A5006760273- Renal cell carcinoma treatment
- Epigenetics and DNA Methylation
- Prostate Cancer Treatment and Research
- Phagocytosis and Immune Regulation
- Prostate Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Urologic and reproductive health conditions
- Bladder and Urothelial Cancer Treatments
- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- Inflammatory Biomarkers in Disease Prognosis
- Immune cells in cancer
- Stroke Rehabilitation and Recovery
- Retinal and Optic Conditions
- Transcranial Magnetic Stimulation Studies
- Bacteriophages and microbial interactions
- Microbial infections and disease research
- Financial Literacy, Pension, Retirement Analysis
- Mechanical Behavior of Composites
- Natural Fiber Reinforced Composites
- Electronic Packaging and Soldering Technologies
- Retinal Imaging and Analysis
- RNA modifications and cancer
- Pain Management and Treatment
- Housing Market and Economics
Sichuan University
2021-2025
West China Hospital of Sichuan University
2023-2025
Dalian University of Technology
2021-2025
Macao Polytechnic University
2025
Beijing Sport University
2024
Hangzhou Vocational and Technical College
2024
Hebei University of Architecture
2024
Beijing Institute of Technology
2023
Shenzhen Technology University
2023
Nankai University
2021-2023
TPS616 Background: Despite substantial advances in therapy over the past 20 years, median progression-free survival (mPFS) for advanced RCC patients treated with first-line tyrosine kinase inhibitors (TKIs) and immune checkpoint (ICIs) remains around months (Motzer RJ et al., NEJM 2021, Choueiri TK 2021). Moreover, subsequent treatments post-first-line progression exhibit inadequate efficacy. A phase Ib/II single-arm trial achieved a high objective response rate (ORR) lenvatinib plus...
ABSTRACT Background The advent of mobile health (mHealth) applications has fundamentally transformed the healthcare landscape, particularly within field ophthalmology, by providing unprecedented opportunities for remote diagnosis, monitoring, and treatment. Ocular surface diseases, including dry eye disease (DED), are most common diseases that can be detected mHealth applications. However, artificial intelligence (AI) systems ocular detection predominantly based on self‐reported data...
The integration of artificial intelligence (AI) into ophthalmic diagnostics has the potential to significantly enhance diagnostic accuracy and interpretability, thereby supporting clinical decision-making. However, a major challenge in AI-driven medical applications is lack transparency, which limits clinicians' trust automated recommendations. This study investigates application machine learning techniques by integrating knowledge graphs with contrastive utilizing "clinical profile" prompts...
By targeting advances in electronic packaging technologies, an innovative strategy has been applied for fabricating bump arrays. Herein, a 3D motion platform is equipped with pulsated orifice ejection method direct deposition. This enables on‐demand printing within the diameter range, achieving deposition accuracy of 6 μm at pitch 62 μm. The stable jetting process and precise significantly enhance repeatability fabrication. Notably, increase substrate temperature improves shear force bump....
Abstract Intraductal carcinoma of the prostate (IDC-P) is a lethal cancer subtype that generally coexists with invasive high-grade acinar adenocarcinoma (PAC) but exhibits distinct biological features compared concomitant adenocarcinoma. In this study, we performed whole-exome, RNA, and DNA-methylation sequencing IDC-P, concurrent PAC lesions, adjacent normal tissues isolated from 22 radical prostatectomy specimens. Three evolutionary patterns IDC-P were identified: early divergent, late...
Machine learning has emerged as a powerful tool for scientific discovery, enabling researchers to extract meaningful insights from complex datasets. For instance, it facilitated the identification of disease-predictive genes gene expression data, significantly advancing healthcare. However, traditional process analyzing such datasets demands substantial human effort and expertise data selection, processing, analysis. To address this challenge, we introduce novel framework, Team AI-made...
Abstract Purpose: Fumarate hydratase–deficient renal cell carcinoma (FH-deficient RCC) is a rare and lethal subtype of kidney cancer. However, the optimal treatments molecular correlates benefits for FH-deficient RCC are currently lacking. Experimental Design: A total 91 patients with from 15 medical centers between 2009 2022 were enrolled in this study. Genomic bulk RNA-sequencing (RNA-seq) performed on 88 45 untreated RCCs, respectively. Single-cell RNA-seq was to identify biomarkers...
We evaluated the effects of post-activation performance enhancement through flywheel exercise with varying inertial loads compared to traditional resistance on countermovement jump and muscle recruitment. In a randomized crossover design, 13 trained men completed four main experimental trials after three familiarization sessions. These conditions included trial consisting 5 sets 1 repetition using Smith machine (SM) squat at 90% 1RM, ergometer trials. Each protocol consisted 3 8 repetitions...
e16614 Background: Patients diagnosed with high-risk non-muscle invasive bladder cancer (HR-NMIBC) face a challenging prognosis, 5-year disease progression rate reaching up to 40%. The current standard treatment for HR-NMIBC involves transurethral resection of tumor (TURBT) followed by adjuvant intravesical Bacillus Calmette-Guérin (BCG) therapy. BCG therapy is reported exert anti-tumor therapeutic effects inducing both innate and adaptive immunity. Multiple studies have HER2 positivity in...
Myeloid-derived suppressor cells (MDSCs) enhance the proliferation of endothelial to stimulate angiogenesis. However, many aggressive malignant tumors do not have cell-dependent blood vessels in early stage and instead generate microcirculation by forming vasculogenic mimicry (VM). To date, relationship between MDSCs tumor remains focus ongoing studies. In this work, were co-cultured with mouse melanoma can VM formation cells. For targeting, doxycycline (DOX) was found selectively suppress...
Pinin is a moonlighting protein localized in desmosomes and nucleus. It could promote the growth of hepatocellular carcinoma. Whether this can induce epithelial-to-mesenchymal transition (EMT) malignant progression HCC unknown. This work found that prompts EMT vitro vivo. Further mechanism study increases level N6-methyladenosine (m6A) modification RNA by interacting with METTL3, which turn induces snail1 expression. These findings suggest regulating m6A and, thus, be potential anticancer...