A5068166337- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Radiation Dose and Imaging
- Microtubule and mitosis dynamics
- Advanced Radiotherapy Techniques
- Advanced MRI Techniques and Applications
- Cancer, Hypoxia, and Metabolism
- Advanced X-ray and CT Imaging
- Prostate Cancer Treatment and Research
- Lymphoma Diagnosis and Treatment
- MRI in cancer diagnosis
- Cancer Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Cardiac Imaging and Diagnostics
- PARP inhibition in cancer therapy
- Lung Cancer Diagnosis and Treatment
- Cancer-related Molecular Pathways
- Neuroendocrine Tumor Research Advances
- Medical Imaging and Pathology Studies
- Peptidase Inhibition and Analysis
- Management of metastatic bone disease
- Lung Cancer Treatments and Mutations
- Gallbladder and Bile Duct Disorders
- Meningioma and schwannoma management
The University of Texas Southwestern Medical Center
2022-2024
Texas A&M University
2023-2024
Mitchell Institute
2024
Translational Research in Oncology
2023
Vibrant Data (United States)
2023
University of Houston
2023
UPMC Presbyterian
2015-2021
University of Pittsburgh
2016-2021
Nova Southeastern University
2021
University of Pittsburgh Medical Center
2018-2021
We report our initial clinical experience for image quality and diagnostic performance of a digital PET prototype scanner with time-of-flight (DigitalTF), compared an analog (GeminiTF PET/CT). <b>Methods:</b> Twenty-one oncologic patients, mean age 58 y, first underwent <sup>18</sup>F-FDG PET/CT on the GeminiTF. The table was then withdrawn while patient remained table, DigitalTF inserted between GeminiTF CT scanner. patients were scanned second time using same field view from attenuation...
Self-assembly has emerged as a paradigm for highly parallel fabrication of complex three-dimensional structures. However, there are few principles that guide priori design, yield, and defect tolerance self-assembling We examine with experiment theory the geometric underlie self-folding submillimeter-scale higher polyhedra from two-dimensional nets. In particular, we computationally search nets within large set possibilities then test these experimentally. Our main findings ( i ) compactness...
Abstract Replication stress is a characteristic feature of cancer cells, which resulted from sustained proliferative signaling induced by activation oncogenes or loss tumor suppressors. In oncogene-induced replication manifests as replication-associated lesions, predominantly double-strand DNA breaks (DSBs). An essential mechanism utilized cells to repair DSBs homologous recombination (HR). order overcome and survive, often require enhanced HR capacity. Therefore, the key link between...
The aim of this retrospective study was to report the prevalence and patterns soft tissue (ST) metastasis detected with true whole-body (TWB) F-18 FDG PET/CT acquired from top skull through bottom feet compare such findings that typically skull-base upper-thigh, thus limited (LWB) field view (FOV).TWB FDG-PET/CT scans were performed in 500 consecutive cancer patients. Suspected ST verified by correlation surgical pathology, other imaging modalities, or clinical follow-up.Nine out patients...
Purpose. We retrospectively compared the maximum standard uptake value (SUVmax) of FDG PET in four different sites to evaluate whether a common diagnostic SUVmax threshold may exist these tumor locations. further postulate that thresholds are higher thoracic lesions than extrathoracic lesions. Material and methods. N = 143 patients subgroups underwent PET/CT: a) 42 for solitary pulmonary nodules (SPNs) characterization with b) respective mediastinal lymph nodes (LNs), c) 65 LN staging head...
The current study characterized pleural changes induced by talc pleurodesis (TP), based on serial positron emission tomography/computer-tomography (PET/CT) with F-18 fluorodeoxyglucose (FDG).A total of 8 cancer patients who had both TP and PET/CT no evidence active involvement after were retrospectively evaluated. Maximum standard uptake values, maximum Hounsfield units (HU), thickness followed over time.The 25 scans performed in an average 22 months TP. An increased FDG was associated...
Introduction: This pilot study aimed at exploring the utility of proliferation tracer F-18 FLT (FLT) and PET/MRI (FLT-PET/MRI) for early treatment monitoring in patients with melanoma brain metastasis (MBM) who undergo targeted therapy or immunotherapy. Material Methods: Patients newly diagnosed MBM underwent baseline follow-up FLT-PET/MRI scans 3-4 weeks Up to 6 measurable lesions ≥ 1.0 cm per subject, as identified on T1-weighted post-Gd images, were included quantitative analyses. The...
Use of the routine field view for whole-body (18)F-FDG PET/CT can lead to underestimation true extent disease because metastasis outside typical base skull upper thigh be missed. The purpose this study was evaluate incremental added value as opposed limited cancer patients.True FDG PET/CT, from top bottom feet, performed on 500 consecutively registered patients. A log kept cases suspected malignancy view. Suspected lesions in brain, skull, and extremities were verified by correlation with...
Preoperative F-18 FDG PET/CT study in this 57-year-old woman showed an avid lesion the left upper lung without evidence of lymphadenopathy or distant metastasis. She underwent a lobectomy June 2005 revealing moderately poorly differentiated adenocarcinoma (pT3N0M0) and subsequent chemotherapy completed December 2005. Nine months later, parietal lobe metastatic was surgically resected. A true whole body November 2006 for restaging demonstrated new spinal cord foci, which were highly...
Background Increased cerebral signal intensity (SI) has been reported in patients undergoing MRI with gadolinium-based contrast agents (GBCAs). Published data on gadobenate dimeglumine have somewhat contradictory. Purpose To evaluate the relationship between dosage of and SI change at following multiple administrations. Materials Methods In this retrospective study, referred for clinically indicated brain from January 2006 through May 2016 were evaluated inclusion. Eligible 18 90 years old...
Abstract We evaluated the potential differences of a digital positron-emission tomography (PET) prototype equipped with photon-counting detectors (D-PET, Philips Healthcare, Cleveland, Ohio, USA) in tumor volume delineation compared analog Gemini TF PET system (A-PET, Philips). Eleven oncologic patients first underwent clinical fluorodeoxyglucose (FDG) PET/computed (CT) on A-PET. The D-PET ring was then inserted between and CT scanner A-PET patient scanned for second time. Two interpreters...
We report our PET/MRI experience from a pilot study that compared the diagnostic performance of <sup>18</sup>F-FDG versus PET/CT in staging cervical cancer. <b>Methods:</b> Six adults with newly diagnosed cancer underwent single injection dual-imaging protocol: standard-of-care followed by research PET/MRI. The interpretation and SUV<sub>max</sub> for 2 modalities were compared. <b>Results:</b> Both detected all primary tumors (median size, 3.9 cm) 4 metastases present 6 patients 0.9 cm)....
Extrapulmonary small cell carcinoma (EPSCC) involving the brain is a rare manifestation of an uncommon tumor type. We report 59 year-old Caucasian female diagnosed with EPSCC left parietal lobe without detectable extracranial primary followed by serial positron emission tomography/computed tomography (PET/CT) imaging. Histopathological examination at both initial presentation and recurrence revealed carcinoma. Serial PET/CT scans entire body failed to reveal any...
Our objective was to evaluate the incidence of aneurysm and frequency thrombus within an on unenhanced <sup>18</sup>F-FDG PET/CT studies. <b>Methods:</b> We reviewed 1,540 scans from 926 patients. A log recorded whether each case had a suspected thrombus. The maximal standardized uptake value patent vessel compared with Findings were confirmed using all available follow-up data. <b>Results:</b> Aneurysm found incidentally in 16 (1.7%) patients, 15 occurring abdominal aorta 1 internal jugular...
We present the case of a 77 year old male with history prostate cancer. Follow up PET-CT and contrast-enhanced CT demonstrated small peritoneal loose body or “mouse” in pelvis. This is an uncommon, benign, asymptomatic finding which usually incidentally discovered. The significance being aware this entity to distinguish it from metastasis, especially patients known abdominal pelvic malignancies.
A 74-year-old man with 40-year history of smoking and known chronic lymphocytic leukemia cutaneous T-cell lymphoma underwent FDG PET/CT examination for a recent diagnosis squamous cell carcinoma diagnosed from right frontal crown left posterior ear skin biopsy. PET images revealed multiple FDG-avid lesions in the head neck, highly suspicious nodal metastases. Reviewing CT portion hyperattenuating density bladder wall. This lesion was not noticed initially due to intense physiologic uptake....