as T1b, two T2b T4b. The clinical pathological findings evaluated. Immunohistochemical tests performed for Melan-A, HNB-45, S-100 C-KIT. All histological specimens examined by same pathologist...
No AccessJournal of UrologyAdult Urology1 Jun 2016High Risk Human Papillomavirus Infection the Foreskin in Asymptomatic Men and Patients with Phimosis Larissa A. Afonso, Thaissa I. Cordeiro, Fernanda N. Carestiato, Antonio Augusto Ornellas, Gilda Alves, Sílvia M.B. Cavalcanti AfonsoLarissa Afonso Department Microbiology Parasitology, Instituto Biomédico, Universidade Federal Fluminense, Niterói, Brazil , CordeiroThaissa Cordeiro CarestiatoFernanda Carestiato OrnellasAntonio Ornellas Urology,...
To report outcomes from the largest multicenter series of penile cancer patients undergoing video endoscopic inguinal lymphadenectomy (VEIL).Retrospective analysis. Authors 21 centers Penile Cancer Collaborative Coalition-Latin America (PeC-LA) were included. All performed procedure following same previously described standardized technique. Inclusion criteria included with no palpable lymph nodes and intermediate/high-risk disease those non-fixed less than 4 cm in diameter. Categorical...
Between 1972 and 1987, 34 patients with verrucous carcinoma of the penis were referred to our national cancer institute. We analyzed retrospectively followup 32 treated by surgery, exclusive radiotherapy neoadjuvant chemotherapy. No patient died or had recurrent penile carcinoma. Lymph nodes removed from 15 without previous treatment did not reveal metastatic invasion. Neoadjuvant chemotherapy allowed for more limited surgery in 3 6 treated.
Penile cancer is a potentially mutilating disease. Although its occurrence relatively rare worldwide, penile rates can be high in developing countries. A few studies have been conducted on the involvement of human papillomavirus (HPV) carcinoma, which found HPV present 30-70% malignant lesions, with higher prevalence 16 and 18. It has assumed that cofactors, such as Epstein-Barr virus (EBV) infections, may play role progression neoplasia. The aim this study was to determine EBV 135 lesions...
Abstract Background The 8th American Joint Committee on Cancer tumor–node–metastasis (AJCC‐TNM) staging system is based a few retrospective single‐center studies. We aimed to test the prognostic validity of and determine whether modified clinicopathological tumor that includes lymphovascular embolization could increase accuracy prediction for patients with stage T2–3 penile cancer. Methods A training cohort 411 who were treated at 2 centers in China Brazil between 2000 2015 staged according...
Purpose: To study the effect of penile constriction devices used on a large series patients who presented at our emergency facility. We explored treatment options to prevent wide range vascular and mechanical injuries occurring due entrapment. Materials Methods: Between January 2001 March 2016, 26 with entrapment were admitted facility prospectively evaluated. Results: The time that elapsed from constrictor application hospital admission varied 10 hours 6 weeks (mean: 22.8 hours)....
Objective To evaluate the prognostic impact of lymph node yield ( LNY ) on survival outcomes for penile squamous cell carcinoma (SCC). Patients and methods In all, 532 patients who underwent inguinal LN dissection ILND across tertiary referral centres from Europe, China, Brazil North America were retrospectively evaluated. From this cohort, 198 received pelvic LND PLND ).We identified threshold values using receiver operating characteristic curves. We tested value recurrence‐free RFS ),...
Abstract To obtain more information on chromosomal changes in the up‐to‐now poorly studied tumor class of penile squamous cell carcinoma (SCC), we performed a comparative genomic hybridization study 26 cases this rare tumor. DNA sequence copy number alterations (CNAs) very similar to those detected other SCC types, such as oral and esophageal SCC, were noted. The most common gains found 8q24, 16p11–12, 20q11–13, 22q, 19q13, 5p15, deletions 13q21–22, 4q21–32, along X chromosome. Classifying...