A5100345230- Glioma Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Radiomics and Machine Learning in Medical Imaging
- Meningioma and schwannoma management
- Ferroptosis and cancer prognosis
- Immune cells in cancer
- MicroRNA in disease regulation
- RNA modifications and cancer
- Brain Metastases and Treatment
- Vascular Malformations Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Cancer, Hypoxia, and Metabolism
- Pituitary Gland Disorders and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- MRI in cancer diagnosis
- Lymphoma Diagnosis and Treatment
- Intracranial Aneurysms: Treatment and Complications
- Epigenetics and DNA Methylation
- Cancer, Lipids, and Metabolism
- Inflammatory Biomarkers in Disease Prognosis
- Neurosurgical Procedures and Complications
- Cerebrospinal fluid and hydrocephalus
- Iron Metabolism and Disorders
- Genomics and Phylogenetic Studies
- Parkinson's Disease Mechanisms and Treatments
West China Hospital of Sichuan University
2016-2025
Henan Provincial People's Hospital
2013-2025
Hainan University
2025
Anhui Provincial Children's Hospital
2024-2025
Sichuan University
2014-2024
Guangdong Academy of Medical Sciences
2010-2024
Southern Medical University
2022-2024
Guangdong Provincial People's Hospital
2022-2024
Jiangxi University of Traditional Chinese Medicine
2024
State Key Laboratory of Biotherapy
2023
Abstract Diffuse midline glioma-H3K27M mutant (DMG) and glioblastoma (GBM) are the most lethal brain tumors that primarily occur in pediatric adult patients, respectively. Both exhibit significant heterogeneity, shaped by distinct genetic/epigenetic drivers, transcriptional programs including RNA splicing, microenvironmental cues glioma niches. However, spatial organization of cellular states niche-specific regulatory remain to be investigated. Here, we perform a profiling DMG GBM combining...
Multi-modal therapeutics are emerging for simultaneous diagnosis and treatment of cancer. Polymeric carriers often employed loading multiple drugs due to their versatility controlled release these in response a tumor specific microenvironment. A theranostic nanomedicine was designed prepared by complexing small gadolinium chelate, conjugating chemotherapeutic drug PTX through cathepsin B-responsive linker covalently bonding fluorescent probe pheophorbide (Ppa) with branched glycopolymer. The...
Diffuse midline glioma, H3 K27M-mutant (H3 K27M-mt DMG), is a rare and highly aggressive tumor that more common in children than adults. Few studies have compared the differences between pediatric adult patients with this tumor. We here report our retrospective study of 94 70 cases diffuse glioma. Surgical samples were analyzed by routine histopathology immunohistochemistry for K27M, IDH1 R132H, ATRX, p53, OLIG2, glial fibrillary acidic protein, Ki-67; Sanger sequencing hot mutation spots...
The midgut microbiota of Aedes aegypti is crucial for the mosquito’s development, nutrition, and immunity. However, its communities are also distinctively influenced by colonization different microorganisms, influencing susceptibility to pathogens transmission capacity. In this study, we investigated effects infections with Escherichia coli, Staphylococcus aureus, Beauveria bassiana on microbial composition Ae. aegypti. These microorganisms were inoculated into midguts third-instar larvae...
Sorafenib is the first‑line treatment for advanced hepatocellular carcinoma (HCC). Since many HCC patients experience drug resistance, there an urgent need to discover more effective therapeutic strategies overcome resistance. Long non‑coding RNAs (lncRNAs) play important role in tumor However, research on of lncRNA H19 sorafenib resistance quite limited. In present study, CCK‑8 assay, RT‑qPCR, EdU staining, immunofluorescence and western blot analysis were used detect effect cells....
Background Glioma is the most common primary brain tumor in adults and accounts for more than 70% of malignancies. Lipids are crucial components biological membranes other structures cells. Accumulating evidence has supported role lipid metabolism reshaping immune microenvironment (TME). However, relationship between TME glioma remain poorly described. Materials methods The RNA-seq data clinicopathological information patients were downloaded from Cancer Genome Atlas (TCGA) Chinese (CGGA)....
Abstract Background Post-stroke seizures and epilepsy can affect patients' quality of life, increase mortality in stroke patients, patient outcomes, are associated with higher medical expenditures. However, little is known about the risk factors that influence onset post-stroke epilepsy. Aim We aimed to summarize assess credibility evidence potential for after stroke. Design Qualitative synthesis random-effects model appraisal using Grading Recommendations, Assessment, Development,...
Quantification of nonlinear interactions between two nonstationary signals presents a computational challenge in different research fields, especially for assessments physiological systems. Traditional approaches that are based on theories stationary cannot resolve nonstationarity-related issues and, thus, reliably assess In this review we discuss new technique called multimodal pressure flow (MMPF) method utilizes Hilbert-Huang transformation to quantify interaction cerebral blood velocity...
The current TNM staging system plays a central role in lung adenocarcinoma (LUAD) prognosis. However, it may not adequately stratify the risk of tumor recurrence. With aid gene expression profiling, we identified 31 lncRNAs whose expressions tissues could be used as indicator for guidance cancer therapy. This exploratory analysis shed new light on identification potential prognostic factors.A survival prediction scoring model was developed from data that are publicly available Cancer Genome...
The urokinase-type plasminogen activator(PLAU) and its receptor PLAUR participate in a series of cell physiological activities on the extracellular surface. Abnormal expression PLAU is associated with tumorigenesis. This study aims to evaluate prognostic value PLAU/PLAUR transcription glioma explore how they affect generation progression glioma. In this study, online databases are applied, such as Oncomine, GEPIA, CGGA, cBioPortal, LinkedOmics. Overexpression was found be significantly...
ABSTRACT Acute myeloid leukemia (AML) is a malignant tumor of blood cells, which seriously interferes with the generation normal cells. Although miR‐186‐5p diminished in AML, its exact mechanism not well understood. and PD‐L1 levels AML cells (HL‐60, KG‐1, TF‐1a, MOLT‐3) subcutaneous tissue were discovered through qRT‐PCR Western blot. miR‐186‐5 p combining sites foreseen by database verified dual luciferase immunoprecipitation experiments. overexpression or knockdown cocultured CD4 + CD8 T...
Cerebral autoregulation (CA) is an important vascular control mechanism responsible for relatively stable cerebral blood flow despite changes of systemic pressure (BP). Impaired CA may leave brain tissue unprotected against potentially harmful effects BP fluctuations. It generally accepted that less effective or even inactive at frequencies >∼0.1 Hz. Without any physiological foundation, this concept based on studies quantified the coupling between and velocity (BFV) using transfer function...
Conventional procedures for the intraoperative assessment of breast cancer sentinel lymph nodes (SLNs) are frozen section (FS) and touch imprint cytology (TIC). The one-step nucleic acid amplification (OSNA) assay is a novel molecular technique. aim this study was to evaluate optimal approach by comparing OSNA assay, FS, TIC. Five hundred fifty-two consecutive patients were enroled from five centers in China. SLNs cut into alternating 2 mm blocks. odd blocks tested intraoperatively, even...
Oligodendrocytes ensheath axons to form compact insulating multilamellar structures known as myelin.Tmem10 is a novel type I transmembrane glycoprotein that highly expressed in oligodendrocytes and whose biological function remains largely unknown.Furthermore, the expression pattern of Tmem10 matter some controversy.Given inconsistency its lack validated specific antibodies, not widely accepted marker for mature oligodendrocytes.As means solve these problems aid future studies...