A5100694992- Bladder and Urothelial Cancer Treatments
- Renal cell carcinoma treatment
- Prostate Cancer Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Prostate Cancer Treatment and Research
- Intracerebral and Subarachnoid Hemorrhage Research
- Intracranial Aneurysms: Treatment and Complications
- Urinary and Genital Oncology Studies
- Genetic Associations and Epidemiology
- RNA modifications and cancer
- Radiomics and Machine Learning in Medical Imaging
- Cancer-related gene regulation
- Vascular Malformations Diagnosis and Treatment
- Moyamoya disease diagnosis and treatment
- Lipoproteins and Cardiovascular Health
- Renal and related cancers
- Ferroptosis and cancer prognosis
- Urological Disorders and Treatments
- Neurological Disease Mechanisms and Treatments
- Organ Donation and Transplantation
- Adrenal and Paraganglionic Tumors
- Urologic and reproductive health conditions
- Drug Transport and Resistance Mechanisms
- Probiotics and Fermented Foods
- Neuroinflammation and Neurodegeneration Mechanisms
Shanghai University
2025
Peking University
2014-2025
Ningbo First Hospital
2015-2025
Peking University Third Hospital
2014-2025
Ningbo University
2013-2025
Minda Hospital
2024
Affiliated Hospital of Guizhou Medical University
2016-2024
Zhejiang University
2015-2024
Yue Bei People's Hospital
2024
Shantou University Medical College
2024
Puerarin was shown to exert anti-oxidative and anti-ferroptosis effects in multiple diseases. The goal of this study explore the neuroprotective effect puerarin on early brain injury (EBI) after subarachnoid hemorrhage (SAH) rats. A total 177 adult male Sprague Dawley rats were used. SAH included via endovascular perforation. Intranasal or intracerebroventricular dorsomorphin (AMPK inhibitor) SR18292 (PGC1α administered. protein levels pAMPK, PGC1α, Nrf2, 4HNE, HO1, MDA, ACSL4, GSSG, iron...
We aimed to determine the incidence and disability-adjusted life-years (DALYs) of neurological disorders worldwide from 1990 2019.We obtained age-standardised DALY rates in 204 countries territories 2019 Global Burden Disease (GBD) database. determined trends stratified by age, sex, region, country, Social Development Index (SDI) risk factors contributing DALYs associated with these disorders.The largest increases 1990-2019 occurred four regions (East Asia: estimated annual percentage change...
Purpose. To identify potential biomarkers and/or therapeutic targets for bladder cancer we characterized and analysed the composition of urinary microbiota from non-cancer patients.Methodology. In this study, collected urine samples 29 patients 26 patients. avoid contamination impact antibiotics, specimens were in a clean manner prior to antibiotic administration. Using amplicon-based next-generation sequencing approach, determinant bacteria estimated between-group comparison. The results...
The Ca2+-ATPase inhibitors, thapsigargin and cyclopiazonic acid, depleted intracellular Ca2+ stores, induced large increases in concentration, caused apoptosis S49 cells. Removal of extracellular augmented due to thapsigargin, indicating that depletion from stores is responsible for with this agent. Overexpression the suppressor, Bcl-2, inhibited but did not affect thapsigargin-induced signaling. Dexamethasone apoptosis, diminished size endoplasmic reticulum pool, a small elevation Ca2+....
The rate-distortion optimization (RDO) framework for video coding achieves a tradeoff between bit-rate and quality. However, objective distortion metrics such as mean squared error traditionally used in this are poorly correlated with perceptual We address issue by proposing an approach that incorporates the structural similarity index quality metric into framework. In particular, we develop predictive Lagrange multiplier estimation method to resolve chicken egg dilemma of perceptual-based...
PLA2G7 gene product is a secreted enzyme whose activity associated with coronary heart disease (CHD). The goal of our study to investigate the contribution promoter DNA methylation risk CHD. Using bisulphite pyrosequencing technology, was measured among 36 CHD cases and well-matched controls. Our results indicated that there significant association between (adjusted P = 0.025). Significant gender-specific correlation observed age (males: adjusted r −0.365, 0.037; females: 0.373, 0.035). A...
Background and Purpose: Intracerebral hemorrhage (ICH) is a devastating subtype of stroke with high mortality disability. Inflammatory response promotes secondary brain injury after ICH. TREM (triggering receptor expressed on myeloid cells)-1 key regulator inflammation. The aim this study was to evaluate the role TREM-1 in neuroinflammatory ICH mice. Methods: CD1 mice (n=275) were used study. Mice subjected by autologous blood injection. knockout CRISPR administered intracerebroventricularly...
Colorectal cancer (CRC) is one of the most common digestive malignancies in world. EDNRB a new candidate tumor suppressor gene which often down-regulated or even silenced by promoter hypermethylation various human cancers. However, function CRC remains unknown. In this study, we examined expression and DNA methylation tissues. A total 42 paired adjacent normal tissue samples were used to determine mRNA levels status qRT-PCR methylation-specific PCR (MSP), respectively. Our study showed that...
Abstract Although the role of N6‐Methyladenosine (m6A) methylation factors has been established in multiple cancer types, its involvement glioblastoma multiforme (GBM) remains limited. This study aims to explore m6A regulators GBM and examine their association with tumor immune microenvironment (TIME). A comprehensive set 24 candidate RNA was procured. Consensus clustering performed based on these identify distinct clusters. PD‐L1 PD‐1 levels, cell infiltration, scores were evaluated between...
To propose the bladder mucosal smoothness (BMS) grade and validate a predictive model including MRI parameters preoperatively that can evaluate early recovery of urinary continence (UC) after laparoscopic radical prostatectomy (LRP). A retrospective analysis was conducted on 203 patients (83 experienced UI at three-month follow-up) who underwent LRP in our medical center were diagnosed with prostate cancer (PCa) from June 2016 to March 2020. Patients' clinicopathological data collected....
Abstract Inflammation is a crucial factor in intracerebral hemorrhage (ICH) pathophysiology, but specific inflammatory biomarkers ICH patients remain unclear. This study aimed to identify novel circulating for improved prediction and diagnosis. We profiled expression levels of 92 cardiovascular disease related proteins plasma from 26 matched controls using Olink technology. Differentially expressed were validated ELISA RT‐qPCR second cohort. Receiver operating characteristic (ROC) curves...
The objective of this study was to evaluate the causal link between dietary habits and Alzheimer's disease (AD), utilizing a two-sample Mendelian randomization approach.
Strokes include both ischemic stroke, which is mediated by a blockade or reduction in the blood supply to brain, and hemorrhagic comprises intracerebral hemorrhage subarachnoid characterized bleeding within brain. Stroke lifethreatening cerebrovascular condition intricate pathophysiological mechanisms, including oxidative stress, inflammation, mitochondrial dysfunction, neuronal injury. Critical transcription factors, such as nuclear factor erythroid 2-related 2 kappa B, play central roles...
Intracranial aneurysm (IA) is a common cerebrovascular disease in which sacral aneurysms occurring the Wills ring region can lead to devastating subarachnoid hemorrhage. Despite advances research, underlying mechanisms of IA formation and rupture remain incompletely understood, hindering early diagnosis effective treatment. This review comprehensively summarizes current landscape biomarkers, encompassing genetic markers, DNA, RNA, inflammatory molecules, oxidative stress proteins,...
The goal of our study is to investigate the contribution promoter DNA methylation α-adducin (ADD1) gene risk essential hypertension (EH). Using bisulphite pyrosequencing technology, levels five CpG dinucleotides on ADD1 were measured among 33 EH cases and 28 healthy controls. Significantly higher observed in females than males (CpG1: P = 0.016; CpG2-5: 0.021). A breakdown analysis by gender showed that lower CpG1 was associated with an increased (adjusted 0.042). much more significant...