A5076157937- Nanoplatforms for cancer theranostics
- Photodynamic Therapy Research Studies
- Luminescence and Fluorescent Materials
- Advanced biosensing and bioanalysis techniques
- Advanced Nanomaterials in Catalysis
- Nanoparticle-Based Drug Delivery
- Cancer, Hypoxia, and Metabolism
- Molecular Sensors and Ion Detection
- Sulfur Compounds in Biology
- Click Chemistry and Applications
- Photochromic and Fluorescence Chemistry
- Extracellular vesicles in disease
- Nanocluster Synthesis and Applications
- RNA Interference and Gene Delivery
- Advanced Photocatalysis Techniques
- Autophagy in Disease and Therapy
- Porphyrin and Phthalocyanine Chemistry
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- RNA modifications and cancer
- Lanthanide and Transition Metal Complexes
- Cancer-related molecular mechanisms research
- Gut microbiota and health
- CRISPR and Genetic Engineering
- Immune cells in cancer
Dalian University
2016-2025
Dalian University of Technology
2016-2025
Shanghai University of Traditional Chinese Medicine
2023-2025
Tongji University
2023-2025
Nanjing Normal University
2020-2025
Beijing University of Chinese Medicine
2015-2025
Guangzhou University of Chinese Medicine
2024-2025
Zhongyuan University of Technology
2024-2025
Smart Material (Germany)
2024-2025
State Key Laboratory of Fine Chemicals
2025
Abstract Traditional photothermal therapy requires high‐intensity laser excitation for cancer treatments due to the low conversion efficiency (PCE) of agents (PTAs). PTAs with ultra‐high PCEs can decrease required excited light intensity, which allows safe and efficient in deep tissues. In this work, a PTA is synthesized high PCE 88.3% based on BODIPY scaffold, by introducing CF 3 “barrier‐free” rotor meso ‐position (tfm‐BDP). both ground state, moiety tfm‐BDP has no energy barrier...
Hydrogen sulfide (H2S) is emerging as an important gasotransmitter but remains difficult to study. Here we report a novel two-photon fluorescent probe with NIR emission for H2S detection. It was successfully used realize imaging in bovine serum, living cells, tissues well mice.
Strong oxygen dependence, poor tumor targeting, and limited treatment depth have been considered as the "Achilles' heels" facing clinical usage of photodynamic therapy (PDT). Different from common approaches, here, we propose an innovative tactic by using photon-initiated dyad cationic superoxide radical (O2–•) generator (ENBOS) featuring "0 + 1 > 1" amplification effect to simultaneously overcome these drawbacks. In particular, taking advantage Förster resonance energy transfer theory,...
An amphiphilic Ru-containing block copolymer is used as a photoactivated polymetallodrug for anticancer phototherapy. The self-assembles into nanoparticles, which can accumulate at tumor sites in mouse model. Red light irradiation of the nanoparticles releases Ru complexes and generates cytotoxic 1 O2 , both inhibit growth.
The recurrence of malignant tumors is mostly caused by incompleted surgical resection. Especially, it difficult for surgeons to detect and accurately remove metastatic predominantly using visual examination palpation owing the lack effective means specifically distinguish boundary range between normal tumor tissues. Thus, development activated fluorescent probe with superior tumor-to-normal (T/N) tissue ratios particularly urgent in clinics. In view CD13/aminopeptidase N (APN) regarded as a...
Abstract Photodynamic therapy (PDT) is clinically promising in destructing primary tumors but ineffective against distant metastases. This study reports the use of immunogenic nanoparticles mediated combination PDT and magnetic hyperthermia to synergistically augment anti‐metastatic efficacy immunotherapy. Janus nanobullets integrating chlorine e6 (Ce6) loaded, disulfide‐bridged mesoporous organosilica bodies with heads (M‐MONs@Ce6) are tailored for redox/pH‐triggered photosensitizer release...
It remains a considerable challenge to realize complete tumor suppression and avoid regrowth by rational design of photosensitizers (PSs) improve their photon utilization. In this Article, we provide molecular (Icy-NBF) based on the oxygen-content-regulated deactivation process excited states. presence overexpressed nitroreductase in hypoxic cancer cells, Icy-NBF is reduced converted into molecule with same skeleton (Icy-NH2), which PS under 808 nm light irradiation proceeds via different...
A Se-containing heptamethine cyanine dye based fluorescent probe was successfully developed and used for HClO detection with rapid response high selectivity on aggregation behavior. The could react significant change in its fluorescence profile, which makes it practical detecting fetal bovine serum living mice.
Based on modulation of the conjugated polymethine π-electron system a cyanine dye derivative, ratiometric near-infared fluorescent probe (Cy7A) for hydrazine (N2H4) has been designed and synthesized. Cy7A can be selectively hydrazinolysized with great changes in its excitation/emission profiles, which makes it possible to detect N2H4 water samples living cells and, first time, visualize mice.
Background and aims Liver fibrosis is a wound-healing response that disrupts the liver architecture function by replacing functional parenchyma with scar tissue. Recent progress has advanced our knowledge of this scarring process, but detailed mechanism far from clear. Methods The fibrotic specimens patients HLF (hepatic leukemia factor) PB/PB mice were used to assess expression role in fibrosis. Primary murine hepatic stellate cells (HSCs) human HSC line Lx2 investigate impact on activation...
Photodynamic therapy is considered as a promising treatment for cancer, but still faces several challenges.
The efficacy and safety of multikinase inhibitor anlotinib have been confirmed in the treatment advanced non-small cell lung cancer (NSCLC). However, direct functional mechanisms tumor lethality mediated by were not fully elucidated, underlying related to resistance remain largely elusive.Cell viability, colony formation, apoptosis growth assays performed examine effect on cells vitro vivo. punctate patterns LC3-I/II detected confocal microscopy. HUVECs motility was using Transwell scratch...
Endoplasmic reticulum (ER) stress, caused by overproduction of reactive oxygen species (ROS), has been shown to be responsible for immunogenic cell death (ICD). Seeking ROS generator targeting ER is an optimal solution efficiently induce stress. Despite clear indications demand ER-targeting photosensitizer, the alternative chemical tools remain limited. Herein, first ER-localizable ICD photoinducer using thio-pentamethine cyanine dye (TCy5) stress under mild near-infrared (NIR) irradiation...
Heavy-atom-based photosensitizers usually exhibit shortened triplet-state lifetimes, which is not ideal for hypoxic tumor photodynamic therapy. Although several heavy-atom-free possess long the clinical applicability limited by their short excitation wavelengths, poor photon capture abilities, and intrinsically hydrophobic structures. Herein we developed a novel NIR photosensitizer design strategy introducing sterically bulky electron-rich moieties at meso position of pentamethine cyanine...