A5084122819- Nanoplatforms for cancer theranostics
- Luminescence and Fluorescent Materials
- Nanoparticle-Based Drug Delivery
- bioluminescence and chemiluminescence research
- Luminescence Properties of Advanced Materials
- Photoreceptor and optogenetics research
- RNA Interference and Gene Delivery
- Photoacoustic and Ultrasonic Imaging
- Advanced biosensing and bioanalysis techniques
- Graphene and Nanomaterials Applications
- Nanocluster Synthesis and Applications
- Carbon and Quantum Dots Applications
- Nicotinic Acetylcholine Receptors Study
- Quantum Dots Synthesis And Properties
- Gold and Silver Nanoparticles Synthesis and Applications
- Botulinum Toxin and Related Neurological Disorders
- Extracellular vesicles in disease
- Neuroscience and Neural Engineering
- Advanced Nanomaterials in Catalysis
- Nerve injury and regeneration
- Supramolecular Self-Assembly in Materials
- Chemokine receptors and signaling
- Respiratory viral infections research
- Biosensors and Analytical Detection
- Lanthanide and Transition Metal Complexes
Shanghai Jiao Tong University
2023-2024
University of California, San Diego
2020-2023
Nanyang Technological University
2016-2019
Agency for Science, Technology and Research
2018
Institute of Materials Research and Engineering
2018
Jilin University
2012-2013
Carbon dots (CDs) are remarkable nanocarriers due to their promising optical and biocompatible capabilities. However, practical applicability in cancer therapeutics is limited by insensitive surface properties complicated tumor microenvironment vivo. Herein, a extracellular microenvironment-responsive drug nanocarrier based on cisplatin(IV) prodrug-loaded charge-convertible CDs (CDs–Pt(IV)@PEG-(PAH/DMMA)) was developed for imaging-guided delivery. An anionic polymer with dimethylmaleic acid...
The development of precision nanomedicines to direct nanostructure-based reagents into tumour-targeted areas remains a critical challenge in clinics. Chemical reaction-mediated localization response tumour environmental perturbations offers promising opportunities for rational design effective nano-theranostics. Here, we present unique microenvironment-sensitive strategy peptide-premodified upconversion nanocrystals (UCNs) within areas. Upon tumour-specific cathepsin protease reactions, the...
Nanomedicine have shown success in cancer therapy, but the pharmacological actions of most nanomedicine are often nonspecific to cells because utilization therapeutic agents that induce cell apoptosis from inner organelles. We herein report development semiconducting photothermal nanoagonists can remotely and specifically initiate membrane. The organic comprise polymer nanoparticles (SPNs) capsaicin (Cap) as photothermally responsive nanocarrier agonist for activation transient receptor...
In this work, pH/redox dual-responsive carbon dots (CDs-RGD-Pt(IV)-PEG) were fabricated for tumor extracellular microenvironment triggered targeting and enhanced anticancer drug delivery. The system consists of fluorescent as imaging-guided nanocarriers, cisplatin(IV) prodrug, RGD peptide active ligand, which is covered by monomethoxypolyethylene glycol (mPEG) through pH (6.5-6.8) responsive benzoic-imine bond. nanocarriers could be tracked multicolor fluorescence dots. After the hydrolysis...
Abstract The spatiotemporal regulation of light‐gated ion channels is a powerful tool to study physiological pathways and develop personalized theranostic modalities. So far, most existing are limited by their action spectra in the ultraviolet (UV) or visible region. Simple innovative strategies for specific attachment photoswitches on cell surface without modifying genetically encoding channel structures, more importantly, that enable remote activation ion‐channel functions within...
Abstract Precise and differential profiling of the dynamic correlations pathophysiological implications multiplex biological mediators with deep penetration highly programmed precision remain critical challenges in clinics. Here we present an innovative strategy by tailoring a powerful multispectral optoacoustic tomography (MSOT) technique photon-upconverting nanoprobe (UCN) for simultaneous visualization diversely endogenous redox biomarkers excellent spatiotemporal resolution living...
Cellular binding and entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are mediated by its spike glycoprotein (S protein), which binds with not only the human angiotensin-converting enzyme (ACE2) receptor but also glycosaminoglycans such as heparin. Cell membrane-coated nanoparticles ("cellular nanosponges") mimic host cells to attract neutralize SARS-CoV-2 through natural cellular receptors, leading a broad-spectrum antiviral strategy. Herein, we show that increasing...
Near-infrared (NIR) light-mediated photodynamic therapy (PDT), especially based on lanthanide-doped upconversion nanocrystals (UCNs), have been extensively investigated as a promising strategy for effective cellular ablation owing to their unique optical properties convert NIR light excitation into multiple short-wavelength emissions. Despite the deep tissue penetration of in living systems, therapeutic efficiency is greatly restricted by insufficient oxygen supply hypoxic tumor...
With the rapid development of nanotechnology, unique rare-earth lanthanide-doped upconversion nanocrystals (UCNs), which can convert tissue-penetrable near-infrared (NIR) photonic irradiation into ultraviolet, visible, and NIR emissions, have a significant potential in bioimaging, diagnosis, therapy, as well photovoltaic systems optical data storage. Despite promising achievements made past decade, critical challenges associated with low efficiencies overheating effect induced by...
Neurotoxins attack and destruct the nervous system, which can cause serious health problems security threats. Existing detoxification approaches, such as antibodies small molecule antidotes, rely on neurotoxin's molecular structure design cues require toxin-specific development for each type of toxins. However, enormous diversity neurotoxins makes structure-based antitoxin particularly challenging inefficient. Here, we report use neuronal membrane-coated nanosponges (denoted "Neuron-NS") an...
Current drug delivery approaches for the treatment of cartilage disorders such as osteoarthritis (OA) remain inadequate to achieve sufficient penetration and retention in dense matrix. Herein, we synthesize sub-30 nm lipid-polymer hybrid nanoparticles functionalized with collagen-targeting peptides targeted cartilage. The consist a polymeric core encapsulation lipid shell modified collagen-binding peptide. By combining these design features, can penetrate deep accumulate preferentially Using...
Platinum-based chemotherapy, although it has been well proven to be effective in the battle against cancer, suffers from limited specificity, severe side effects and drug resistance. The development of new alternatives with potent anticancer improved specificity is therefore urgently needed. Recently, there are some chemotherapy reagents based on photoactive Re(i) complexes which have reported as promising improve mainly attributed spatial temporal activation process by light irradiation....
NIR photoacoustic and upconversion luminescent nanoprobe-facilitated cross-referencing manifestation of oxidative stress-induced liver pathophysiology for dynamic therapeutic response assessment.