Xingming Zhang
- Renal cell carcinoma treatment
- Epigenetics and DNA Methylation
- Phagocytosis and Immune Regulation
- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Urologic and reproductive health conditions
- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- PARP inhibition in cancer therapy
- Ferroptosis and cancer prognosis
- Bladder and Urothelial Cancer Treatments
Sichuan University
2022-2024
West China Hospital of Sichuan University
2022-2024
Abstract Intraductal carcinoma of the prostate (IDC-P) is a lethal cancer subtype that generally coexists with invasive high-grade acinar adenocarcinoma (PAC) but exhibits distinct biological features compared concomitant adenocarcinoma. In this study, we performed whole-exome, RNA, and DNA-methylation sequencing IDC-P, concurrent PAC lesions, adjacent normal tissues isolated from 22 radical prostatectomy specimens. Three evolutionary patterns IDC-P were identified: early divergent, late...
Abstract Purpose: Fumarate hydratase–deficient renal cell carcinoma (FH-deficient RCC) is a rare and lethal subtype of kidney cancer. However, the optimal treatments molecular correlates benefits for FH-deficient RCC are currently lacking. Experimental Design: A total 91 patients with from 15 medical centers between 2009 2022 were enrolled in this study. Genomic bulk RNA-sequencing (RNA-seq) performed on 88 45 untreated RCCs, respectively. Single-cell RNA-seq was to identify biomarkers...
<p>Table S6</p>
<p>Table S4</p>
<p>Table S3</p>
<p>Supplementary Methods</p>
<p>Table S4</p>
<p>Table S1-revised</p>
<p>Supplementary Methods</p>
<p>Table S5</p>
<div>Abstract<p>Intraductal carcinoma of the prostate (IDC-P) is a lethal cancer subtype that generally coexists with invasive high-grade acinar adenocarcinoma (PAC) but exhibits distinct biological features compared concomitant adenocarcinoma. In this study, we performed whole-exome, RNA, and DNA-methylation sequencing IDC-P, concurrent PAC lesions, adjacent normal tissues isolated from 22 radical prostatectomy specimens. Three evolutionary patterns IDC-P were identified: early...
<p>Table S7</p>
<div>Abstract<p>Intraductal carcinoma of the prostate (IDC-P) is a lethal cancer subtype that generally coexists with invasive high-grade acinar adenocarcinoma (PAC) but exhibits distinct biological features compared concomitant adenocarcinoma. In this study, we performed whole-exome, RNA, and DNA-methylation sequencing IDC-P, concurrent PAC lesions, adjacent normal tissues isolated from 22 radical prostatectomy specimens. Three evolutionary patterns IDC-P were identified: early...
<p>Supplementary figure 1-15</p>
<p>Table S8</p>
<p>Supplementary figure 1-15</p>
<p>Table S5</p>
<p>Table S1-revised</p>
<p>Table S6</p>
<p>Table S2-revised</p>
<p>Table S8</p>
<p>Table S2-revised</p>
<p>Table S3</p>
<p>Table S7</p>