A5100457912- Renal cell carcinoma treatment
- Bladder and Urothelial Cancer Treatments
- Inflammatory Biomarkers in Disease Prognosis
- Prostate Cancer Treatment and Research
- Urologic and reproductive health conditions
- Prostate Cancer Diagnosis and Treatment
- Esophageal Cancer Research and Treatment
- Urological Disorders and Treatments
- Cancer Immunotherapy and Biomarkers
- Urinary Bladder and Prostate Research
- Renal and related cancers
- Urinary and Genital Oncology Studies
- Adrenal and Paraganglionic Tumors
- Genital Health and Disease
- Cancer Genomics and Diagnostics
- Pituitary Gland Disorders and Treatments
- Lung Cancer Diagnosis and Treatment
- Urinary Tract Infections Management
- Esophageal and GI Pathology
- Helicobacter pylori-related gastroenterology studies
- Multiple and Secondary Primary Cancers
- Acute Kidney Injury Research
- Nutrition and Health in Aging
- Sarcoma Diagnosis and Treatment
- Hormonal Regulation and Hypertension
Second People's Hospital of Yunnan Province
2024
West China Medical Center of Sichuan University
2019-2024
First Affiliated Hospital of Xi'an Jiaotong University
2014-2024
Washington University in St. Louis
2024
Second Affiliated Hospital of Zhejiang University
2024
First People's Hospital of Chongqing
2019-2024
Sichuan University
2014-2023
West China Hospital of Sichuan University
2013-2023
Fuwai Yunnan Cardiovascular Hospital
2023
Kunming Children's Hospital
2023
Background The prognosis of patients with unresectable or metastatic biliary tract cancer (BTC) is unacceptably low. This study aimed to determine the efficacy, safety and predictive biomarkers immune checkpoint inhibitor nivolumab in combination chemotherapy advanced BTCs. Methods In this open-label, single-arm, phase II trial, a immunotherapy consisting gemcitabine 1000 mg/m 2 , cisplatin 75 3 mg/kg was administered every weeks for up six cycles. Maintenance treatment plus achieving...
This phase II study (NCT03469557) assessed safety/tolerability and antitumor activity of first-line tislelizumab, a monoclonal antibody against programmed cell death-1, plus chemotherapy in patients with locally advanced/metastatic esophageal squamous carcinoma (ESCC) or gastric/gastroesophageal junction (G/GEJ) adenocarcinoma.Patients ESCC received tislelizumab [200 mg i.v. every 3 weeks (Q3W)] cisplatin (80 mg/m² Q3W for ≤6 cycles) fluorouracil (800 mg/m²/day i.v., Days 1-5 cycles); G/GEJ...
Abstract TFE3 -translocation renal cell carcinoma ( -tRCC) is a rare and heterogeneous subtype of kidney cancer with no standard treatment for advanced disease. We describe comprehensive molecular characteristics 63 untreated primary -tRCCs based on whole-exome RNA sequencing. -tRCC highly heterogeneous, both clinicopathologically genotypically. ASPSCR1-TFE3 fusion several somatic copy number alterations, including the loss 22q, are associated aggressive features poor outcomes. Apart from...
Background Intraductal carcinoma of prostate (IDC-P) is always underestimated pathological pattern in cancer and its role still unclear castration resistant (CRPC). This study was conducted to investigate the presence roles IDC-P patients with metastatic CRPC. Methods 45 initially diagnosed then progressed CRPC, were included. All them received twice transperineal biopsies at time initial diagnosis samples retrieved detect IDC-P. PSA doubling (PSADT) considered as a parameter presenting...
A novel systemic immune-inflammation index (SII), based on the neutrophils, lymphocytes and platelet counts, is associated with prognosis of several cancers. The present study evaluates prognostic significance SII in non-metastatic renal cell carcinoma (RCC).The retrospectively reviewed medical record patients RCC who underwent nephrectomy between 2010 2013. Receiver operating characteristic (ROC) curve analysis was performed to identify optimal cut-off value. In addition, propensity score...
Manganese (Mn), cadmium (Cd) and lead (Pb) have toxic effects on the immune system. However, their independent combined immune-inflammation responses are unclear. In recent years, systemic index (SII) has been developed as an integrated novel inflammatory indicator. A retrospective cross-sectional study of 2174 adults ≥20 years old from National Health Nutrition Examination Survey (NHANES) 2015-2016 was conducted. Generalized linear models were used to evaluate associations SII with blood...
The association between insulin resistance and urinary incontinence (UI) has not been investigated widely. purpose of this study is to assess the relationship a novel indicator for assessing metabolic score (METS-IR) index (UI).This utilized data from National Health Nutrition Examination Survey (NHANES) 2001-2018. Weighted multivariable logistic regression models were conducted explore METS-IR with three types UI [stress (SUI), urgency (UUI), mixed (MUI)]. Smooth curve fitting was...
Colorectal cancer (CRC) metastasis is highly aggressive and associated with poor outcomes. Recent studies have highlighted greater heterogeneity in gene expression within metastatic tumor cells compared to primary cells. However, the underlying factors driving these differences remain poorly understood. We hypothesize that both genetic alterations microenvironment play key roles shaping this heterogeneity. To investigate aspects, we established a cohort through Human Tumor Atlas Network...
// Jinge Zhao 1, * , Pengfei Shen Guangxi Sun Ni Chen 2, Jiandong Liu 1 Xin Tang 3 Rui Huang 4 Diming Cai 5 Jing Gong 2 Xingming Zhang Zhibin Xiang Li Qiang Wei Peng Zhenhua Jiyan and Hao Zeng Department of Urology, Institute West China Hospital, Sichuan University, Chengdu, 610041, Pathology, Oncology, Nuclear Medicine, Ultrasound, These authors contributed equally to this work Correspondence to: Zeng, email: cdhx510@foxmail.com Liu, kucaizeng@163.com Keywords: metastatic...
Multiple myeloma (MM) remains incurable primarily due to relapse. Histone deacetylase inhibitors (HDACis) have shown potential application for the treatment of relapsed/refractory multiple (RRMM). To assess efficacy and safety HDACis in RRMM treatment, a systematic review meta‑analysis were conducted based on clinical trial data. A literature search was performed using PubMed, EMBASE, Web Science Cochrane Library databases. Subsequently, 19 trials with 2193 patients treated one three HDACis,...