A5101953584- Nanoplatforms for cancer theranostics
- Luminescence and Fluorescent Materials
- Molecular Sensors and Ion Detection
- Advanced biosensing and bioanalysis techniques
- Photodynamic Therapy Research Studies
- Sulfur Compounds in Biology
- Engineering Education and Curriculum Development
- RNA Interference and Gene Delivery
- Lipid metabolism and biosynthesis
- Cancer, Hypoxia, and Metabolism
- Advanced Computational Techniques and Applications
- Green IT and Sustainability
- Education and Work Dynamics
- HVDC Systems and Fault Protection
- Ideological and Political Education
- High-Voltage Power Transmission Systems
- BIM and Construction Integration
- Online and Blended Learning
- Emotional Intelligence and Performance
- Educational Technology and Assessment
- Electromagnetic Simulation and Numerical Methods
- Inflammasome and immune disorders
- Microwave Engineering and Waveguides
- Innovative Educational Techniques
- Impact of Technology on Adolescents
State Forestry and Grassland Administration
2025
Zhejiang A & F University
2025
Zhejiang Financial College
2024
Wenzhou Medical University
2022-2024
Guiyang College of Traditional Chinese Medicine
2024
Chongqing Jiulongpo People's Hospital
2023
Ministry of Education of the People's Republic of China
2023
Qilu Hospital of Shandong University
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
Wuhan Pulmonary Hospital
2023
Abstract Mitochondrial polarity strongly influences the intracellular transportation of proteins and interactions between biomacromolecules. The first fluorescent probe capable ratiometric imaging mitochondrial is reported. probe, termed BOB, has two absorption maxima ( λ abs =426 561 nm) emission maxima—a strong green em =467 a weak red (642 nm in methanol)—when excited at 405 nm. However, only markedly sensitive to changes, thus providing fluorescence response with good linear relationship...
Photodynamic therapy is considered as a promising treatment for cancer, but still faces several challenges.
Monitoring fluctuations in enzyme overexpression facilitates early tumor detection and excision. An AIEgen probe (DQM-ALP) for the imaging of alkaline phosphatase (ALP) activity was synthesized. The consists a quinoline-malononitrile (QM) core decorated with hydrophilic phosphate groups as ALP-recognition units. rapid liberation DQM-OH aggregates presence ALP resulted aggregation-induced fluorescence. up-regulation expression cells imaged using DQM-ALP. permeated into 3D cervical liver...
When SO2 is inhaled through the respiratory tract into body, it can be easily hydrated to sulfite (SO32–) and bisulfate (HSO3–) ions. They are widely used as essential preservatives for foods, beverages, pharmaceutical products. Exposure high doses of induces a large number diseases relevant lung cancer, cardiovascular diseases, many neurological disorders, they involve in various physiology pathological processes mitochondria cell apparatus. In this work, new fluorescent probe CY-SO2...
An integrative metalloproteomic approach to unveil the role of antimicrobial metals in general using bismuth as an example.
Abstract Mitochondrial polarity strongly influences the intracellular transportation of proteins and interactions between biomacromolecules. The first fluorescent probe capable ratiometric imaging mitochondrial is reported. probe, termed BOB, has two absorption maxima ( λ abs =426 561 nm) emission maxima—a strong green em =467 a weak red (642 nm in methanol)—when excited at 405 nm. However, only markedly sensitive to changes, thus providing fluorescence response with good linear relationship...
The occurrence of and development in the early pathological stage pancreatic cancer has proved to be associated with microRNAs. However, it remains a great challenge directly monitor low-expression, downregulation of, microRNA among living cells, tissues, serum samples. In this work, Staudinger reduction is first applied intracellular detection, establishing set smart hybridization-mediated probes (HMSR-probe) which contain designed oligonucleotide sequences. Meanwhile, 40 samples (healthy...
App usage prediction, i.e. which apps will be used next, is very useful for smartphone system optimization, such as operating resource management, battery energy consumption and user experience improvement well. However, it still challenging to achieve prediction of high accuracy. In this paper, we propose a novel framework app called AppUsage2Vec, inspired by Doc2Vec. It models records considering the contribution different apps, personalized characteristics, temporal context. We measure...
Nitroxyl (HNO), one electron reduced and protonated form of nitric oxide (NO), plays vital in various biological functions pharmacological activities, such as mediating β-agonist dobutamine, inhibiting the activity enzyme treating cardiovascular diseases. However, accurate mechanism HNO living cells is not thoroughly understood due to lacking effective methods. In this work, a novel two-photon fluorescent probe TP-HNO was designed synthesized based on 6-hydroxyl-quinonline-2-benzothiazole...
Highly efficient triplet photosensitizers (PSs) have attracted increasing attention in cancer photodynamic therapy where photo-induced reactive oxygen species (ROSs, such as singlet oxygen) are produced via singlet-triplet intersystem crossing (ISC) of the excited photosensitizer to kill cells. However, most PSs exhibit fatal defect a generally less-than-1% efficiency ISC and low yield ROSs, this strongly impedes their clinical application. In current work, new strategy enhance high...
Cell survival or death is critical for cardiac function. Myocardial pyroptosis, as a newly recognized programmed cell death, remains poorly understood in sepsis. In this study, we evaluated the effect of aldehyde dehydrogenase (ALDH2) on myocardial pyroptosis and revealed underlying mechanisms We established septic shock mice model by intraperitoneal injection Lipopolysaccharide (LPS, 15 mg/kg) 12 h before sacrifice. It was found that significantly inhibited NOD-like receptor protein 3...
Sodium polysulfides (Na2Sn, n > 1) as important raw materials in the chemical industry can afford hydrogen (H2Sn, under physiological conditions. Hydrogen are reactive sulfide species that play crucial roles biological systems. The simple detection of H2Sn solution and biosystems becomes very a consequence foregoing applications. Herein, we report NIR fluorescent chemodosimeter, Cy-Sn, displaying turn-on fluorescence after reaction with H2Sn, which exhibits good selectivity sensitivity...
Telomerase participation causes microRNA circulation in a testing system, which reliably enhances the difference between cancer cells and normal cells.
A new near-infrared probe (<bold>Cy-B</bold>) was applied to monitor spontaneous hydrogen peroxide in an autophagy process induced by the stimulation of rapamycin.
Abstract Monitoring fluctuations in enzyme overexpression facilitates early tumor detection and excision. An AIEgen probe (DQM‐ALP) for the imaging of alkaline phosphatase (ALP) activity was synthesized. The consists a quinoline‐malononitrile (QM) core decorated with hydrophilic phosphate groups as ALP‐recognition units. rapid liberation DQM‐OH aggregates presence ALP resulted aggregation‐induced fluorescence. up‐regulation expression cells imaged using DQM‐ALP. permeated into 3D cervical...
Bi-binding motifs were mined in<italic>H. pylori</italic>by Bi-IMAC and the putative Bi-targets analyzed by structural bioinformatics approaches.