A5011455423- DNA and Nucleic Acid Chemistry
- Advanced biosensing and bioanalysis techniques
- RNA and protein synthesis mechanisms
- RNA Interference and Gene Delivery
- Topological and Geometric Data Analysis
- Crystallization and Solubility Studies
- RNA modifications and cancer
- Computational Drug Discovery Methods
- X-ray Diffraction in Crystallography
- Cancer-related molecular mechanisms research
- Problem Solving Skills Development
- Bacteriophages and microbial interactions
- Family and Disability Support Research
- Molecular Junctions and Nanostructures
- Crystallography and molecular interactions
- Ionic liquids properties and applications
- Homotopy and Cohomology in Algebraic Topology
- Child and Adolescent Psychosocial and Emotional Development
- Aerogels and thermal insulation
- Protein Structure and Dynamics
- MicroRNA in disease regulation
- Optical Coherence Tomography Applications
- Photodynamic Therapy Research Studies
- Advanced Cellulose Research Studies
- Privacy-Preserving Technologies in Data
Nanyang Technological University
2014-2024
Central South University
2024
Fourth Hospital of Hebei Medical University
2024
Hebei Medical University
2024
University of Nebraska–Lincoln
2024
Zhejiang University-University of Edinburgh Institute
2021
Northeast Forestry University
2016
Fudan University
2012
PerSpect-based machine learning models can significantly improve prediction accuracy for protein-ligand binding affinity.
Problem-solving skills training (PSST) has a demonstrated potential to improve psychosocial well-being for parents of children with chronic health conditions (CHCs), but such evidence not been fully systematically synthesized.
Sustainable carbon aerogels with low density (≈7.8 mg cm −3 ), high porosity, resiliency, excellent hydrophobicity, and oleophilic characteristics are synthesized by employing nanofibrillated cellulose as the precursor. The as‐prepared show a remarkable capacity for absorption of variety oils organic solvents weight gains ranging from 7422 to 22356. Under extreme conditions (e.g., at severe temperatures in corrosive liquids), these still demonstrate superior performance. Furthermore, device...
Abstract In this paper, we systematically review weighted persistent homology (WPH) models and their applications in biomolecular data analysis. Essentially, the weight value, which reflects physical, chemical biological properties, can be assigned to vertices (atom centers), edges (bonds), or higher order simplexes (cluster of atoms), depending on structure, function, dynamics properties. Further, propose first localized (LWPH). Inspired by great success element specific (ESPH), do not...
Double-stranded RNA (dsRNA) structures form triplexes and RNA-protein complexes through binding to single-stranded (ssRNA) regions proteins, respectively, for diverse biological functions. Hence, targeting dsRNAs major-groove triplex formation is a promising strategy the development of chemical probes potential therapeutics. Short (e.g., 6-10 mer) chemically-modified Peptide Nucleic Acids (PNAs) have been developed that bind sequence specifically at physiological conditions. For example, PNA...
Abstract It has long been observed that trimethylamine N-oxide (TMAO) and urea demonstrate dramatically different properties in a protein folding process. Even with the enormous theoretical experimental research work on these two osmolytes, various aspects of their underlying mechanisms still remain largely elusive. In this paper, we propose to use weighted persistent homology systematically study osmolytes molecular aggregation hydrogen-bonding network from local topological perspective. We...
Due to the unique three dimensional structures of Ru complexes, strong interactions such as H-bonds between <italic>z</italic>-axial ligands and cation channels in G-quadruplexes enabled not only efficient stabilization G-quadruplexes, but excellent binding resistance against duplex DNA.
Chemically modified peptide nucleic acids (PNAs) show great promise in the recognition of RNA duplexes by major-groove PNA·RNA–RNA triplex formation. Triplex formation is favored for with a purine tract within one duplex strands, and severely destabilized if interrupted pyrimidine residues. Here, we report synthesis PNA monomer incorporated an artificial nucleobase S, followed binding studies series S-modified PNAs. Our data suggest that S residue into short 8-mer dsRNA-binding PNAs (dbPNAs)...
RNAs are emerging as important biomarkers and therapeutic targets. The strategy of directly targeting double-stranded RNA (dsRNA) by triplex-formation is relatively underexplored mainly due to the weak binding at physiological conditions for traditional triplex-forming oligonucleotides (TFOs). Compared DNA RNA, peptide nucleic acids (PNAs) chemically stable have a neutral peptide-like backbone, thus, they show significantly enhanced natural acids. We successfully developed...
ABSTRACT Aims To explore the mediating roles of family resources (at individual [parental self‐efficacy], [family resilience] and social level [social support]) parental problem‐solving skills in association between functioning adaptation families children with cancer. Design A cross‐sectional study. Methods This study recruited 318 parents cancer from three tertiary hospitals mainland China. Self‐report questionnaires were used to collect data on key variables, including functioning,...
Electron conductivity of duplex DNA has promising applications in fabricating based biosensors and electronic devices for biomimic solar cells. However, aqueous solution DNA-mediated electron transfer (ET) is often far from ideal these applications. We reported here that hydrated ionic liquids (IL) can propagate through 4 nm DNA, higher ET efficiency was achieved over longer distance which yielded a noncanonical negative decay parameter (γ = −0.02 Å–1). Fluorescence studies IL-D2O revealed...
Artificial intelligence (AI)-based drug design has great promise to fundamentally change the landscape of pharmaceutical industry. Even though there are progress from handcrafted feature-based machine learning models, 3D convolutional neural networks (CNNs) and graph networks, effective efficient representations that characterize structural, physical, chemical biological properties molecular structures interactions remain be a challenge. Here, we propose an equal-sized 2D image...
Background Artificial intelligence (AI) has been increasingly used in healthcare during the last decade, and recent applications oncology nursing have shown great potential improving care for patients with cancer. It is timely to comprehensively synthesize knowledge about progress of AI technologies nursing. Objective The aims this study were evaluate existing evidence applied Methods A scoping review was conducted based on methodological framework proposed by Arksey O’Malley later improved...
Fluorogenic Pt complexes were developed to track and compare the intracellular un/folding behaviors of RNA G-quadruplexes among different cell lines.
RNA secondary structures comprise double-stranded (ds) and single-stranded (ss) regions. Antisense peptide nucleic acids (asPNAs) enable the targeting of ssRNAs weakly formed dsRNAs. Nucleobase-modified dsRNA-binding PNAs (dbPNAs) allow for dsRNA targeting. A programmable RNA-structure-specific strategy is needed simultaneous recognition dsRNAs ssRNAs. Here, we report on combining dbPNAs asPNAs (designated as daPNAs) dsRNA-ssRNA junctions. Our data suggest that traditional asPNA (with a...
A general assembly approach is developed to construct hierarchically tunable helical superstructures from an achiral porphyrin-incorporated alkoxysilane. The resulting can be controlled film, rice, spindle, ribbon, fiber in morphology and nonhelical structure at a multiscale with excellent optoelectronic, electrical, thermal properties.
Abstract DNA offers a means of long‐range charge transport for biology and electric nanodevices. Here, series tetra‐stranded G‐quadruplexes were assembled within dendritic architecture to explore oxidative (hole transport) through the G‐quadruplex. Efficient was achieved over 28 Å upon UV irradiation. Over longer G‐quadruplex bridge, hole escalated higher efficiency, which resulted in yield than that optimal duplex transport, is, adenine tract. suggests G‐quadruplexes, instead an oxidation...
DNA tetrahedron as the simplest 3D nanostructure has been applied widely in biomedicine and biosensing. Herein, we design fabricate a series of circular assemblies with high purity decent yields. These nanostructures are confirmed by endonuclease digestion, gel electrophoresis atomic force microscopy. Inspired rotary protein motor, demonstrate these architectures can serve stator for motor to achieve rotation. The rotate on stators several cycles, locomotion is monitored real-time...
G-quadruplexes (GQ) folded by the oncogenic G-rich sequences are promising targets for developing anticancer therapeutic molecules. However, current drug development mainly focused on non-covalent dynamic binders to stabilize GQ structures, while covalent targeting from inorganic complexes via chelating principles, as a potent strategy was surprisingly lack of exploration. Herein, series dinuclear platinum complexes, [(Pt(Dip)Cl)2(μ-diamine)](NO3)2 (Dip: 4,7-diphenyl-1,10-phenanthroline),...
In this paper, we propose persistent spectral based machine learning (PerSpect ML) models for drug design. Persistent models, including graph, simplicial complex and hypergraph, are proposed on graph theory, theory hypergraph respectively. Different from all previous a filtration process, as in homology, is introduced to generate multiscale models. More specifically, the series of nested topological representations, i,e., graphs, complexes, hypergraphs, can be systematically generated their...
Using amino-labeled oligonucleotide probes, we established a simple, robust and low-noise method for simultaneous detection of RNA DNA by fluorescence in situ hybridization, highly useful tool to study the large pool long non-coding RNAs being identified current research. With probes either chemically or biologically synthesized, demonstrate that can be applied wide range targets at single-cell single-molecule level cellular contexts.
Charge transport (CT) through biomolecules is of high significance in the research fields biology, nanotechnology, and molecular devices. Inspired by our previous work that showed binding ionic liquid (IL) facilitated charge duplex DNA, silico simulation a useful means to understand microscopic mechanism facilitation phenomenon. Here dynamics simulations (MD) DNA water hydrated liquids were employed explore helical parameters. Principal component analysis was further applied capture subtle...