A5057679388- bioluminescence and chemiluminescence research
- Photoreceptor and optogenetics research
- Nanoplatforms for cancer theranostics
- Luminescence and Fluorescent Materials
- Nicotinic Acetylcholine Receptors Study
- Luminescence Properties of Advanced Materials
- RNA Interference and Gene Delivery
- Nanoparticle-Based Drug Delivery
- Supramolecular Self-Assembly in Materials
- Antimicrobial Resistance in Staphylococcus
- Synthesis of Tetrazole Derivatives
- Antibiotics Pharmacokinetics and Efficacy
- Molecular Sensors and Ion Detection
- Extracellular vesicles in disease
- Antibiotic Resistance in Bacteria
- Advanced biosensing and bioanalysis techniques
- 3D Printing in Biomedical Research
- Tannin, Tannase and Anticancer Activities
- Curcumin's Biomedical Applications
- Innovative Microfluidic and Catalytic Techniques Innovation
- Cancer, Hypoxia, and Metabolism
- Cancer, Stress, Anesthesia, and Immune Response
Nanyang Technological University
2017-2020
Guiyang Medical University
2018
Abstract The spatiotemporal regulation of light‐gated ion channels is a powerful tool to study physiological pathways and develop personalized theranostic modalities. So far, most existing are limited by their action spectra in the ultraviolet (UV) or visible region. Simple innovative strategies for specific attachment photoswitches on cell surface without modifying genetically encoding channel structures, more importantly, that enable remote activation ion‐channel functions within...
Near-infrared (NIR) light-mediated photodynamic therapy (PDT), especially based on lanthanide-doped upconversion nanocrystals (UCNs), have been extensively investigated as a promising strategy for effective cellular ablation owing to their unique optical properties convert NIR light excitation into multiple short-wavelength emissions. Despite the deep tissue penetration of in living systems, therapeutic efficiency is greatly restricted by insufficient oxygen supply hypoxic tumor...
With the rapid development of nanotechnology, unique rare-earth lanthanide-doped upconversion nanocrystals (UCNs), which can convert tissue-penetrable near-infrared (NIR) photonic irradiation into ultraviolet, visible, and NIR emissions, have a significant potential in bioimaging, diagnosis, therapy, as well photovoltaic systems optical data storage. Despite promising achievements made past decade, critical challenges associated with low efficiencies overheating effect induced by...
Emergence of antibiotic bacterial resistance has caused serious clinical issues worldwide due to increasingly difficult treatment. Development a specific approach for selective visualization resistant bacteria will be highly significant investigations promote timely diagnosis and treatment infections. In this article, we present an effective method that not only is able selectively recognize drug AmpC β-lactamases enzyme but, more importantly, interact with cell wall components, resulting in...
Abstract Multidrug resistance (MDR) poses a major burden to cancer treatment. As one important factor contributing MDR, overexpression of P‐glycoprotein (P‐gp) results in reduced intracellular drug accumulation. Hence, the ability effectively block efflux protein and accumulate therapeutics cells is great significance clinical practice. In this work, we successfully developed smart stimulus‐responsive short peptide‐assembled system, termed as PD/VER nanogels, which synergistically combined...
Abstract The spatiotemporal regulation of light‐gated ion channels is a powerful tool to study physiological pathways and develop personalized theranostic modalities. So far, most existing are limited by their action spectra in the ultraviolet (UV) or visible region. Simple innovative strategies for specific attachment photoswitches on cell surface without modifying genetically encoding channel structures, more importantly, that enable remote activation ion‐channel functions within...
A larger number of human diseases are related to dysregulation or loss cellular functions. Effective restoration the missing defective functions is highly desirable for fundamental research and therapeutic applications. Inspired by fantastic feature cell-derived extracellular vesicles (EVs) that can transport various bioactive molecules between cells, herein, we developed a simple efficient strategy based on EVs transferring ion channels recipient thereby conferring specific biological...
Lanthanide-doped upconversion nanocrystals (UCNs) have attracted much attention in recent years based on their promising and controllable optical properties, which allow for the absorption of near-infrared (NIR) light can subsequently convert it into multiplexed emissions that span over a broad range regions from UV to visible NIR.This article presents detailed experimental procedures high-temperature co-precipitation synthesis core-shell UCNs incorporate different lanthanide ions...
A unique lanthanide complex which responds to near-infrared (NIR) stimulation was developed for remote regulation of cellular events. This molecule can be localized specifically on the cell surface. Upon NIR stimulation, strong emission successfully modulate activities light-gated membrane channels and regulate ion flux in vivo.
Die spatiotemporale Steuerung der Aktivität …… von Membrankanälen in lebenden Systemen durch Bestrahlung mit Nah-IR-Licht (λ=808 nm) wird B. Xing, G. Liu und Mitarbeitern Zuschrift auf S. 3077 ff. beschrieben. Im Verlauf Glykan-Biosynthese werden Lanthanoid-dotierte aufwärtskonvertierende Nanokristalle (UCNs) über kupferfreie Klick-Cyclisierung an Zelloberfläche angebracht. Der Kationen-Einstrom lässt sich die steuern, membranassoziierte Aktivitäten wurden Zellen Zebrafischen manipuliert.
Lanthanide-doped upconversion nanocrystals (UCNs) have attracted much attention in recent years based on their promising and controllable optical properties, which allow for the absorption of near-infrared (NIR) light can subsequently convert it into multiplexed emissions that span over a broad range regions from UV to visible NIR. This article presents detailed experimental procedures high-temperature co-precipitation synthesis core-shell UCNs incorporate different lanthanide ions...
Objective To evaluate the effects of turmeric volatile oil (TVO) combined with cisplatin on proliferation and apoptosis a human cutaneous squamous cell carcinoma line A431, to explore their mechanisms. Methods Some cultured A431 cells at exponential growth phase were divided into several groups be treated 5, 10, 20, 40 80 mg/L TVO, as well high-glucose Dulbecco′s modified Eagle′s medium (DMEM) containing 1% dimethyl sulfoxide (DMSO, control group) , respectively. After 24-hour...