A5101827306- RNA modifications and cancer
- Tendon Structure and Treatment
- Osteoarthritis Treatment and Mechanisms
- Shoulder Injury and Treatment
- Genetic Associations and Epidemiology
- Inflammasome and immune disorders
- Acupuncture Treatment Research Studies
- Bone Tissue Engineering Materials
- Genomics, phytochemicals, and oxidative stress
- Knee injuries and reconstruction techniques
- Bone Metabolism and Diseases
- Bone and Joint Diseases
- Sports injuries and prevention
- Cancer-related gene regulation
- Gene expression and cancer classification
- Cancer Immunotherapy and Biomarkers
- Viral-associated cancers and disorders
- Advanced Data Storage Technologies
- Rheumatoid Arthritis Research and Therapies
- Digital and Cyber Forensics
- Ferroptosis and cancer prognosis
- Bioinformatics and Genomic Networks
- Healthcare and Venom Research
- Traditional Chinese Medicine Studies
- Helicobacter pylori-related gastroenterology studies
Guangxi Medical University
2013-2025
First Affiliated Hospital of GuangXi Medical University
2013-2025
Shaoxing People's Hospital
2025
Shaoxing University
2025
Weill Cornell Medicine
2023
Cornell University
2023
ShenZhen People’s Hospital
2021
Auburn University
2017
Tongji University
2016
Hangzhou Dianzi University
2013-2014
Meniscal injuries have poor intrinsic healing capability and are associated with the development of osteoarthritis. Decellularized meniscus extracellular matrix (mECM) has been suggested to be efficacious for repair defect. However, main efforts date focused on concentration, crosslinking density anatomical region dependence mECM hydrogels regulation proliferation differentiation adult mesenchymal stem cells (MSCs) in vitro 2D or 3D culture. A systematic investigation understanding effect...
NF-E2-related factor 2 (Nrf2) is activated in several human malignancies. However, the role of Nrf2 gastric cancer (GC) remains incompletely understood. In this study, we therefore analyzed associations expression status with clinical features and chemotherapeutic resistance GC.A total 186 samples from GC patients who underwent gastrectomy were used for prognostic assessment. A further 142 cases received first-line combination chemotherapy applied investigation chemoresistance. The was...
Abstract Oxidative stress (OS) reactions are reported to be associated with oncogenesis and tumor progression. However, little is known about the potential diagnostic value of OS in gastric cancer (GC). This study identified hub genes prognosis progression GC illustrated underlying mechanisms. The transcriptome data corresponding clinical information were collected from Cancer Genome Atlas (TCGA) database. Aberrantly expressed between tumors adjacent normal tissues screened, 11...
Nifedipine is a voltage-gated calcium channel inhibitor widely used in the treatment of hypertension. has been reported to have antioxidant and anti-apoptotic effects promotes cell proliferation. However, nifedipine on oxidative stress apoptosis osteoarthritic (OA) chondrocytes are still unclear. In this study, we sought investigate whether alleviates OA through nuclear factor erythroid-2-related 2 (Nrf2) activation. The cytotoxicity against human was detected using...
Background: Osteoarthritis (OA) is a common chronic disease associated with aging and progressive joint dysfunction. Pyroptosis, new model of cell death. The effect pyroptosis on the progression osteoarthritis still being explored, specific mechanism unknown. Methods: OA dataset from GEO database website. Bioinformatics analysis was conducted to identify pyroptosis-related genes (PRGs), construct diagnostic model, subtypes. We established random forest (RF) as well nomogram differentially...
Abstract Osteoarthritis has become a common degenerative joint disease, lacking clinical means to alleviate this disease. Melittin, taken from natural honeybee venom, possesses outstanding anti-inflammatory properties and great potential treat OA. However, its high toxicity hemolytic limit application. In work, biocompatible hydrogel was prepared extracellular matrix of rib cartilage, possessing fibrous mesh structure characteristics, which beneficial for melittin loading. It found that the...
Abstract Background Observational studies have shown associations between psychiatric disorders and osteoarthritis (OA). However, the causal impact of different disorder types on specific sites remains unclear. This study aimed to comprehensively understand potential using Mendelian randomization (MR) analysis. Methods We collected data from genome‐wide association knee (KOA) ( n = 403,124), hip (HOA) 393,873), or (KHOA) 417,596), as well three disorders: bipolar 41,917), major depressive...
Aims: The purpose of the study was to evaluate safety and efficacy a modified posteromedial oblique incision (POI) in treatment posterior cruciate ligament (PCL) tibial avulsion fractures. Methods: A single-centre, single-arm, prospective study. Patients who met inclusion criteria were collected between September 2022 June 2024 at First Affiliated Hospital Guangxi Medical University. followed up endpoint, POI inferred by analysing follow-up data. Results: angle 67.20 ± 3.16°, |OM| 2.48 0.13...
Daphnetin (DAP) is a traditional Chinese drug usually used to treat cardiovascular diseases. Studies have confirmed the anti-inflammatory, antioxidant, anti-bacterial and insecticidal, anti-tumor neuro-protective effects of DAP. However, its anti-arthritic potential remains unexplored. The aim this study investigate in vitro vivo chondroprotective DAP.The effect DAP on primary rabbit chondrocytes was examined using recombinant human IL-1β for 24 h. For studies, rabbits were randomly divided...
Tumor occurrence, infiltration, and metastasis are significantly affected by the tumor microenvironment (TME). Increasing evidence has elucidated TME's clinical significance in prognostic assessment immunotherapy efficacy. Nonetheless, no studies have reported potential pyroptosis-related genes (PRGs) function TME immune cell infiltration. In this study, we systematically analyzed different PRG modification patterns 685 cutaneous melanoma (CM) cases. We comprehensively explored relationship...
Current engineered synthetic scaffolds fail to functionally repair and regenerate ruptured native tendon tissues, partly because they cannot satisfy both the unique biological biomechanical properties of these tissues. Ideal for regeneration need provide porous topographic structures cues necessary efficient infiltration tenogenic differentiation embedded stem cells. To obtain crimped scaffolds, highly aligned poly(l-lactide) fibers were prepared by electrospinning followed postprocessing....
Skin cutaneous melanoma (SKCM) is the most malignant tumor among skin cancers. Immunotherapy has shown a great role in advantageous prognosis of SKCM. However, only small percentage people can benefit from immunotherapy. To date, there been insufficient evidence to reveal prognostic value m6A SKCM and its relationship with infiltration immune cells efficacy immunotherapy.Here, we synthetically analyzed 23 regulators samples collected TCGA GEO databases. We defined three modification patterns...
Nowadays, a variety of Android user behavior information is automatically stored in SQLite to indicate when and what took places. In this paper, an approach reconstruct from YAFFS2 based on proposed. Based the storage mechanism file system structures SQLite, all records can be recovered image, regardless whether has been deleted or not YAFFS2, behaviors are parsed those records; then timeline constructed for visualizing time stamp it’s records. The evaluated experiment results show that...
Soft tissue sarcomas (STSs) are heterogeneous at the clinical with a variable tendency of aggressive behavior. In this study, we constructed specific DNA methylation-based classification to identify distinct prognosis-subtypes STSs based on methylation spectrum from TCGA database. Eventually, samples were clustered into 4 subgroups, and their survival curves each other. Meanwhile, in subgroup reflected differentially several features. Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes...