A5062637578- Renal cell carcinoma treatment
- Epigenetics and DNA Methylation
- Phagocytosis and Immune Regulation
- Drug Transport and Resistance Mechanisms
- Cancer Immunotherapy and Biomarkers
- Advanced Drug Delivery Systems
- Drug Solubulity and Delivery Systems
- Optical Coatings and Gratings
- Nanoparticle-Based Drug Delivery
- Glycosylation and Glycoproteins Research
- Cancer Treatment and Pharmacology
- Bone and Dental Protein Studies
- Cancer Mechanisms and Therapy
- Health Policy Implementation Science
- HIV/AIDS drug development and treatment
- Optical Polarization and Ellipsometry
- Cancer Genomics and Diagnostics
- Dental Health and Care Utilization
- Metabolism and Genetic Disorders
- Dendrimers and Hyperbranched Polymers
- Multiple Myeloma Research and Treatments
- Pharmacological Effects and Toxicity Studies
- Ubiquitin and proteasome pathways
- GaN-based semiconductor devices and materials
- Renal and related cancers
Shaoxing People's Hospital
2025
Shaoxing University
2025
Sichuan University
2025
West China Hospital of Sichuan University
2025
West China Medical Center of Sichuan University
2024
Second Hospital of Anhui Medical University
2024
Anhui Medical University
2024
Shenyang Pharmaceutical University
2019-2022
Merck & Co., Inc., Rahway, NJ, USA (United States)
2021
International Society for Optics and Photonics
2018
Abstract Multiple myeloma (MM) is an incurable hematological malignancy with poor survival. Accumulating evidence reveals that lactylation modification plays a vital role in tumorigenesis. However, research on lactylation-related genes (LRGs) predicting the prognosis of MM remains limited. Differentially expressed LRGs (DELRGs) between and normal samples were investigated from Gene Expression Omnibus database. Univariate Cox regression LASSO analysis applied to construct gene signature...
Abstract Osteoarthritis has become a common degenerative joint disease, lacking clinical means to alleviate this disease. Melittin, taken from natural honeybee venom, possesses outstanding anti-inflammatory properties and great potential treat OA. However, its high toxicity hemolytic limit application. In work, biocompatible hydrogel was prepared extracellular matrix of rib cartilage, possessing fibrous mesh structure characteristics, which beneficial for melittin loading. It found that the...
Abstract The oral absorption of chemotherapeutical drugs is restricted by poor solubility and permeability, high first‐pass metabolism, gastrointestinal toxicity. Intestinal lymphatic transport lipophilic prodrugs a promising strategy to improve the delivery efficiency anticancer via entrapment into lipid formulation avoid metabolism. However, several basic principles have still not been clarified, such as intestinal digestibility stability on‐site tumor bioactivation. Herein,...
Islatravir (MK-8591) is a nucleoside reverse transcriptase translocation inhibitor in development for the treatment and prevention of HIV-1. The potential islatravir to interact with commonly co-prescribed medications was studied vitro. Elimination expected be balanced between adenosine deaminase–mediated metabolism renal excretion. did not inhibit uridine diphosphate glucuronosyltransferase 1A1 or cytochrome p450 (CYP) enzymes CYP1A2, 2B6, 2C8, 2C9, 2C19, 2D6, 3A4, nor it induce 3A4....
Abstract Purpose: Fumarate hydratase–deficient renal cell carcinoma (FH-deficient RCC) is a rare and lethal subtype of kidney cancer. However, the optimal treatments molecular correlates benefits for FH-deficient RCC are currently lacking. Experimental Design: A total 91 patients with from 15 medical centers between 2009 2022 were enrolled in this study. Genomic bulk RNA-sequencing (RNA-seq) performed on 88 45 untreated RCCs, respectively. Single-cell RNA-seq was to identify biomarkers...
Off-target drug release and insufficient delivery are the main obstacles for effective anticancer chemotherapy. Prodrug-based self-assembled nanoparticles bioactivated under tumor-specific conditions one of strategies to achieve on-demand tumor accumulation. Herein, stimuli-activable prodrugs designed yielding smart by combination triglyceride-mimic (TG-mimetic) prodrug structure disulfide bond. Surprisingly, these can self-assemble into uniform (NPs) with a high loading (over 40%)...
<div>AbstractPurpose:<p>Fumarate hydratase–deficient renal cell carcinoma (FH-deficient RCC) is a rare and lethal subtype of kidney cancer. However, the optimal treatments molecular correlates benefits for FH-deficient RCC are currently lacking.</p>Experimental Design:<p>A total 91 patients with from 15 medical centers between 2009 2022 were enrolled in this study. Genomic bulk RNA-sequencing (RNA-seq) performed on 88 45 untreated RCCs, respectively. Single-cell...
<p>Supplementary Figure 2. Treatment details and survival outcomes of patients with metastatic FH-deficient RCC. (A) Swimmer plot showing the treatment response duration each patient receiving first-line systemic treatments; (B) Progression-free for (C) Overall (OS) treatments.</p>
<p>Supplementary Figure 6. Validation of the FH-deficient RCC immune signature. (A) UMAP plot showing expression selected genes; (B) Correlations between six genes in signature and treatment response, significance differential (q value) was determined by two-sided Wilcoxon rank-sum test with Bonferroni FDR correction; (C) several related hallmark pathways, correction. *, q<0.05; **, q<0.01; ***, q<0.001; ****, q<0.0001.</p>
<p>Supplementary Figure 3. Forest plot showing the prognostic value of clinicopathologic and molecular features in patients treated with first-line ICI+TKI combination therapy. HR<1 indicates better survival comparator group, while HR>1 control group. TMB, tumor mutation burden; MUT, mutation; WT, wild type; TPS, proportion score; CCP, cell cycle progression; Sig., signature.</p>