Xingming Zhang

ORCID: 0000-0002-0369-1201
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About
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Research Areas
  • Renal cell carcinoma treatment
  • Epigenetics and DNA Methylation
  • Phagocytosis and Immune Regulation
  • Prostate Cancer Treatment and Research
  • Prostate Cancer Diagnosis and Treatment
  • Urologic and reproductive health conditions
  • Cancer Immunotherapy and Biomarkers
  • Cancer-related molecular mechanisms research
  • PARP inhibition in cancer therapy
  • Ferroptosis and cancer prognosis
  • Bladder and Urothelial Cancer Treatments

Sichuan University
2022-2024

West China Hospital of Sichuan University
2022-2024

Abstract Intraductal carcinoma of the prostate (IDC-P) is a lethal cancer subtype that generally coexists with invasive high-grade acinar adenocarcinoma (PAC) but exhibits distinct biological features compared concomitant adenocarcinoma. In this study, we performed whole-exome, RNA, and DNA-methylation sequencing IDC-P, concurrent PAC lesions, adjacent normal tissues isolated from 22 radical prostatectomy specimens. Three evolutionary patterns IDC-P were identified: early divergent, late...

10.1158/0008-5472.can-23-1176 article EN Cancer Research 2023-10-17

Abstract Purpose: Fumarate hydratase–deficient renal cell carcinoma (FH-deficient RCC) is a rare and lethal subtype of kidney cancer. However, the optimal treatments molecular correlates benefits for FH-deficient RCC are currently lacking. Experimental Design: A total 91 patients with from 15 medical centers between 2009 2022 were enrolled in this study. Genomic bulk RNA-sequencing (RNA-seq) performed on 88 45 untreated RCCs, respectively. Single-cell RNA-seq was to identify biomarkers...

10.1158/1078-0432.ccr-23-2760 article EN cc-by-nc-nd Clinical Cancer Research 2024-03-21

<div>Abstract<p>Intraductal carcinoma of the prostate (IDC-P) is a lethal cancer subtype that generally coexists with invasive high-grade acinar adenocarcinoma (PAC) but exhibits distinct biological features compared concomitant adenocarcinoma. In this study, we performed whole-exome, RNA, and DNA-methylation sequencing IDC-P, concurrent PAC lesions, adjacent normal tissues isolated from 22 radical prostatectomy specimens. Three evolutionary patterns IDC-P were identified: early...

10.1158/0008-5472.c.7002666.v1 preprint EN 2024-01-02

<div>Abstract<p>Intraductal carcinoma of the prostate (IDC-P) is a lethal cancer subtype that generally coexists with invasive high-grade acinar adenocarcinoma (PAC) but exhibits distinct biological features compared concomitant adenocarcinoma. In this study, we performed whole-exome, RNA, and DNA-methylation sequencing IDC-P, concurrent PAC lesions, adjacent normal tissues isolated from 22 radical prostatectomy specimens. Three evolutionary patterns IDC-P were identified: early...

10.1158/0008-5472.c.7002666 preprint EN 2024-01-02
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