A5078590715- Nanoplatforms for cancer theranostics
- Luminescence and Fluorescent Materials
- Advanced biosensing and bioanalysis techniques
- Advanced Nanomaterials in Catalysis
- Click Chemistry and Applications
- bioluminescence and chemiluminescence research
- Luminescence Properties of Advanced Materials
- Nanoparticle-Based Drug Delivery
- Photoreceptor and optogenetics research
- Photodynamic Therapy Research Studies
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Photoacoustic and Ultrasonic Imaging
- Supramolecular Self-Assembly in Materials
- Antibiotic Resistance in Bacteria
- Biosensors and Analytical Detection
- Molecular Sensors and Ion Detection
- Metal-Organic Frameworks: Synthesis and Applications
- RNA Interference and Gene Delivery
- Antimicrobial Peptides and Activities
- Metal complexes synthesis and properties
- Nanocluster Synthesis and Applications
- Extracellular vesicles in disease
- Chemical Synthesis and Analysis
- Gold and Silver Nanoparticles Synthesis and Applications
Nanyang Technological University
2016-2025
Agency for Science, Technology and Research
2016-2018
Institute of Materials Research and Engineering
2016-2018
Fuzhou University
2018
Tsinghua University
2015
University of Science and Technology of China
2014
National University of Singapore
2010-2013
Xiamen University
2013
University Medical Center
2011
University Hospital and Clinics
2011
Real-time monitoring of cell apoptosis could provide valuable insights into early detection therapy efficiency and evaluation disease progression. In this work, we designed synthesized a new live-cell-permeable, fluorescent light-up probe for real-time imaging. The is comprised hydrophilic caspase-specific Asp-Glu-Val-Asp (DEVD) peptide hydrophobic tetraphenylethene (TPE) unit, typical fluorogen with aggregation-induced emission characteristics. aqueous solution, the almost nonfluorescent...
Trading up: A bioimaging system that is based on caged D-luciferin/upconversion nanoparticle conjugate has been developed. The nanoparticles upconvert near-infrared light into UV light, which triggers the photorelease of D-luciferin (see scheme) and leads to enhanced fluorescence bioluminescence signals in vitro vivo. use enables deep penetration tissue vivo with minimum cellular damage. Detailed facts importance specialist readers are published as "Supporting Information". Such documents...
The development of precision nanomedicines to direct nanostructure-based reagents into tumour-targeted areas remains a critical challenge in clinics. Chemical reaction-mediated localization response tumour environmental perturbations offers promising opportunities for rational design effective nano-theranostics. Here, we present unique microenvironment-sensitive strategy peptide-premodified upconversion nanocrystals (UCNs) within areas. Upon tumour-specific cathepsin protease reactions, the...
Antibiotic hydrogels based on a vancomycin (Van) derivative, formed by self-assembling Van-pyrene (1) in water, using the π−π interaction of pyrene moieties and hydrogen bonding Vans, promise new way to make novel biomaterials.
Abstract Multifunctional mesoporous silica nanoparticles are developed in order to deliver anticancer drugs specific cancer cells a targeted and controlled manner. The nanoparticle surface is functionalized with amino‐β‐cyclodextrin rings bridged by cleavable disulfide bonds, blocking inside the mesopores of nanoparticles. Poly(ethylene glycol) polymers, an adamantane unit at one end folate other end, immobilized onto through strong β ‐cyclodextrin/adamantane complexation. non‐cytotoxic...
Abstract Platinum‐based drugs are among the most active antitumor reagents in clinical practice; their application is limited by side effects and drug resistance. A novel personalized near‐infrared (NIR) light‐activated nanoplatform obtained combining a photoactivatable platinum(IV) prodrug caspase imaging peptide conjugated with silica‐coated upconversion‐luminescent nanoparticles (UCNPs) for remote control of platinum activation, simultaneously real‐time apoptosis induced activated...
Elaborately designed biocompatible nanoplatforms simultaneously achieving multimodal bioimaging and therapeutic functions are highly desirable for modern biomedical applications. Herein, uniform MoS2 nanoflowers with a broad size range of 80-180 nm have been synthesized through facile, controllable, scalable hydrothermal method. The strong absorbance at 808 imparts them high efficiency stability photothermal conversion. Then novel multifunctional composite MoS2@Fe3O4-ICG/Pt(IV) (labeled as...
A simple and one-step method to rapidly synthesize single crystalline ultrathin gold nanowires at room temperature within a few hours has been developed, the self-assembled demonstrated an intriguing application in surface-enhanced Raman scattering (SERS).
At present, some progress has been made in the field of cancer theranostics based on nanocatalysts (NCs), but achieving precise response to specific tumor microenvironment (TME) remains a major challenge. Herein, TME-responsive upconversion nanoparticles (UCNPs)-based smart UCNPs@Cu-Cys-GOx (UCCG) nanosystem is engineered, which combines natural enzymes and nanozymes so as amplify reactive oxygen species (ROS) generation situ for starvation/chemodynamic/immunotherapy. One biggest merits this...
The most notable role of small interfering RNA (siRNA) is in interference (RNAi) and post-transcriptional gene silencing, which leads to a surge interest RNAi for both biomedical research therapeutic applications. However, "naked" siRNA cannot cross cellular membranes freely because highly negative charges limits its utility therapy. In this work, system near-infrared (NIR) light-induced release from silica coated upconversion nanoparticles (Si-UCNPs) presented. These Si-UCNPs were...
Nanomedicine have shown success in cancer therapy, but the pharmacological actions of most nanomedicine are often nonspecific to cells because utilization therapeutic agents that induce cell apoptosis from inner organelles. We herein report development semiconducting photothermal nanoagonists can remotely and specifically initiate membrane. The organic comprise polymer nanoparticles (SPNs) capsaicin (Cap) as photothermally responsive nanocarrier agonist for activation transient receptor...
Although multifunctional upconversion imaging probes have recently attracted considerable interest in biomedical research, there are currently few methods for stabilizing these luminescent nanoprobes with oligonucleotides biological systems. Herein, a method to robustly disperse physiological buffers based on rational design and synthesis of nanoconjugates comprising hairpin-DNA-modified gold nanoparticles is presented. This approach imparts the excellent biocompatibility circumvents problem...
Tumor phototheranostics in the second near-infrared window (NIR-II, 1000–1700 nm) holds great promise due to high spatiotemporal precision, enhanced penetration depth, and therapeutic efficacy. However, current "always-on" NIR-II phototheranostic agents remain restricted by inherent nonspecificity from pseudosignal readout undesirable treatment-related side effects. To address these challenges, herein we explore an activatable biocompatible nanotheranostics that generates diagnostic effects...
Here we report the first example of catalytic metallogels, which are formed irreversibly in dimethylsulfoxide via creation cross-linked, three-dimensional coordination polymer networks by using transition-metal ions with multiple sites available for and multidentate ligands. Conformational flexibility ligands slow formation polymers apparently favor gelation. These metallogels stable water most organic solvents can catalyze oxidation benzyl alcohol to benzaldehyde their PdII moieties as...
A new class of small nonfluorescent fluorogenic substrates becomes brightly fluorescent after β-lactamase hydrolysis with up to 153-fold enhancement in the fluorescence intensity. Less than 500 fM cell lysates can be readily detected, and expression living cells imaged a red derivative. These should find uses clinical diagnostics facilitate applications as biosensor.
Abstract An NIR‐responsive mesoporous silica coated upconverting nanoparticle (UCNP) conjugate is developed for controllable drug delivery and fluorescence imaging in living cells. In this work, antitumor doxorubicin (Dox) molecules are encapsulated within cross‐linked photocaged UCNPs. Upon 980 nm light irradiation, Dox could be selectively released through the photocleavage of o ‐nitrobenzyl (NB) caged linker by converted UV emission from This NIR light‐responsive demonstrates high...
Fe(3)O(4) nanoprisms, synthesized by a solvothermal process, exhibited crystal plane dependent electrochemical activities, which opens an approach to nanoscale materials with controlled properties.
Here, a set of novel and personalized nanocarriers are presented for controlled nucleus‐targeted antitumor drug delivery real‐time imaging intracellular molecule trafficking by integrating an enzyme activatable cell penetrating peptide (CPP) with mesoporous silica coated quantum dots nanoparticles. Upon loading drug, doxorubicin (DOX) further exposure to proteases in tumor environment, the enzymatic cleavage sequence activates oligocationic TAT residues on QDs@mSiO2 surface direct DOX into...