A5030668493- Sports injuries and prevention
- Musculoskeletal pain and rehabilitation
- Sports Performance and Training
- Shoulder Injury and Treatment
- Testicular diseases and treatments
- Muscle activation and electromyography studies
- Tendon Structure and Treatment
- Lower Extremity Biomechanics and Pathologies
- Cardiovascular and exercise physiology
- Cardiovascular Effects of Exercise
- Muscle metabolism and nutrition
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Sarcoma Diagnosis and Treatment
- Exercise and Physiological Responses
- Foot and Ankle Surgery
- Multiple Myeloma Research and Treatments
- Colorectal Cancer Treatments and Studies
- Occupational Health and Performance
- Shoulder and Clavicle Injuries
- Cancer Immunotherapy and Biomarkers
- Diabetic Foot Ulcer Assessment and Management
- Body Composition Measurement Techniques
- Neutropenia and Cancer Infections
- Colorectal and Anal Carcinomas
- Ovarian cancer diagnosis and treatment
University of Potsdam
2016-2025
Qualcomm (United Kingdom)
2022-2024
University of Exeter
2024
Hochschule Osnabrück
2023
Brandenburg University of Technology Cottbus-Senftenberg
2021-2022
Institute for Sports Medicine
2001-2022
VA New Jersey Health Care System
2022
University of Applied Sciences Potsdam
2010-2020
Universität Trier
2020
Jefferson University Hospitals
2019
<h3>Importance</h3> Surgical resection has a potential benefit for patients with metastatic adenocarcinoma of the stomach and gastroesophageal junction. <h3>Objective</h3> To evaluate outcome in limited disease who receive chemotherapy first proceed to surgical resection. <h3>Design, Setting, Participants</h3> The AIO-FLOT3 (Arbeitsgemeinschaft Internistische Onkologie–fluorouracil, leucovorin, oxaliplatin, docetaxel) trial is prospective, phase 2 252 resectable or gastric junction...
In November 2011, the Third European Consensus Conference on Diagnosis and Treatment of Germ-Cell Cancer (GCC) was held in Berlin, Germany. This third conference followed similar meetings 2003 (Essen, Germany) 2006 (Amsterdam, The Netherlands) [Schmoll H-J, Souchon R, Krege S et al. consensus diagnosis treatment germ-cell cancer: a report Group (EGCCCG). Ann Oncol 2004; 15: 1377-1399; S, Beyer J, R second meeting group (EGCCCG): part I. Eur Urol 2008; 53: 478-496; II. 497-513]. A panel 56 60...
Key points Classic motor unit (MU) recording and analysis methods do not allow the same MUs to be tracked across different experimental sessions, therefore, there is limited evidence on adjustments in MU properties following training or during progression of neuromuscular disorders. We propose a new processing method track sessions (separated by weeks) using high‐density surface electromyography. The application proposed two experiments showed that individual can identified reliably...
In order to further compare shod versus barefoot running, 35 subjects ran two bouts of 4 minutes at 3.33 m · s-1 on a treadmill dynamometer. Parameters were measured about 60 consecutive steps. Barefoot showed mainly lower contact and flight time (p < 0.05), passive peak (1.48 1.70 body weight, p higher braking pushing impulses pre-activation triceps surae muscles 0.05) than shod. It was concluded that when performed sufficient number steps, running leads reduction impact in reduce the high...
Purpose Mismatch repair (MMR) deficiency and microsatellite instability (MSI) are associated with cisplatin resistance in human germ cell tumors (GCTs). BRAF mutation (V600E) is found MSI colorectal cancers. The role of RAS/RAF pathway mutations GCT treatment response unknown. Patients Methods Two patient cohorts were investigated: 100 control GCTs (50 seminomas 50 nonseminomas) 35 cisplatin-based chemotherapy-resistant GCTs. MMR proteins analyzed by immunohistochemistry, eight loci examined...
Neural control of synergist muscles is not well understood. Presumably, each muscle in a synergistic group receives some unique neural drive and that also shared common with other the group. In this investigation, we sought to characterize strength, frequency spectrum, force dependence human vastus lateralis medialis during production isometric knee extension forces at 10 30% maximum voluntary effort. High-density surface electromyography recordings were decomposed into motor unit action...
Achilles (AT) and patellar tendons (PT) are commonly affected by tendinopathy in adult athletes but prevalence of symptoms morphological changes adolescents is unclear. The study aimed to determine intratendinous ATs PTs adolescent athletes. A total 760 (13.0 ± 1.9 years; 160 13 cm; 50 14 kg) were examined. History, local clinical examination, longitudinal Doppler ultrasound analysis for both performed including identification echoic vascularization. Diagnosis was complied clinically case...
Purpose Using a novel technique of high-density surface EMG decomposition and motor unit (MU) tracking, we compared changes in the properties vastus medialis lateralis MU after endurance (END) high-intensity interval training (HIIT). Methods Sixteen men were assigned to END or HIIT group (n = 8 each) performed six sessions for 14 d. Each session consisted 8–12 × 60-s intervals at 100% peak power output separated by 75 s recovery (HIIT) 90–120 min continuous cycling ~65% V˙O2peak (END). Pre-...
The aim of this trial was to investigate the addition anti-SLAMF7 monoclonal antibody elotuzumab lenalidomide, bortezomib, and dexamethasone (RVd) in induction consolidation therapy as well lenalidomide maintenance treatment transplant-eligible patients with newly diagnosed multiple myeloma.
Anaerobic threshold as a basic criterion of training recommendation can be estimated by various parameters. The purpose this study was to investigate the relationship and reproducibility ventilatory, lactate-derived aind catecholamine thresholds an incremental treadmill exercise. Therefore, 11 male subjects underwent two tests within 7 days. lactate (LT) determined at lowest value lactate-equivalent (ratio lactate/performance). individual anaerobic (IAT) calculated LT+1.5mmol/L lactate....
Sarcomas arising in the heart or great vessels are rare entities. The prognosis of patients is dismal.Between January 1993 and September 2006, 1,429 registered to Sarcoma Center, 14 had a primary sarcoma large vessels.Tumors were located left ventricle (n = 3), left/right atrium 2/3), pulmonary artery 2), ventricular septum, aorta, pericardium, inferior vena cava 1 each). most frequently encountered histologic subtypes leiomyosarcoma angiosarcoma. Six presented with distant metastases lungs...
PURPOSE: Testicular germ cell tumors (TGCTs) of adolescents and adults are very sensitive to systemic treatment. The exquisite chemosensitivity these cancers has been attributed a high level wild-type P53. MATERIALS AND METHODS: To clarify the role P53 in treatment sensitivity resistance TGCTs, we performed immunohistochemistry Western blotting analysis on series 39 fresh-frozen primary TGCTs before therapy (unselected series). In formalin-fixed paraffin-embedded patients with fully...
The therapeutic efficacy of non-surgical treatment strategies in Achilles tendinopathy (AT) has not been well clarified. Time-consuming and costly combinations for pain, physiotherapy biomechanical procedures are often applied.To analyse the single regimens commonly used over a short period 4 weeks.31 male runners (mileage >32 km/week) with unilateral, untreated AT completed weeks either (10 treatments: deep-friction, pulsed ultrasound, ice, sensory motor training; (P)), wearing custom fit...
Thymic carcinoma (TC) is a rare aggressive tumour. Median survival with current treatments only 2 years. Sunitinib multi-targeted tyrosine kinase inhibitor that has shown benefit in various other cancers. Laboratory analyses of snap-frozen tumour tissues were performed to detect activation and genetic mutations receptor kinases (RTKs) TC samples. On the basis molecular showing multiple RTKs their tumour, four patients metastatic TCs refractory conventional therapies treated sunitinib...
This phase II study evaluated the synthetic DNA-based immunomodulator and Toll-like receptor 9 agonist MGN1703 as maintenance treatment in metastatic colorectal carcinoma (mCRC).