A5051519108- Nanoplatforms for cancer theranostics
- Turbomachinery Performance and Optimization
- Aerodynamics and Fluid Dynamics Research
- Advanced Nanomaterials in Catalysis
- Fluid Dynamics and Turbulent Flows
- Cloud Computing and Resource Management
- Luminescence and Fluorescent Materials
- Advanced biosensing and bioanalysis techniques
- Extracellular vesicles in disease
- Photodynamic Therapy Research Studies
- Phase-change materials and chalcogenides
- Embedded Systems and FPGA Design
- Luminescence Properties of Advanced Materials
- Sensor Technology and Measurement Systems
- Cloud Computing and Remote Desktop Technologies
- Opportunistic and Delay-Tolerant Networks
- Mobile Ad Hoc Networks
- Phagocytosis and Immune Regulation
- Caching and Content Delivery
- Metallurgical Processes and Thermodynamics
- Icing and De-icing Technologies
- Fault Detection and Control Systems
- Mineral Processing and Grinding
- Immune cells in cancer
- Cancer, Hypoxia, and Metabolism
Zhejiang Sci-Tech University
2025
Dalian University
2020-2024
Dalian University of Technology
2013-2024
Smart Material (Germany)
2024
Harbin Engineering University
2012-2023
Nankai University
2023
Kunming University of Science and Technology
2002-2023
Liaoning Cancer Hospital & Institute
2022
North University of China
2019
China University of Geosciences
2014
The recurrence of malignant tumors is mostly caused by incompleted surgical resection. Especially, it difficult for surgeons to detect and accurately remove metastatic predominantly using visual examination palpation owing the lack effective means specifically distinguish boundary range between normal tumor tissues. Thus, development activated fluorescent probe with superior tumor-to-normal (T/N) tissue ratios particularly urgent in clinics. In view CD13/aminopeptidase N (APN) regarded as a...
Endoplasmic reticulum (ER) stress, caused by overproduction of reactive oxygen species (ROS), has been shown to be responsible for immunogenic cell death (ICD). Seeking ROS generator targeting ER is an optimal solution efficiently induce stress. Despite clear indications demand ER-targeting photosensitizer, the alternative chemical tools remain limited. Herein, first ER-localizable ICD photoinducer using thio-pentamethine cyanine dye (TCy5) stress under mild near-infrared (NIR) irradiation...
Conventional photocages only respond to short wavelength light, which is a significant obstacle developing efficient phototherapy in vivo. The development of activated by near-infrared (NIR) light at wavelengths from 700 950 nm important for vivo studies but remains challenging. Herein, we describe the synthesis photocage based on ruthenium (Ru) complex with NIR light-triggered photocleavage reaction. commercial anticancer drug, tetrahydrocurcumin (THC), was coordinated RuII center create...
In this contribution, based on a “step-by-step” molecular design strategy, novel NIR amphiphilic AIEgen <bold>TPA-S-TPP</bold> with triplet lifetime of 11.43 μs and surmounting the shackle MMP was successfully fabricated for amplified tumor ablation.
Responsive nanosystems for tumor treatment with high specificity and sensitivity have aroused great attention. Herein, we develop a microenvironment responsive near-infrared (NIR)-activatable theranostic nanoreactor imaging-guided anticancer therapy. The (SnO
The activation of sequential events in the cancer-immunity cycle (CIC) is crucial for achieving effective antitumor immunity. However, formidable challenges, such as innate and adaptive immune resistance, along with off-target adverse effects nonselective immunomodulators, persist. In this study, a tumor-selective nano-regulator named PNBJQ has been presented, focusing on targeting two nonredundant nodes: inducing immunogenic cancer cell death abrogating resistance to fully activate...
Smart nanotheranostic systems (SNSs) have attracted extensive attention in antitumor therapy. Nevertheless, constructing SNSs with disease diagnosis ability, improved drug delivery efficiency, inherent imaging performance, and high treatment efficiency remains a scientific challenge. Herein, ultrasmall tin dioxide (SnO2) was assembled upconversion nanoparticles (UCNPs) to form mesoporous nanocapsules by an situ hydrothermal deposition method, followed loading doxorubicin (DOX) modification...
As the least toxic heavy metal, monoelemental bismuth nanomaterials with several superiorities are ideal theranostic agents. However, nanoparticles easily oxidized by oxygen in air or media, limiting their clinical application. In contrast, oxidization of Bi0 to Bi3+ can activate chemodynamic therapy (CDT) transferring endogenous H2O2 into •OH. Herein, a well-designed Bi-DMSNs@PCM nanosystem was prepared via situ growth Bi nanodots and coating phase-change material (PCM) on surface dendritic...
Abstract The clinical application of photodynamic therapy (PDT) is limited by oxygen‐dependence and side effects caused photosensitizer residues. Photoinitiators based on the H‐abstraction reaction can address these challenges because they generate alkyl radical‐killing cells independently oxygen undergo rapid bleaching following H‐abstraction. Nonetheless, development photoinitiators for PDT has been impeded absence effective design strategies. Herein, we have developed aryl‐ketone...
Compact, mechanically robust, and cost-effective mid-infrared (MIR) light sources are key components in portable field-deployable gas sensors. Capitalizing on an efficient energy transfer mechanism between Co2+ Fe2+, we have demonstrated for the first time, to best of our knowledge, that ultrabroadband 2.5-5.5 µm MIR emission can be achieved at room temperatures chalcogenide (ChG) glasses pumped by a commercially available erbium-doped fiber amplifier emitting 1.57 µm. These MIR-transparent...
Critically refracted longitudinal (LCR) waves are commonly used to evaluate the residual stress of a material. The utilization LCR is advantageous in that these not sensitive texture Thus, can be considered as bulk mode and penetrate into material well below its surface. However, while measuring stress, precision wave travel-time influenced by several uncertain factors. In order further improve accuracy test results, we developed measurement approach based on three aspects. First, distances...
Abstract The difficulty of endpoint determination in basic oxygen furnace (BOF) steelmaking lies achieving accurate real-time measurements carbon content and temperature. For the characteristics serious nonlinearity between process data, deep learning can perform excellent nonlinear feature representation for complex structural data. However, there is a drift phenomenon BOF steelmaking, existing learning-based soft sensor models cannot adapt to changes samples, which may lead their...