A5080811290- Testicular diseases and treatments
- Urologic and reproductive health conditions
- Sarcoma Diagnosis and Treatment
- Bladder and Urothelial Cancer Treatments
- Genital Health and Disease
- Neuroblastoma Research and Treatments
- Renal cell carcinoma treatment
- Prostate Cancer Treatment and Research
- Cancer Immunotherapy and Biomarkers
- Urological Disorders and Treatments
- Sexual Differentiation and Disorders
- Renal and related cancers
- Prostate Cancer Diagnosis and Treatment
- Multiple and Secondary Primary Cancers
- Urinary and Genital Oncology Studies
- Ovarian cancer diagnosis and treatment
- Cancer Genomics and Diagnostics
- Multiple Myeloma Research and Treatments
- Cervical Cancer and HPV Research
- Cancer Diagnosis and Treatment
- COVID-19 and healthcare impacts
- Lung Cancer Treatments and Mutations
- Colorectal and Anal Carcinomas
- Cancer therapeutics and mechanisms
- Glioma Diagnosis and Treatment
Fondazione IRCCS Istituto Nazionale dei Tumori
2015-2024
Laboratoire des Sciences de l'Ingénieur, de l'Informatique et de l'Imagerie
2020-2022
University of Birmingham
2020-2021
Institut de Virologie
2021
NIHR Birmingham Biomedical Research Centre
2021
Yorkshire Cancer Research
2021
Urology Foundation
2021
Association for Cancer Surgery
2021
AstraZeneca (Brazil)
2020
Stryker (United Kingdom)
2020
Purpose To determine the activity of pembrolizumab as neoadjuvant immunotherapy before radical cystectomy (RC) for muscle-invasive bladder carcinoma (MIBC) which standard cisplatin-based chemotherapy is poorly used. Patients and Methods In PURE-01 study, patients had a predominant urothelial histology clinical (c)T≤3bN0 stage tumor. They received three cycles 200 mg every 3 weeks RC. The primary end point in intention-to-treat population was pathologic complete response (pT0). Biomarker...
Abstract Limited information is available concerning the expression and role of microRNAs in prostate cancer. In this study, we investigated involvement miR-205 carcinogenesis. Significantly lower levels were found cancer than normal cell lines as well tumor compared with matched tissues, a particularly pronounced reduction carcinomas from patients local-regionally disseminated disease. Restoring cells resulted rearrangements consistent mesenchymal-to-epithelial transition, such...
In November 2011, the Third European Consensus Conference on Diagnosis and Treatment of Germ-Cell Cancer (GCC) was held in Berlin, Germany. This third conference followed similar meetings 2003 (Essen, Germany) 2006 (Amsterdam, The Netherlands) [Schmoll H-J, Souchon R, Krege S et al. consensus diagnosis treatment germ-cell cancer: a report Group (EGCCCG). Ann Oncol 2004; 15: 1377-1399; S, Beyer J, R second meeting group (EGCCCG): part I. Eur Urol 2008; 53: 478-496; II. 497-513]. A panel 56 60...
To assess the value of postsurgery chemotherapy in patients with disseminated nonseminomatous germ-cell tumors (NSGCTs) and viable residual disease after first-line cisplatin-based chemotherapy.The outcome 238 was reviewed. Tumor markers had normalized all before resection. A multivariate analysis survival performed on 146 patients.The 5-year progression-free (PFS) rate 64% overall (OS) 73%. Three factors were independently associated both PFS OS: complete resection (P <.001), < 10%...
Abstract Background Aberrant expression of microRNAs, small non-coding RNA molecules that post-transcriptionally repress gene expression, seems to be causatively linked the pathogenesis cancer. In this context, miR-21 was found overexpressed in different human cancers (e.g. glioblastoma, breast cancer). addition, it is thought endowed with oncogenic properties due its ability negatively modulate tumor-suppressor genes PTEN ) and cause reversion malignant phenotype when knocked- down several...
No AccessJournal of Urology1 Sep 1985Unilateral Lymphadenectomy in Intraoperative Stage I Nonseminomatous Germinal Testis Cancer Giorgio Pizzocaro, Roberto Salvioni, and Fulvio Zanoni PizzocaroGiorgio Pizzocaro More articles by this author , SalvioniRoberto Salvioni ZanoniFulvio View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)47252-1AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Bilateral retroperitoneal...
No AccessJournal of UrologyAdult Urology1 Apr 2014The Relationship between Characteristics Inguinal Lymph Nodes and Pelvic Node Involvement in Penile Squamous Cell Carcinoma: A Single Institution Experience Giovanni Lughezzani, Mario Catanzaro, Tullio Torelli, Luigi Piva, Davide Biasoni, Silvia Stagni, Alessandro Crestani, Andrea Guttilla, Daniele Raggi, Patrizia Giannatempo, Necchi, Giorgio Pizzocaro, Maurizio Colecchia, Roberto Salvioni, Nicola Nicolai LughezzaniGiovanni Lughezzani...
Objective To harness the frontline therapy in advanced penile squamous cell carcinoma (PSCC), for which chemotherapy exerts moderate activity but poor efficacy. Dacomitinib is an irreversible, pan‐epidermal growth factor receptor (HER) inhibitor. Patients and Methods In a phase 2 study (NCT01728233), patients received dacomitinib 45 mg/day, orally, continuously. Inclusion criteria were SCC histology, clinical stage N 2–3 or M 1 (Tumour‐Node‐Metastasis classification system 2009), no prior...
We assessed prognostic factors, treatments and outcomes in patients with teratoma malignant transformation, a rare occurrence among germ cell tumors.Data on diagnosed transformation between June 1981 August 2014 were collected across 5 referral centers. Chemotherapy was dichotomized as based tumor or transformation. Cox analyses done to evaluate factors of overall survival, the primary end point. Each factor evaluated univariable model. Forward stepwise selection used construct an optimal...
Teratoma with a malignant somatic component (MSC) is rare phenomenon recognized when type malignancy occurs in the context of germ cell tumor (GCT). The authors present their 29-year experience 40 patients treated from 1981 to 2009 institution. average age was 31 years. All underwent radical orchiectomy, which demonstrated GCT 19 an MSC. MSC observed other 21 cases metastatic sites, including lung (13), liver (3), pleura (1), mediastinum (7), supraclavicular lymph nodes and retroperitoneal...
Between August 1981 and December 1984, 85 consecutive patients with clinical stage I nonseminomatous germ cell tumors of the testis who were suitable for close observation entered a surveillance study after orchiectomy alone. All had unequivocally negative chest x-ray, bipedal lymph-angiography, computerized tomography abdomen pelvis, normal levels alpha-fetoprotein human chorionic gonadotropin before entering study. Patients followed closely 24 to 64 months (median 42 months) regular...
No AccessJournal of UrologyAdult urology1 Aug 2007Conservative Surgical Therapy for Leydig Cell Tumor Luca Carmignani, Renzo Colombo, Franco Gadda, Giacomo Galasso, Andrea Lania, Juan Palou, Ferran Algaba, Humberto Villavicencio, Giovanni Maria Colpi, Ottavio Decobelli, Roberto Salvioni, Giorgio Pizzocaro, Patrizio Rigatti, and Francesco Rocco CarmignaniLuca Carmignani Urology Unit, Department Medicine Surgery, University Milan, Fondazione Ospedale Maggiore Policlinico, Mangiagalli e Regina...
Forty consecutive patients with far-advanced germinal testis tumors (lymph node metastases > 10 cm, pulmonary nodules 5 extrapulmonary spread, alpha-fetoprotein 1000 ng/ml, human chorionic gonadotropin 50,000 mIU/ml) were treated five courses of cisplatin, etoposide, and bleomycin (PEB). Twenty-five underwent surgery for the removal residual masses after first three inductions. Fibrotic—necrotic tissue was resected in 11 cases, 12 had mature teratoma, cancer found 2. After combined-modality...