A5087382327- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Crystallography and molecular interactions
- Luminescence and Fluorescent Materials
- Asymmetric Synthesis and Catalysis
- Catalytic C–H Functionalization Methods
- Synthetic Organic Chemistry Methods
- Sulfur-Based Synthesis Techniques
- Fluorine in Organic Chemistry
- Asymmetric Hydrogenation and Catalysis
- Carbon dioxide utilization in catalysis
- Organic Light-Emitting Diodes Research
- Silicon and Solar Cell Technologies
- Synthesis and Catalytic Reactions
- Advanced Fluorescence Microscopy Techniques
- Integrated Circuits and Semiconductor Failure Analysis
- Chemical Synthesis and Analysis
- Catalytic Cross-Coupling Reactions
- Organoboron and organosilicon chemistry
- Photochemistry and Electron Transfer Studies
- Molecular Sensors and Ion Detection
- Supramolecular Chemistry and Complexes
- Organometallic Compounds Synthesis and Characterization
- Synthesis and Reactivity of Heterocycles
- Perovskite Materials and Applications
Agency for Science, Technology and Research
2023-2025
Institute for Sustainability
2024
McGill University
2013-2024
Institute of Materials Research and Engineering
2023-2024
Singapore University of Technology and Design
2018-2023
Xinjiang University
2023
Nanyang Technological University
2008-2021
Minjiang University
2021
Centre in Green Chemistry and Catalysis
2014-2020
King Abdullah University of Science and Technology
2012-2019
We provide a brief overview of recent advances in the use mechanochemical techniques for synthesis organic molecules and materials, highlighting selected examples transformations mechanistic studies, especially those that illustrate chemical reactions or syntheses molecular targets have remained elusive to conventional solution techniques.
A series of copper(I) trifluoromethyl thiolate complexes have been synthesized from the reaction CuF2 with Me3SiCF3 and S8 (see scheme; Cu red, F green, N blue, S yellow). These air-stable serve as reagents for efficient conversion a wide range aryl halides into corresponding thioethers in excellent yields. As service to our authors readers, this journal provides supporting information supplied by authors. Such materials are peer reviewed may be re-organized online delivery, but not...
Stable open-shell polycyclic aromatic hydrocarbons (PAHs) are of fundamental interest due to their unique electronic, optical, and magnetic properties promising applications in materials sciences. Chichibabin's hydrocarbon as a classical PAH has been investigated for long time. However, most the studies complicated by inherent high reactivity. In this work, two new stable benzannulated 1-CS 2-OS were prepared, electronic structure geometry ground state studied various experiments...
Abstract Inhibition of TICT can significantly increase the brightness fluorescent materials. Accurate prediction is thus critical for quantitative design high‐performance fluorophores and AIEgens. 14 types popular organic were modeled with time‐dependent density functional theory (TD‐DFT). A reliable generalizable computational approach modeling formations was established. To demonstrate power our approach, we quantitatively designed a boron dipyrromethene (BODIPY)‐based AIEgen which...
Heavy-atom-based photosensitizers usually exhibit shortened triplet-state lifetimes, which is not ideal for hypoxic tumor photodynamic therapy. Although several heavy-atom-free possess long the clinical applicability limited by their short excitation wavelengths, poor photon capture abilities, and intrinsically hydrophobic structures. Herein we developed a novel NIR photosensitizer design strategy introducing sterically bulky electron-rich moieties at meso position of pentamethine cyanine...
Imaging amyloid-beta (Aβ) aggregation is critical for understanding the pathology and aiding pre-symptomatic intervention of Alzheimer's disease (AD). Amyloid consists multiple phases with increasing viscosities demands probes broad dynamic ranges gradient sensitivities continuous monitoring. Yet, existing designed based on twisted intramolecular charge transfer (TICT) mechanism mainly focused donor engineering, limiting and/or these fluorophores to a narrow window. Herein, using quantum...
6 in 1: The highly enantioselective title reaction is mediated by a bifunctional catalyst and leads to E-configured vinylogous aldol products (see scheme). These are used as common intermediates the synthesis of six biologically active 3-hydroxy-2-oxindole derivatives (e.g., CPC-1). Computational studies indicated that observed stereoselectivity result favorable secondary π–π* H-bonding interactions transition state. As service our authors readers, this journal provides supporting...
We describe the development of a mechanochemical approach for Ru-catalyzed olefin metathesis, including cross-metathesis and ring-closing metathesis. The method uses commercially available catalysts to achieve high-yielding, rapid, room-temperature metathesis solid or liquid olefins on multigram scale using either no only catalytic amount liquid.
The strength of the weak: An L-tert-leucine-derived amine–thiourea catalyst (see scheme, green box) promotes asymmetric vinylogous conjugate addition reaction between γ-aryl- and alkyl-substituted butenolides with butenamides enoates shown. Computational studies show preference for observed stereochemistry is a result favourable weak non-bonding interactions, which stabilize transition state.
We demonstrate the first application of mechanochemistry to conduct synthesis sulfonyl-(thio)ureas, including known anti-diabetic drugs tolbutamide, chlorpropamide and glibenclamide, in good excellent isolated yields by either stoichiometric base-assisted or copper-catalysed coupling sulfonamides iso(thio)cyanates.
Bimolecular nucleophilic substitution (SN2) plays a central role in organic chemistry. In the conventionally accepted mechanism, nucleophile displaces carbon-bound leaving group X, often halogen, by attacking carbon face opposite C-X bond. A less common variant, halogenophilic SN2X reaction, involves initial attack of X from front and as such is sensitive to backside steric hindrance. Herein, we report an enantioconvergent reaction activated tertiary bromides thiocarboxylates or azides that,...
Abstract Reported herein is the mechanochemical synthesis of sulfonyl guanidines, a family molecules which are relevant as pharmaceuticals and herbicides, by direct coupling sulfonamides aromatic or aliphatic carbodiimides. Attempts to conduct in solution have either failed given very low conversions, thus demonstrating mechanochemistry necessary component for discovery this synthetic strategy.
Mechanochemistry is a green, solid-state, re-emerging synthetic technique that can rapidly form complex molecules and materials without exogenous heat or solvent(s). Herein, we report the application of solvent-free mechanochemical ball milling for synthesis metal halide perovskites, to overcome problems with solution-based syntheses. We prepared phase-pure, air-sensitive CsSnX3 (X = I, Br, Cl) its mixed perovskites by mechanochemistry first time reactions between cesium tin(II) halides....
Although super-resolution imaging offers an opportunity to visualize cellular structures and organelles at the nanoscale level, heterogeneity unpredictability still pose a significant challenge in dynamic of live cells. It is thus vital develop better-performing more photostable probes for long-term imaging. Herein, we report probe, LD-FG, lipid droplet (LD) dynamics using structured illumination microscopy (SIM). LD-FG allows wash-free LDs, owing hydrogen-bond sensitive fluorogenic...
Achieving wide-range tunable emission colors, especially in the solid state of single-fluorophore materials, remains a significant challenge. Herein, we report molecular design strategy that affords excitation-dependent emissions spanning over ≈230 nm crystalline states. Under donor-π-acceptor configuration, judiciously choose rotatable acceptor fragment, o-carborane, to enrich conformational diversities and generate conformation-dependent multicolor emissions. We further show this platform...
ADVERTISEMENT RETURN TO ISSUEPREVViewpointNEXTThe Role of Fugitive Hydrogen Emissions in Selecting CarriersIndranil DuttaIndranil DuttaKAUST Catalysis Center and Division Physical Science Engineering, King Abdullah University Technology, Thuwal 23955-6900, Saudi ArabiaMore by Indranil Duttahttps://orcid.org/0000-0003-0845-9193, Rajesh Kumar ParsapurRajesh ParsapurKAUST Parsapurhttps://orcid.org/0000-0002-0042-8942, Sudipta ChatterjeeSudipta ChatterjeeKAUST ArabiaDepartment Chemistry, Birla...
Eine Reihe von Kupfer(I)-Trifluormethylthiolat-Komplexen wurde durch Reaktion CuF2 mit Me3SiCF3 und S8 synthetisiert (siehe Schema; Cu rot, F grün, N blau, S gelb). Diese luftstabilen Reagentien wandeln vielfältige Arylhalogenide ausgezeichneten Ausbeuten in die entsprechenden Aryltrifluormethylthioether um. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed may be re-organized for online delivery,...
Abstract Noble metals are valued, critical elements whose chemical activation or recycling is challenging, and traditionally requires high temperatures, strong acids bases, aggressive complexation agents. By using elementary palladium gold, demonstrated here the use of mechanochemistry for noble‐metal by mild, clean, solvent‐free, room‐temperature chemistry. The process leads to direct, efficient, one‐pot conversion metals, including spent catalysts, into either simple water‐soluble salts...
Highly enantioselective allylic alkynylation of racemic bromides under biphasic condition is furnished in this report. This approach employs functionalized terminal alkynes as pro-nucleophiles and provides 6- 7-membered cyclic 1,4-enynes with high yields excellent enantioselectivities (up to 96% ee) mild conditions. Enantioretentive derivatizations highlight the synthetic utility transformation. Cold-spray ionization mass spectrometry (CSI-MS) X-ray crystallography were used identify some...
Abstract Herein, we reported a simple, fast, and quantitative theoretical descriptor Δ G C‐O that allows accurate predictions of wide range spontaneously blinking rhodamines. denotes the Gibbs free energy differences between closed open forms rhodamines has good linear relationship with experimental p K cycl values. This correlation affords an effective guide for designs eliminates trial‐and‐error. We have validated predictive power via development two different colors enhanced brightness....
Sugar-based benzothiazoles are a new class of molecules promising for many biological applications. Here, we have synthesized wide range sugar-based from readily accessible glycosyl thioureas by chemoselective, palladium-catalyzed C–S coupling reactions. Corroborated theoretical calculations, mechanistic investigation indicates that the coordination to palladium pivaloyl carbonyl group and presence intramolecular hydrogen bonding play important roles in efficiency chemoselectivity reaction....