A5081323617- Nanoplatforms for cancer theranostics
- Photodynamic Therapy Research Studies
- Nanoparticle-Based Drug Delivery
- Numerical methods in engineering
- Advanced Nanomaterials in Catalysis
- Advanced biosensing and bioanalysis techniques
- Advanced Numerical Methods in Computational Mathematics
- Click Chemistry and Applications
- Immunotherapy and Immune Responses
- Radiomics and Machine Learning in Medical Imaging
- Thyroid Cancer Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Luminescence and Fluorescent Materials
- Dental Erosion and Treatment
- Catalytic Alkyne Reactions
- Cyclopropane Reaction Mechanisms
- Immune cells in cancer
- Phagocytosis and Immune Regulation
- Electrospun Nanofibers in Biomedical Applications
- Nanocluster Synthesis and Applications
- Angiogenesis and VEGF in Cancer
- Adenosine and Purinergic Signaling
- Selenium in Biological Systems
- Electromagnetic wave absorption materials
- Vitamin K Research Studies
Northeastern University
2024-2025
National University of Singapore
2025
Suzhou Research Institute
2025
Ansteel (China)
2024
Sinosteel (China)
2024
Qingdao University
2020-2023
Dalian University of Technology
2020-2023
Dalian University
2020-2023
Zhengzhou University
2017-2023
The Seventh Affiliated Hospital of Sun Yat-sen University
2021
Endoplasmic reticulum (ER) stress, caused by overproduction of reactive oxygen species (ROS), has been shown to be responsible for immunogenic cell death (ICD). Seeking ROS generator targeting ER is an optimal solution efficiently induce stress. Despite clear indications demand ER-targeting photosensitizer, the alternative chemical tools remain limited. Herein, first ER-localizable ICD photoinducer using thio-pentamethine cyanine dye (TCy5) stress under mild near-infrared (NIR) irradiation...
The development of highly effective photosensitizers (PSs) for photodynamic therapy remains a great challenge at present. Most PSs rely on the heavy-atom effect or spin-orbit charge-transfer intersystem crossing (SOCT-ISC) to promote ISC, which brings about additional cytotoxicity, and latter is susceptible interference solvent environment. Herein, an immanent universal property named photoinduced molecular vibrational torsion (PVT)-enhanced coupling (PVT-SOC) in has been first revealed. PVT...
Highly efficient triplet photosensitizers (PSs) have attracted increasing attention in cancer photodynamic therapy where photo-induced reactive oxygen species (ROSs, such as singlet oxygen) are produced via singlet-triplet intersystem crossing (ISC) of the excited photosensitizer to kill cells. However, most PSs exhibit fatal defect a generally less-than-1% efficiency ISC and low yield ROSs, this strongly impedes their clinical application. In current work, new strategy enhance high...
Efficiency of standard chemotherapy is dramatically hindered by intrinsic multidrug resistance (MDR). Recently, to amplify therapeutic efficacy, photodynamic therapy (PDT)-induced mitochondrial dysfunction decorating targeting moieties on nanocarriers has obtained considerable attention. Nevertheless, low efficiency, complex synthesis routes, and difficulty in releasing contents become the major obstacles further clinical application. Herein, an ingenious liposomal-based nanomedicine (L@BP)...
Pentamethyl cyanine dyes are promising fluorophores for fluorescence sensing and imaging. However, advanced biomedical applications require enhanced control of their excited-state properties. Herein, a synthetic approach attaching aryl substituents at the C2' position thio-pentamethine (TCy5) dye structure is reported first time. C2'-aryl substitution enables regulation both twisted intramolecular charge transfer (TICT) photoinduced electron (PET) mechanisms to be regulated in excited state....
On the basis of Lewis acid-catalyzed Friedel-Crafts alkylation between 1-acyl-2-arylcyclopropanecarboxylate esters and electron-rich phenols, a Sc(OTf)3 catalyzed cascade [4 + 2]-annulation reaction was developed for direct synthesis polysubstituted dihydronaphthols from phenols. In this reaction, structure products is dominated by directing effect substituent groups on Meanwhile, one-pot alkylation/oxidative cyclization also spiro-fused 2,5-cyclohexadienones.
An size-tunable biodegradable MSNs used for site-specific drug delivery and further enhancing chemo-photodynamic immunotherapy.
A 3,4,5-trimethylphenol and Lewis acid dual-catalyzed cascade reaction of donor–acceptor (D–A) cyclopropanes via ring-opening cyclization is developed. In this reaction, a phenolic compound was used as covalent catalyst for the first time. Additionally, control experiments proved that completed catalytic cycle by accomplishing C–C bond cleavage. Using strategy, wide variety substituted naphthalenes has been synthesized from D–A in moderate to high yields under mild conditions.
A low-calcium microenvironment is essential for spermatozoa to mature in the epididymis; however, it remains unclear how dysregulation of epididymal luminal calcium associated with male infertility. Using a warfarin-induced vitamin K2 deficiency rat model, we found that vitamin-K-dependent γ-glutamyl carboxylase (GGCX) and matrix Gla protein (MGP) were extracellular signaling intercellular communication required sperm maturation. We GGCX MGP co-localized vesicular structures cells...
Open AccessCCS ChemistryRESEARCH ARTICLE5 Aug 2022CD44-Specific Targeting Nanoreactors with Glutathione Depletion for Magnifying Photodynamic Tumor Eradication Chao Shi, Xiao Zhou, Qiancheng Zhao, Zhen Zhang, He Ma, Yang Lu, Zhibin Huang, Wen Sun, Jianjun Du, Jiangli Fan and Xiaojun Peng Shi State Key Laboratory of Fine Chemicals, Dalian University Technology, 116024 , Zhou Zhao Zhang Ma Lu Huang Sun Shenzhen Research Institute, Nanshan District, 518057 Du *Corresponding author: E-mail...
This in vitro study aims to evaluate the crystal and surface microstructure of dental enamel after cold-light bleaching treatment. Twelve sound human premolars were cross-split into four specimens, namely, mesio-buccal (Group LP), disto-buccal P), mesio-lingual NP) disto-lingual L) specimens. These groups treated using standard procedure, a agent, peroxide-free agent cold-light, respectively. Before treatment, all specimens analyzed by high-resolution, micro-area X-ray diffraction scanning...