A5101949242- Acute Lymphoblastic Leukemia research
- Acute Myeloid Leukemia Research
- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Neuroinflammation and Neurodegeneration Mechanisms
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Endoplasmic Reticulum Stress and Disease
- Immune cells in cancer
- Mitochondrial Function and Pathology
- S100 Proteins and Annexins
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Kruppel-like factors research
- Metabolomics and Mass Spectrometry Studies
- Neonatal Respiratory Health Research
- Antibiotic Use and Resistance
- Genetics and Neurodevelopmental Disorders
- Gut microbiota and health
- RNA Interference and Gene Delivery
- Signaling Pathways in Disease
- Cancer, Hypoxia, and Metabolism
- Chronic Myeloid Leukemia Treatments
- Neuroendocrine regulation and behavior
- Virtual Reality Applications and Impacts
- ATP Synthase and ATPases Research
Ningbo First Hospital
2025
Ningbo University
2025
Xi'an Jiaotong University
2020-2025
Jilin Province Development and Reform Commission
2025
Sun Yat-sen University Cancer Center
2022-2024
Peking University People's Hospital
2021-2024
Peking University
2021-2024
Sun Yat-sen University
2022-2024
Institute of Psychology, Chinese Academy of Sciences
2023-2024
Changchun University of Chinese Medicine
2021-2024
Chronic unpredictable mild stress (CUMS) can not only lead to depression-like behavior but also change the composition of gut microbiome. Regulating microbiome have an antidepressant effect, mechanism by which it improves depressive symptoms is clear. Short-chain fatty acids (SCFAs) are small molecular compounds produced fermentation non-digestible carbohydrates. SFCAs ubiquitous in intestinal endocrine and immune cells, making them important mediators microbiome-regulated body functions....
Innate immune cells play important roles in tissue injury and repair following acute myocardial infarction (MI). Although reprogramming of macrophage metabolism has been observed during inflammation resolution phases, the mechanistic link to phenotype is not fully understood. In this study, we found that myeloid-specific deletion (mKO) mitochondrial complex I protein, encoded by Ndufs4, reproduced proinflammatory metabolic profile macrophages exaggerated response LPS. Moreover, mKO mice...
The implementation of targeted therapies for acute myeloid leukemia (AML) has been challenging. Fat mass and obesity associated protein (FTO), an mRNA N
The objective of this study was to evaluate the causal link between dietary habits and Alzheimer's disease (AD), utilizing a two-sample Mendelian randomization approach.
In hypertrophied and failing hearts, fuel metabolism is reprogrammed to increase glucose metabolism, especially glycolysis. This metabolic shift favors biosynthetic function at the expense of ATP production. Mechanisms responsible for switch are poorly understood. We found that inhibitory factor 1 mitochondrial FoF1-ATP synthase (ATPIF1), a protein known inhibit hydrolysis by reverse during ischemia, was significantly upregulated in pathological cardiac hypertrophy induced pressure overload,...
The past one and a half decades have witnessed the tremendous progress of two-dimensional (2D) crystals, including graphene, transition-metal dichalcogenides, black phosphorus, MXenes, hexagonal boron nitride, etc., in variety fields. key to their success is unique structural, electrical, mechanical optical properties. Herein, this paper gives comprehensive summary on recent advances 2D materials for optoelectronic approaches with emphasis morphology structure, properties, synthesis methods,...
Abstract Differential diagnosis of pulmonary nodules detected by computed tomography (CT) remains a challenge in clinical practice. Here, we characterize the global metabolomes 480 serum samples including healthy controls, benign nodules, and stage I lung adenocarcinoma. The adenocarcinoma demonstrates distinct metabolomic signature, whereas controls share major similarities profiles. A panel 27 metabolites is identified discovery cohort ( n = 306) to distinguish between malignant nodules....
Exposure to a harsh environment in early life increases the risk of post-traumatic stress disorder (PTSD) an individual. Brain derived neurotrophic factor (BDNF) plays important role neurodevelopment developmental stages. Both chronic and traumatic stresses induce decrease level BDNF reduce neural plasticity, which is linked pathogenesis PTSD. Also, studies have shown that alters epigenetic marker H3K9me2, can bind promoter region Bdnf gene protein level. However, long-term effects during...
Palmitic acid (PA) is known to cause cardiomyocyte dysfunction. Cardiac hypertrophy one of the important pathological features PA-induced lipotoxicity, but mechanism by which PA induces still unclear. Therefore, our study was test whether necroptosis, a receptor interacting protein kinase 1 and 3 (RIPK1 RIPK3-) dependent programmed necrosis, involved in hypertrophy. We used PA-treated primary neonatal rat cardiac myocytes (NCMs) or H9c2 cells lipotoxicity. Our results demonstrated that...
Background: Pakistan is classified as a high-burden country for tuberculosis, and the prescription of antibiotics fluoroquinolones complicates detection treatment disease. The existing literature primarily relies on knowledge questionnaires analyses, which focus healthcare providers’ rather than their actual clinical practices. Therefore, this study aimed to evaluate quality tuberculosis care using standardized patients. Materials Methods: We conducted cross-sectional study, recruiting...
Objectives: The objective of this study is to quantify healthcare resource utilization, economic burden, and the multi-level medical security system for Spinal Muscular Atrophy (SMA) patients in Shaanxi Province, China, from a societal perspective using survey. Methods: This observational employed an online survey with retrospective cross-sectional design China. examined various aspects SMA, including direct indirect burdens, co-payment mechanisms within system. Results: Following inclusion...
Strokes include both ischemic stroke, which is mediated by a blockade or reduction in the blood supply to brain, and hemorrhagic comprises intracerebral hemorrhage subarachnoid characterized bleeding within brain. Stroke lifethreatening cerebrovascular condition intricate pathophysiological mechanisms, including oxidative stress, inflammation, mitochondrial dysfunction, neuronal injury. Critical transcription factors, such as nuclear factor erythroid 2-related 2 kappa B, play central roles...
Augmented Reality (AR)-assisted exercises for the enhancement of finger functions have been developed many years and proven to be effective. Most applications tracked motion upper-extremity using handheld trackers, which are not convenient put on take off. Bare-hand tracking algorithms utilized address this limitation; however, only few AR-assisted healthcare approaches designed train skills bare-hand tracking, even fewer detect Range Motion (ROM) fingers with low-cost devices. This paper...
Cardiac hypertrophy is a crucial predictor of heart failure and regulated by microRNAs. MicroRNA-124 (miR-124) regarded as prognostic indicator for outcomes after cardiac arrest. However, whether miR-124 participates in remains unclear. Therefore, our study aimed to determine the role angiotensin II(AngII)-induced myocardial possible mechanism. Primary cultured rat neonatal cardiomyocytes(NCMs) were transfected with mimics or inhibitor, followed AngII stimulation. Quantitative RT-PCR,...
Krüppel-like Factor 4 (KLF4), a target gene of miR-145, can negatively regulate lung fibrosis. However, the potential role KLF4 and miR-145 in hepatic stellate cells (HSCs) activation or fibrosis keeps unclear. This study aims to characterize activated HSCs liver cirrhotic, underlying molecular basis. was significantly up-regulated, while dramatically down-regulated during rat primary TGF-βtreated HSCs. Furthermore, mimics induced inhibition reduced α-SMA COL-I expression Additionally, mRNA...