A5059697333- Acute Myeloid Leukemia Research
- Multiple Myeloma Research and Treatments
- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Protein Degradation and Inhibitors
- Acute Lymphoblastic Leukemia research
- Viral-associated cancers and disorders
- CAR-T cell therapy research
- Histone Deacetylase Inhibitors Research
- COVID-19 Clinical Research Studies
- RNA Research and Splicing
- SARS-CoV-2 and COVID-19 Research
- RNA modifications and cancer
- Childhood Cancer Survivors' Quality of Life
- Immune cells in cancer
- Erythrocyte Function and Pathophysiology
- Hematopoietic Stem Cell Transplantation
- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
- Chemokine receptors and signaling
- Long-Term Effects of COVID-19
- Hepatitis B Virus Studies
- Single-cell and spatial transcriptomics
Sun Yat-sen University
2018-2025
Sun Yat-sen University Cancer Center
2018-2025
Chang Gung Memorial Hospital
2025
Peking University
2025
Peking University Third Hospital
2025
Ministry of Education of the People's Republic of China
2025
Institute of Hematology & Blood Diseases Hospital
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
State Key Laboratory of Oncology in South China
2019-2023
Imperial College London
2023
To enhance therapeutic efficacy and reduce adverse effects, practitioners of traditional Chinese medicine (TCM) prescribe a combination plant species/minerals, called formulae, based on clinical experience. Nearly 100,000 formulae have been recorded, but the working mechanisms most remain unknown. In trying to address possible beneficial effects with current biomedical approaches, we use Realgar-Indigo naturalis formula (RIF), which has proven be very effective in treating human acute...
The full-length AML1-ETO ( AE ) fusion gene resulting from t(8;21)(q22;q22) in human acute myeloid leukemia (AML) is not sufficient to induce animals, suggesting that additional mutations are required for leukemogenesis. We and others have identified activating of C-KIT nearly half patients with t(8;21) AML. To test the hypothesis cooperate cause overt AML, we generated a murine transduction transplantation model both mutated . overcome intracellular transport block cells, engineered hybrid...
The new coronavirus pneumonia (NCP) is now causing a severe public health emergency. novel 2019 (2019-nCoV) infected individuals by binding human angiotensin converting enzyme II (ACE2) receptor. ACE2 widely expressed in multiple organs including respiratory, cardiovascular, digestive and urinary systems healthy individuals. These tissues with high expression level of seemed to be more vulnerable SARS-CoV-2 infection. Recently, it has been reported that patients tumors were likely...
Oridonin treats AML by generating a truncated version of the AML1-ETO oncoprotein that functions as tumor suppressor.
The prognostic significance of tumor-associated macrophages (TAMs) in multiple myeloma (MM) the era novel drugs remains unclear.CD163 expression was detected by immunohistochemistry to determine number TAMs 198 MM patients receiving bortezomib-based regimens and data were used evaluate its relevance with clinical characteristics, treatment response, prognosis.Patients high levels infiltrated CD163+ (>55/HPF) at diagnosis tended have more adverse characteristics.Patients TAM content had worse...
The HOXA gene family is associated with various cancer types. However, the role of genes in acute myeloid leukemia (AML) have not been comprehensively studied. We compared transcriptional expression, survival data, and network analysis HOXA-associated signaling pathways patients AML using ONCOMINE, GEPIA, LinkedOmics, cBioPortal, Metascape databases. observed that HOXA2-10 mRNA expression levels were significantly upregulated high HOXA1-10 was poor patient prognosis. altered ~18% samples,...
We aimed to assess the prognostic value of pretreatment inflammatory and nutritional parameters for predicting overall survival (OS) in patients with newly diagnosed multiple myeloma (NDMM), build a new scoring system using most important variables.We retrospectively analyzed baseline clinical laboratory data NDMM, who were randomly grouped into training validation cohorts at ratio 8:2. The Inflammatory Nutritional Score (INS) was developed based on least absolute shrinkage selection...
Abstract Causes of death in persons with haematological cancers include the index cancer, a new cancer or seemingly unrelated cause such as cardio-vascular disease. These causes are complex and sometimes confounded. We analyzed trends 683,333 an diagnosed 1975–2016 reported Surveillance, Epidemiology End Results dataset. Non-cancer deaths were described using standardized mortality ratios. The was predominant amongst plasma cell myeloma, acute lymphoblastic leukaemia myeloid leukaemia. major...
The standard treatment for periprosthetic joint infections (PJI) typically involves a two-stage resection arthroplasty using antibiotic-loaded bone cement (ALBC) spacers. This study hypothesizes that there is no significant correlation between antibiotic levels in blood and synovial fluid the patient's kidney function, success rates of staged are comparable groups, specifically targeting gram-positive bacterial infections. retrospective review included patients treated from 2017 to 2022 with...
Background: Patients with lower-risk myelodysplastic syndromes (MDS) may experience anemia and a high transfusion burden, alongside risk of progression to acute myeloid leukemia. Luspatercept, recombinant fusion protein that acts as an erythroid maturation agent, was FDA/EMA-approved in 2020 based on the phase III MEDALIST trial. There remains unmet need for treatment Asian patients whom red blood cell (RBC) is standard care, rates/severity serum erythropoietin levels are often higher versus...
Background: The perceptions of practicing physicians regarding the current situation and appropriateness shared decision-making (SDM) in life-sustaining treatment (LST) are essential importance. objective this study is to investigate clinical practice patterns barriers process China. Methods: A cross-sectional survey China was conducted assess perceived practices SDM LST. instrument developed through Delphi method. Descriptive analyses an exploratory factor analysis were performed explore...
Abstract Purpose: Prediction models for acute myeloid leukemia (AML) are useful, but have considerable inaccuracy and imprecision. No current model includes covariates related to immune cells in the AML microenvironment. Here, an risk score was explored predict survival of patients with AML. Experimental Design: We evaluated predictive accuracy several silico algorithms composition based on a reference multi-parameter flow cytometry. CIBERSORTx chosen enumerate from public datasets develop...
Circulating tumor DNA (ctDNA) carries tumor-specific genetic and epigenetic variations. To identify extranodal natural killer/T cell lymphoma (ENKTL)-specific methylation markers establish a diagnostic prognosis prediction model for ENKTL, we describe the ENKTL-specific ctDNA patterns by analyzing profiles of ENKTL plasma samples. We construct based on with both high specificity sensitivity close relevance to staging therapeutic response. Subsequently, built prognostic showing excellent...
Abstract Background Aponermin, a circularly permuted tumor necrosis factor-related apoptosis-inducing ligand, is potential death receptor 4/5-targeted antitumour candidate. Previous phase 1/2 studies have demonstrated the efficacy of aponermin in patients with relapsed or refractory multiple myeloma (RRMM). To confirm superiority plus thalidomide and dexamethasone (aponermin group) over placebo (placebo RRMM, randomized, double-blinded, controlled 3 trial was performed. Methods Four hundred...