A5101866267- Optical Coherence Tomography Applications
- Coronary Interventions and Diagnostics
- Electrospun Nanofibers in Biomedical Applications
- Cardiac Imaging and Diagnostics
- Protein Hydrolysis and Bioactive Peptides
- Tissue Engineering and Regenerative Medicine
- Radiomics and Machine Learning in Medical Imaging
- Retinal Imaging and Analysis
- CAR-T cell therapy research
- Meat and Animal Product Quality
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Extracellular vesicles in disease
- Research on Leishmaniasis Studies
- Melanoma and MAPK Pathways
- Antiplatelet Therapy and Cardiovascular Diseases
- Proteins in Food Systems
- Multiple Myeloma Research and Treatments
- Medical Imaging Techniques and Applications
- Graphene and Nanomaterials Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Lung Cancer Diagnosis and Treatment
- Cell death mechanisms and regulation
- Muscle Physiology and Disorders
- Nanocomposite Films for Food Packaging
Shanghai Jiao Tong University
2023-2025
Ministry of Agriculture and Rural Affairs
2024-2025
Hubei Academy of Agricultural Sciences
2024-2025
Mitchell Institute
2025
Texas A&M University
2025
The Third Affiliated Hospital of Zhejiang Chinese Medical University
2023
Affiliated Hospital of Qingdao University
2023
Qingdao University
2023
Tianjin Medical University Cancer Institute and Hospital
2013
Abstract As one of the most intractable neurological diseases, spinal cord injury (SCI) often leads to permanent impairment in patients. Unfortunately, due complex pathological mechanisms and unique postinjury microenvironment, there is currently no way completely repair injured cord. In recent years, with rapid development tissue engineering technology, combination biomaterials medicine has provided a new idea for treating SCI. Here, we systematically summarize representative biomaterials,...
In this study, a novel antifreeze peptide was isolated from crayfish shells and its mechanism activity were investigated. Firstly, the peptides (CSPs) prepared by Enzymatic Hydrolysis Technology (alkaline protease trypsin) CSPs could significantly enhance survival rate of Saccharomyces cerevisiae 12.5% to 88.5% after 24h freeze-thaw cycle. Then, total 1004 identified liquid chromatography/tandem mass spectrometry (LC-MS/MS), among those peptides, two sequences YWDHPIRDGFAPH (AFP1)...
Abstract Spinal cord injury (SCI) represents a profound central nervous system affliction, resulting in irreversibly compromised daily activities and disabilities. SCI involves excessive inflammatory responses, which are characterized by the existence of high levels proinflammatory M1 macrophages, neuronal mitochondrial energy deficit, exacerbating secondary damage impeding axon regeneration. This study delves into mechanistic intricacies SCI, offering insights from perspectives neuroimmune...
The registration of coronary artery structures from preoperative computed tomography angiography to intraoperative is great interest improve guidance in percutaneous interventions. However, non-rigid deformation and discrepancies both dimensions topology between the two imaging modalities present a challenge 2D/3D registration. In this study, we address problem by formulating it as centerline feature matching task propose GNN-based vessel network (GVM-Net) establish dense correspondence...
Abstract Background Aponermin, a circularly permuted tumor necrosis factor-related apoptosis-inducing ligand, is potential death receptor 4/5-targeted antitumour candidate. Previous phase 1/2 studies have demonstrated the efficacy of aponermin in patients with relapsed or refractory multiple myeloma (RRMM). To confirm superiority plus thalidomide and dexamethasone (aponermin group) over placebo (placebo RRMM, randomized, double-blinded, controlled 3 trial was performed. Methods Four hundred...
Abstract Volumetric muscle loss (VML) is a severe form of trauma that exceeds the regenerative capacity skeletal tissue, leading to substantial functional impairment. The abnormal immune response and excessive reactive oxygen species (ROS) accumulation hinder regeneration following VML. Here, an interfacial cross‐linked hydrogel‐poly(ε‐caprolactone) nanofiber composite, incorporates both biophysical biochemical cues modulate ROS microenvironment for enhanced VML repair, engineered....
The FORZA trial (FFR or OCT Guidance to Revascularize Intermediate Coronary Stenosis Using Angioplasty) prospectively compared the use of fractional flow reserve (FFR) optical coherence tomography (OCT) for treatment decisions and percutaneous coronary intervention (PCI) optimization in patients with angiographically intermediate lesions. Murray law-based quantitative-flow-ratio (μQFR) is a novel noninvasive method computation FFR. In present study, we evaluated clinical impact μQFR, FFR,...
Abstract Background The combination of coronary imaging assessment and blood flow perturbation estimation has the potential to improve percutaneous intervention (PCI) guidance. Objectives We aimed evaluate a novel method for fast computation Murray law‐based quantitative ratio (μQFR) from coregistered optical coherence tomography (OCT) angiography (OCT‐modulated μQFR, OCT‐μQFR) in predicting physiological efficacy PCI. Methods Patients treated by OCT‐guided PCI OCT‐arm Fractional Flow...
Pain-related aversive memory is common in chronic pain patients. Electroacupuncture has been demonstrated to block pain-related memory. The insular cortex a key region closely related behaviors. In our study, potential mechanism underlying the effect of electroacupuncture treatment on behaviors relative was investigated. Our study used chemogenetic method, pharmacological intervention, and behavioral detection. showed that both inhibition gamma-aminobutyric acidergic neurons activation kappa...
<title>Abstract</title> The composited hydrogels derived from natural materials are getting attention in the field of cultured meat due to their advantages biocompatibility and degradability as cell scaffolds. In this work, two edible cross-linking agents, transglutaminase (TGase) and/or calcium ions, were successfully used cross-link soy protein isolated (SPI) dietary fiber (SDF) fabricate different prepared scaffolds characterized by structural, hydration, rheological mechanical analysis....
Immune checkpoint inhibitor-associated myocarditis is the most lethal side effect of immune blockade. Myocarditis leads to persistently increased mortality and lacks effective treatments. The development patient-relevant disease models may enable prediction, understanding pathophysiology, treatment strategies. Here, we report a new method model
7567 Background: Assessing the efficacy of molecularly targeted agents, especially in absence tumor shrinkage, remains a challenge. The primary objective this prospective international trial was to evaluate whether on-treatment 18F-deoxyglucose (FDG) and 18F-deoxythymidine (FLT) PET responses predict improved progression-free (PFS) overall survival (OS) following treatment 2nd/3rd line NSCLC with E, an epidermal growth factor receptor (EGFR) inhibitor. Methods: Study assessments included...
Introduction: Immune checkpoint inhibitor-associated myocarditis (ICI myocarditis) is a severe side effect of treating malignancies with immune inhibitors. Patients suffering from ICI often display an extraordinarily high mortality rate. Establishing clinically relevant model to address the lack identifiable risk factors, screening tests, or effective treatments critically urgent. Hypothesis: Human can be accurately modeled in vitro. Methods and Results: We present first cell culture-based...