A5029130844- Palliative Care and End-of-Life Issues
- Testicular diseases and treatments
- Cancer survivorship and care
- Childhood Cancer Survivors' Quality of Life
- Family Support in Illness
- Neuroblastoma Research and Treatments
- Sarcoma Diagnosis and Treatment
- Patient Dignity and Privacy
- Patient-Provider Communication in Healthcare
- Multiple Myeloma Research and Treatments
- Ovarian cancer diagnosis and treatment
- Grief, Bereavement, and Mental Health
- Urologic and reproductive health conditions
- Cancer Treatment and Pharmacology
- Glioma Diagnosis and Treatment
- Social and Demographic Issues in Germany
- Clinical practice guidelines implementation
- Ethics in medical practice
- Family and Patient Care in Intensive Care Units
- Medical and Health Sciences Research
- Genital Health and Disease
- Management of metastatic bone disease
- Sexual Differentiation and Disorders
- Intensive Care Unit Cognitive Disorders
- Pharmacological Effects and Toxicity Studies
Universität Hamburg
2016-2025
University Medical Center Hamburg-Eppendorf
2016-2025
Martini-Klinik
2012-2023
Klinik und Poliklinik für Neurologie
2012-2022
University Cancer Center Hamburg
2010-2022
University Hospital Münster
2022
National Experimental University of the Armed Forces
2021
Asklepios Klinik Barmbek
2021
Eppendorf (Germany)
2005-2014
University Children's Hospital Tübingen
2009
In November 2011, the Third European Consensus Conference on Diagnosis and Treatment of Germ-Cell Cancer (GCC) was held in Berlin, Germany. This third conference followed similar meetings 2003 (Essen, Germany) 2006 (Amsterdam, The Netherlands) [Schmoll H-J, Souchon R, Krege S et al. consensus diagnosis treatment germ-cell cancer: a report Group (EGCCCG). Ann Oncol 2004; 15: 1377-1399; S, Beyer J, R second meeting group (EGCCCG): part I. Eur Urol 2008; 53: 478-496; II. 497-513]. A panel 56 60...
Clinical management of germ cell tumours (GCTs) relies on monitoring serum tumour markers. However, the markers α-fetoprotein (AFP), β-subunit human chorionic gonadotropin (bHCG), and lactate dehydrogenase (LDH) are expressed in <60% GCT cases. To test utility microRNAs (miRNAs) miR-371a-3p, miR-372-3p, miR-373-3p, miR-367-3p as sensitive specific biomarkers. Serum levels miRNAs were measured 166 consecutive patients with before after treatment 106 male controls. In first 50 patients, all...
This pilot study aimed to investigate quality of life, psychological burden, unmet needs, and care satisfaction in family caregivers advanced cancer patients (FCs) during specialized inpatient palliative (SIPC) test feasibility acceptance the questionnaire survey.During a period 12 weeks, FCs were recruited consecutively within 72 h after patient's admission. They completed validated scales on several outcomes: life (SF-8), distress (DT), anxiety (GAD-7), depression (PHQ-9), supportive needs...
Purpose Mismatch repair (MMR) deficiency and microsatellite instability (MSI) are associated with cisplatin resistance in human germ cell tumors (GCTs). BRAF mutation (V600E) is found MSI colorectal cancers. The role of RAS/RAF pathway mutations GCT treatment response unknown. Patients Methods Two patient cohorts were investigated: 100 control GCTs (50 seminomas 50 nonseminomas) 35 cisplatin-based chemotherapy-resistant GCTs. MMR proteins analyzed by immunohistochemistry, eight loci examined...
Abstract Background This study prospectively evaluated distress, depressive and anxiety symptoms as well associated factors in family caregivers (FC) of advanced cancer patients at initiation specialist inpatient palliative care. Methods Within 72 h after the patient’s first admission, FCs were asked to complete German versions Distress Thermometer, Generalized Anxiety Disorder 7-item scale (GAD-7), Patient Health Questionnaire depression module 9-item (PHQ-9) for outcome measure....
Although current guidelines advocate early integration of palliative care, symptom burden and care needs patients at diagnosis incurable cancer along the disease trajectory are understudied.We assessed distress, burden, quality life, supportive in with newly diagnosed a prospective longitudinal observational multicenter study. Patients were evaluated using validated self-report measures (National Comprehensive Cancer Network Distress Thermometer [DT], Functional Assessment Therapy [FACT],...
Abstract Background Informal caregivers are key support for patients with progressive incurable diseases. However, their own needs often remain unmet. Therefore, we developed, manualised and implemented the intervention “Being an informal caregiver – strengthening resources” aiming to empower by addressing relevant information-related, physical, psychological social needs. Methods In this pilot study, evaluated acceptance experiences psychoeducational intervention. The study was conducted...
PURPOSE: To establish the predictive potential of 2- 18 fluoro-2-deoxy-d-glucose positron emission tomography (FDG PET) for detecting viable tumor tissue in residual postchemotherapy masses seminoma patients. PATIENTS AND METHODS: In this prospective multicenter trial, results FDG PET studies patients with ≥ 1 cm were correlated either histology resected lesion or clinical outcome on follow-up without resection. Negative scans lesions that devoid resection disappeared, shrunk, remained...
Abstract Objective : This longitudinal study examines the extent to which global meaning, existential distress in terms of demoralization, and depression are predicted by tumor stage (UICC stages 0–II vs III/IV), palliative treatment, physical problems cancer patients. Methods N = 270 patients were studied at baseline (T1, response rate: 41%) after 3 months (T2) ( 178, 72%). The following standardized self‐report measures used: Demoralization Scale, Life Attitude Profile—Revised, Hospital...
To investigate prevalence and predictors of postloss distress, depressive anxiety symptoms, quality life among bereaved family caregivers patients with advanced cancer.Prospective multicenter study. Family (N = 160, mean age 56.8 years, 66% female) completed validated outcome measures (Distress Thermometer, Generalized Anxiety Disorder 7-item scale, Patient Health Questionnaire depression module 9-item SF-8 Survey Questionnaire) 6 months after patient's discharge or death at specialist...
Given the important role caregivers play in palliative care planning and decision making, anxiety depression of terminally ill cancer patients their impact on caregivers' evaluation patients' physical psychological symptom burden were analyzed.Thirty-three recruited through University Medical Center inpatient ward <24 h after admission.Patients completed Memorial Symptom Assessment Scale (MSAS). Caregivers instructed to evaluate patient. Anxiety measured using PHQ-9 GAD-7.Fifty-five percent...