A5102960156- Aldose Reductase and Taurine
- Nanoplatforms for cancer theranostics
- Toxic Organic Pollutants Impact
- Air Quality and Health Impacts
- Climate Change and Health Impacts
- Neuroinflammation and Neurodegeneration Mechanisms
- Photodynamic Therapy Research Studies
- Nanoparticle-Based Drug Delivery
- Carcinogens and Genotoxicity Assessment
- Tryptophan and brain disorders
- Arsenic contamination and mitigation
- Prenatal Substance Exposure Effects
- Cancer therapeutics and mechanisms
- Biochemical effects in animals
- Luminescence and Fluorescent Materials
- Acupuncture Treatment Research Studies
- Per- and polyfluoroalkyl substances research
- Graphene and Nanomaterials Applications
- Phytochemistry and Biological Activities
- Electrospun Nanofibers in Biomedical Applications
- Heavy Metal Exposure and Toxicity
- RNA Research and Splicing
- Plasmonic and Surface Plasmon Research
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Receptor Mechanisms and Signaling
Tianjin Anding Hospital
2025
Nankai University
2025
Tianjin Medical University
2025
Heidelberg University
2025
Fujian Medical University
2022-2024
Wuhan University of Science and Technology
2023-2024
Xi'an Jiaotong University
2024
Second Affiliated Hospital of Fujian Medical University
2022-2024
Luoyang Institute of Science and Technology
2024
Hubei University of Chinese Medicine
2022-2023
It remains a considerable challenge to realize complete tumor suppression and avoid regrowth by rational design of photosensitizers (PSs) improve their photon utilization. In this Article, we provide molecular (Icy-NBF) based on the oxygen-content-regulated deactivation process excited states. presence overexpressed nitroreductase in hypoxic cancer cells, Icy-NBF is reduced converted into molecule with same skeleton (Icy-NH2), which PS under 808 nm light irradiation proceeds via different...
Abstract Neuronal death is known to trigger reactive microgliosis. However, little regarding the manner by which microglia are activated injured neurons and how microgliosis participates in neurodegeneration. In this study we delineate critical role of macrophage Ag complex-1 (MAC1), a member β2 integrin family, mediating promoting dopaminergic (DAergic) neurodegeneration 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model Parkinson’s disease. MAC1 deficiency greatly attenuated DAergic...
Abstract Spectrally‐selective photodetection via organic semiconductors manifesting narrowband absorption (NBA photodetection) is highly attractive for emerging applications that require ultrathin, lightweight, and low‐cost solutions. While successful over mainstream color bands, NBA photodetectors have struggled so far to meet the functional and/or performance demands at longer wavelengths, importantly in far‐red (700–750 nm), a range relevant diverse analytical biology, medical...
Catalpol, an iridoid glycoside abundant in the roots of Rehmannia glutinosa, has been previously found to prevent loss CA1 hippocampal neurons and reduce working errors gerbils after ischemia-reperfusion injury. In present study, we investigated effects catalpol on astrocytes ischemic model further characterize its neuroprotective mechanisms. Primary cultured exposed oxygen-glucose deprivation (OGD) followed by reperfusion (adding back oxygen glucose, OGD-R), were used as vitro model....
Arsenic (As) is a ubiquitous environmental contaminant. Excess As exposure considered one of the top health threats worldwide. As-induced Male reproductive toxicity causing wide concern. The goal this study to determine whether subchronic inhibits Ddx3y expression, an Y-linked gene important in spermatogenesis and sperm maturation, inhibited expression closely associated with male Adult mice were given drinking water alone or containing 1, 2, 4mg/l arsenic trioxide (As2O3) for 60 days. After...
ABSTRACT Background Clozapine exhibits significant therapeutic efficacy in schizophrenia, especially treatment‐resistant schizophrenia. However, clozapine can cause agranulocytosis, a fatal adverse effect, and the aim of this study is to explore mechanism based on network pharmacology molecular docking. Method Six two databases were used identify targets associated with respectively. The bioinformatics online platform was overlaps between drug disease targets. protein–protein interaction...
Abstract The tunable synaptic plasticity of biological sensory systems plays a pivotal role in efficient information processing and adaptation. Bio‐mimetic devices, particularly those for tactile synapses, usually lack effective gating control thus exhibit limited adaptability to external stimuli. Here, an artificial sensor is introduced that mimics the features systems. monolithic device utilizes iongel‐gated single‐walled carbon nanotube (SWCNT) network transistor with slow but reversible...
Doxorubicin (DOX) is a widely-used effective antitumor agent. However, its clinical application limited due to side effects including anti-apoptotic defense of cancer cells caused by DOX-induced autophagy and deleterious in normal tissues. Therefore, this study, new folate (FA)-decorated amphiphilic bifunctional pullulan-based copolymer (named as FPDP) was developed an efficient nano-carrier for the co-delivery DOX short hairpin RNA Beclin1, pivotal autophage-related gene, enhance anticancer...
Organophosphate flame retardants (OPFRs) are alternatives to brominated (BFRs) and have recently gained wide acceptance in various materials. For the treatment prevention of diseases, it is also important clarify relationship between OPFRs tumors, despite fact that less toxic than BFRs. This research used TCGA CTD databases for transcriptome profiling identifying OPFRs-related genes. GO KEGG analyses suggested may be closely related colorectal cancer (CRC), genes correlated with were...
Abstract Activation of the β2 adrenergic receptor (β2AR) on immune cells has been reported to possess anti‐inflammatory properties, however, pro‐inflammatory properties β2AR activation remain unclear. In this study, using rat primary mesencephalic neuron‐glia cultures, we report that salmeterol, a long‐acting agonist, selectively induces dopaminergic (DA) neurotoxicity through its ability activate microglia. Salmeterol increased production reactive oxygen species (ROS) by NADPH oxidase...
Combined treatment of drugs and therapeutic genes has emerged as a new modality anticancer therapy.