A5067425796- Renal cell carcinoma treatment
- Epigenetics and DNA Methylation
- Prostate Cancer Treatment and Research
- Phagocytosis and Immune Regulation
- Renal and related cancers
- Prostate Cancer Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Glioma Diagnosis and Treatment
- Urologic and reproductive health conditions
- Bone and Dental Protein Studies
- Pancreatic and Hepatic Oncology Research
- Cancer Immunotherapy and Biomarkers
- Neuroendocrine Tumor Research Advances
- Ferroptosis and cancer prognosis
- Medical Imaging and Pathology Studies
- Neuroblastoma Research and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Cancer, Hypoxia, and Metabolism
- dental development and anomalies
- Cancer-related molecular mechanisms research
- Histone Deacetylase Inhibitors Research
- Prenatal Substance Exposure Effects
- Dental Trauma and Treatments
- Dental Health and Care Utilization
- Aldose Reductase and Taurine
Sichuan University
2018-2025
West China Hospital of Sichuan University
2019-2025
State Key Laboratory of Oral Diseases
2018-2023
State Key Laboratory of Biotherapy
2020-2022
West China Medical Center of Sichuan University
2022
Abstract TFE3 -translocation renal cell carcinoma ( -tRCC) is a rare and heterogeneous subtype of kidney cancer with no standard treatment for advanced disease. We describe comprehensive molecular characteristics 63 untreated primary -tRCCs based on whole-exome RNA sequencing. -tRCC highly heterogeneous, both clinicopathologically genotypically. ASPSCR1-TFE3 fusion several somatic copy number alterations, including the loss 22q, are associated aggressive features poor outcomes. Apart from...
Abstract Purpose: Fumarate hydratase–deficient renal cell carcinoma (FH-deficient RCC) is a rare but lethal subtype of RCC. Little known about the genomic profile FH-deficient RCC, and therapeutic options for advanced disease are limited. To this end, we performed comprehensive genomics study to characterize epigenomic features Experimental Design: Integrated genomic, epigenomic, molecular analyses were on 25 untreated primary RCCs. Complete clinicopathologic follow-up data these patients...
Diffuse midline glioma, H3 K27M-mutant (H3 K27M-mt DMG), is a rare and highly aggressive tumor that more common in children than adults. Few studies have compared the differences between pediatric adult patients with this tumor. We here report our retrospective study of 94 70 cases diffuse glioma. Surgical samples were analyzed by routine histopathology immunohistochemistry for K27M, IDH1 R132H, ATRX, p53, OLIG2, glial fibrillary acidic protein, Ki-67; Sanger sequencing hot mutation spots...
Fumarate hydratase-deficient renal cell carcinoma (FH-RCC) is a rare highly aggressive subtype of kidney cancer for which the distinct genomic, transcriptomic, and evolutionary relationships between metastatic primary lesions are still unclear.
Abstract Intraductal carcinoma of the prostate (IDC-P) is a lethal cancer subtype that generally coexists with invasive high-grade acinar adenocarcinoma (PAC) but exhibits distinct biological features compared concomitant adenocarcinoma. In this study, we performed whole-exome, RNA, and DNA-methylation sequencing IDC-P, concurrent PAC lesions, adjacent normal tissues isolated from 22 radical prostatectomy specimens. Three evolutionary patterns IDC-P were identified: early divergent, late...
Aims Xp11 translocation renal cell carcinoma (RCC) is a distinctive subtype of RCC with TFE3 (Transcription Factor Binding to IGHM Enhancer 3) gene rearrangement. The gross features in most RCCs closely resemble clear RCCs. In this study, we report six cases unique multicystic architecture, reminiscent multilocular cystic neoplasm low malignant potential (MCRN-LMP). Methods and results Microscopically, the mass was well circumscribed architecture. cyst walls septa were mostly lined by single...
Abstract Purpose: Fumarate hydratase–deficient renal cell carcinoma (FH-deficient RCC) is a rare and lethal subtype of kidney cancer. However, the optimal treatments molecular correlates benefits for FH-deficient RCC are currently lacking. Experimental Design: A total 91 patients with from 15 medical centers between 2009 2022 were enrolled in this study. Genomic bulk RNA-sequencing (RNA-seq) performed on 88 45 untreated RCCs, respectively. Single-cell RNA-seq was to identify biomarkers...
Abstract Leiomyoma is the most prevalent benign tumor of female reproductive system. Benign metastasizing leiomyoma (BML) a rare phenomenon that presents at distant sites, typically lungs, exhibiting histopathological features similar to primary uterine in absence malignancy both. Fumarate hydratase-deficient (FH-d UL) an uncommon subtype among smooth muscle tumors (0.5–2%), showing distinctive histomorphology and FH inactivation. The majority FH-d ULs are sporadic, caused by somatic...
Glioma is the most common intracranial malignant tumor, with poor prognosis. The new World Health Organization (WHO) integrated classification (2016) for diffuse glioma mainly based on status of isocitrate dehydrogenase (IDH) gene ( IDH ) mutation and 1p/19q codeletion, separated into three distinct molecular categories: chromosome codeletion/ mutant, intact / wild‐type. Gliomas harboring codeletion but without are rare cannot be classified according to revision WHO classification. Here we...
Dental caries is one of the most important chronic oral diseases that seriously threaten human health. Because characteristics high incidence, low rate treatment and retreatment, conventional prevention strategies cannot effectively control occurrence caries. This article proposes concept whole life cycle management dental caries, focusing on group according to different ages physiological hand, personal various risk factors levels individual patient other achieve goals controlling multiple...
A 69-year-old man presented with a submucosal tumor in the anterior wall of lower body stomach ([Fig. 1]). He reported no obvious discomfort. His medical history was significant for hypertension, which controlled by oral administration amlodipine. Physical examination detected abnormalities. Endoscopic ultrasound showed solid cystic lesion, had clear boundary and originated from muscularis mucosae 2]). Enhanced computed tomography confirmed presence low-density lesion 3]). At patient's...
Abstract TFE3 -translocation renal cell carcinoma ( -tRCC) is a rare and heterogeneous subtype of kidney cancer that has no standard treatment for advanced disease. We described comprehensive molecular characteristics 63 untreated primary -tRCCs based on whole-exome RNA sequencing. -tRCC highly heterogeneous, both clinicopathologically genotypically. ASPSCR1-TFE3 fusion, certain fusion isoforms high somatic copy number alteration burdens were associated with aggressive features poor...
CDK12 (Cyclin-Dependent Kinase 12)-mutated prostate cancer patients often respond badly to current therapies. Immunotherapy and platinum-based chemotherapy are recommended based on the molecular features of CDK12-mutated tumors, but reported patient outcomes still unsatisfying. Here we report a with somatic mutation who received multiple therapy options, including immunotherapy. His sequential circulating tumor DNA (ctDNA) -based liquid biopsy tests showed that his original fell undetectable...
Metanephric adenomas (MAs) are rare, benign renal tumors. Wilms' tumors (WTs) malignant embryonic that originated from nephrogenic blastemal cells. However, some have similar morphology to both MA and epithelial-predominant WT, which makes differential diagnosis difficult. We aimed analyze the morphological, immunophenotypic molecular changes in overlapping cases explore their attribution. Twenty MAs, ten WTs, nine with MA/WT histological features were studied. demonstrated typical...
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<p>Supplementary Methods</p>
<p>Table S4</p>