A5049056995- MicroRNA in disease regulation
- Invertebrate Immune Response Mechanisms
- Aquaculture Nutrition and Growth
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Renal cell carcinoma treatment
- RNA Research and Splicing
- Renal and related cancers
- Prostate Cancer Treatment and Research
- Cancer-related gene regulation
- Cell Adhesion Molecules Research
- Bladder and Urothelial Cancer Treatments
- Seaweed-derived Bioactive Compounds
- Prostate Cancer Diagnosis and Treatment
- Herpesvirus Infections and Treatments
- Echinoderm biology and ecology
- Neurobiology and Insect Physiology Research
- Photosynthetic Processes and Mechanisms
- Soybean genetics and cultivation
- RNA Interference and Gene Delivery
- Crustacean biology and ecology
- Cancer Cells and Metastasis
- Genetic Mapping and Diversity in Plants and Animals
- Coral and Marine Ecosystems Studies
- Polysaccharides and Plant Cell Walls
First Affiliated Hospital of Guangzhou Medical University
2025
Guangzhou Medical University
2015-2025
Qingdao Agricultural University
2021-2024
Chinese Academy of Sciences
2011-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Peking Union Medical College Hospital
2024
Northeast Institute of Geography and Agroecology
2021-2024
Shanxi University of Traditional Chinese Medicine
2024
University of South China
2024
Jiangyin People's Hospital
2015-2023
Crustacea, the subphylum of Arthropoda which dominates aquatic environment, is major importance in ecology and fisheries. Here we report genome sequence Pacific white shrimp Litopenaeus vannamei, covering ~1.66 Gb (scaffold N50 605.56 Kb) with 25,596 protein-coding genes a high proportion simple repeats (>23.93%). The expansion related to vision locomotion probably central its benthic adaptation. Frequent molting may be explained by an intensified ecdysone signal pathway through gene...
Apart from sharing common ancestry with chordates, sea cucumbers exhibit a unique morphology and exceptional regenerative capacity. Here we present the complete genome sequence of an economically important cucumber, A. japonicus, generated using Illumina PacBio platforms, to achieve assembly approximately 805 Mb (contig N50 190 Kb scaffold 486 Kb), 30,350 protein-coding genes high continuity. We used this resource explore key genetic mechanisms behind biological characters cucumbers....
Molting is one of the most important biological processes in shrimp growth and development. All undergo cyclic molting periodically to shed replace their exoskeletons. This process essential for growth, metamorphosis, reproduction shrimp. However, molecular mechanisms underlying remain poorly understood. In this study, we investigated global expression changes transcriptomes Pacific white shrimp, Litopenaeus vannamei, commonly cultured species worldwide. The transcriptome whole L. vannamei...
Rice (Oryza sativa) is an excellent model monocot with a known genome sequence for studying embryogenesis. Here we report the transcriptome profiling analysis of rice developing embryos using RNA-Seq as attempt to gain insight into molecular and cellular events associated generated 17,755,890 reads aligned 27,190 genes, which provided abundant data A total 23,971, 23,732, 23,592 genes were identified from at three developmental stages (3–5, 7, 14 DAP), while between allowed identification...
Simple sequence repeats (SSRs) are rare (approximately 1%) in most genomes and generally considered to have no function. However, penaeid shrimp a high proportion of SSRs (>23%), raising the question whether these play important functional evolutionary roles SSR-rich species. Here, we show that drive genome plasticity adaptive evolution two species, Fenneropenaeus chinensis Litopenaeus vannamei. Assembly comparison species at chromosome-level revealed transposable elements serve as carriers...
Early detection of lung function impairment is crucial. However, the sensitivity spirometry in detecting early deterioration limited. In this study, lungs 3180 healthy participants scheduled for annual health check were screened. Electrical impedance tomography measurements conducted 130 with normal concept establishment phase and 105 validation phase. A follow-up CT examination was suggested abnormal regional time constant or tobacco consumption ≥10 pack-years. Using as reference,...
Crustacea, particularly Decapoda, contains many economically important species, such as shrimps and crabs. Crustaceans exhibit enormous (nearly 500-fold) variability in genome size. However, limited resources are available for investigating these species. Exopalaemoncarinicauda Holthuis, an economical caridean shrimp, is a potential ideal experimental animal research on crustaceans. In this study, we performed low-coverage sequencing de novo assembly of the E. carinicauda genome. The covers...
Exoskeleton construction is an important issue in shrimp. To better understand the molecular mechanism of exoskeleton formation, development and reconstruction, transcriptome entire developmental process Litopenaeus vannamei, including nine early stages eight adult-moulting stages, was sequenced analysed using Illumina RNA-seq technology. A total 117,539 unigenes were obtained, with 41.2% predicting full-length coding sequence. Gene Ontology, Clusters Orthologous Group (COG), Kyoto...
Aquaporins (AQPs) are known to be important in cancer progression. The present study used a cDNA microarray demonstrate that AQP3, member of the AQP family, was overexpressed prostate cells. In order determine role AQP3 cancer, expression silenced by transfection with small interfering RNA, following which wound healing and invasion assays were conducted DU‑145 PC‑3 Notably, results showed silencing suppressed cell motility invasion. possible mechanisms underlying AQP3‑enhanced cells also...
Many echinoderms are regenerative species that exhibit exceptional capacity, and sea cucumber is a representative organism could regenerate the whole intestine after evisceration. There many signaling pathways participate in regeneration process, but it not clear which essential for intestinal regeneration. In this study, we performed genome-wide comprehensive analyses on these regeneration-related pathways, found Wnt pathway was one of most conservative among species. Additionally, only...
Searching for natural products with anti-tumor activity is an important aspect of cancer research. Seaweed polysaccharides from brown seaweed have shown promising activity; however, their structure, composition, and biological vary considerably, depending on many factors. In this study, 16 polysaccharide fractions were extracted purified three large species (Sargassum horneri, Scytosiphon lomentaria, Undaria pinnatifida). The chemical composition analysis revealed that the varying molecular...
Background: Despite advances in clinical therapies and technologies, the prognosis for patients with gastric cancer is still poor. The aim of this study to investigate new predictive markers cancer. Methods: In study, we evaluated expression pattern PIK3CA 107 specimens their adjacent nontumorous tissues. siRNA was synthesized transfected into cell lines. Colony formation MTT assays were employed analyze proliferation. examined by using immunohistochemical analysis Western blot assay....
Structural maintenance of chromosome 1 alpha (SMC1A) gene has been reported to be related tumor development in some types human cancers. However, the misregulation SMC1A and its functions castration-resistant prostate cancer (CRPC) have not well understood. In present study, we found that was elevated androgen-independent PCa cell lines PC-3 DU-145 compared androgen sensitive LNCap 22RV1 cells by qPCR western blot assay. Knockdown inhibited growth, colony formation migration abilities DU145...