A5114626840- Prenatal Screening and Diagnostics
- Blood groups and transfusion
- RNA modifications and cancer
- SARS-CoV-2 and COVID-19 Research
- Hemoglobinopathies and Related Disorders
- COVID-19 Clinical Research Studies
- Mycobacterium research and diagnosis
- Rheumatoid Arthritis Research and Therapies
- Minimally Invasive Surgical Techniques
- Genetic Syndromes and Imprinting
- Wound Healing and Treatments
- Cancer Genomics and Diagnostics
- Autoimmune and Inflammatory Disorders Research
- SARS-CoV-2 detection and testing
- Genomic variations and chromosomal abnormalities
- Systemic Lupus Erythematosus Research
- Silk-based biomaterials and applications
- Colorectal Cancer Surgical Treatments
- Electrospun Nanofibers in Biomedical Applications
- Multiple and Secondary Primary Cancers
- Hepatitis C virus research
- Parvovirus B19 Infection Studies
- 3D Printing in Biomedical Research
- Cancer Cells and Metastasis
- Neurogenetic and Muscular Disorders Research
Sichuan Cancer Hospital
2022-2024
BGI Genomics
2019-2022
BGI Group (China)
2019-2022
Dazhou Central Hospital
2020
University of Copenhagen
2020
Abstract Background Rheumatoid arthritis (RA) is a chronic, systemic autoimmune inflammatory disease, the pathogenesis of which not clear. Clinical remission, or decreased disease activity, aim treatment for RA. However, our understanding activity inadequate, and clinical remission rates RA are generally poor. In this study, we used multi-omics profiling to study potential alterations in rheumatoid with different levels. Methods Fecal plasma samples from 131 patients 50 healthy subjects were...
Rheumatoid arthritis (RA) is a chronic inflammatory joint disease, which associated with progressive disability, systemic complications, and early death. But its etiology pathogenesis are not fully understood. We aimed to investigate the alterations in plasma metabolite profiles, gut bacteria, fungi their role of them RA.Metabolomics profiling from 363 participants including RA (n = 244), lupus erythematosus (SLE, n 50), healthy control (HC, 69) were performed using ultra-high performance...
Background: The existence of maternal malignancy may cause false-positive results or failed tests NIPT. Though recent studies have shown multiple chromosomal aneuploidies (MCA) are associated with malignancy, there is still no effective solution to identify cancer patients from pregnant women MCA using We aimed develop a new method effectively detect in NIPT and random forest classifier the tissue origin common types. Methods: For examination, 496 participants via were enrolled January 2016...
Abstract Backgrounds: Laparoscopic surgery, robot-assisted surgery and open are the most commonly consumed surgical techniques in daily living. Considering that recent years, situation of choosing laparoscopic to treat rectal cancer China is prosperous. Meanwhile, researches lacked comparison part between 2, so we will systematically compare clinical efficacy resection traditional for cancer. Methods analysis: We search Clinical research literature published before January 2020 PubMed,...
Abstract Objective We aimed to investigate the validity of noninvasive prenatal diagnosis (NIPD) based on direct haplotype phasing without proband and its feasibility for clinical application in case Duchenne Muscular Dystrophy (DMD). Methods Thirteen singleton-pregnancy families affected by DMD were recruited. Firstly, we resolved maternal haplotypes each family performing targeted linked-read sequencing their high molecular weight DNA, respectively. Then, identified SNPs gene all carrier...
ABSTRACT Purpose Genome sequencing (GS) is a powerful tool for postnatal genetic diagnosis, but relevant clinical studies in the field of prenatal diagnosis are few. We aimed to evaluate feasibility GS as first-line approach and compare its value with chromosomal microarray analysis (CMA) plus exome (ES) sequential testing. Methods applied trio (∼40-fold) parallel CMA ES investigate basis structural or growth anomalies 111 fetuses compared their results. Results covered all variants 22...
Abstract COVID-19 has become a global pandemic, but with very little is known about it. In this single-centered, retrospective study, we collected all 37 confirmed cases of diagnosed in Dazhou, Sichuan, China from January 23 to February 25, 2020，and analyzed the demographic, clinical, and laboratory data. All were either imported Wuhan transmitted family clusters. The average age patients was 45.76 ± 13.1 years. duration pharyngeal swabs 20.65 6.7 days. Four (10.8%) asymptomatic, 33 (89.1%)...