A5060538017- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- Cancer, Hypoxia, and Metabolism
- Cytomegalovirus and herpesvirus research
- Lymphoma Diagnosis and Treatment
- Pancreatitis Pathology and Treatment
- Drug Transport and Resistance Mechanisms
- Cell death mechanisms and regulation
- Histone Deacetylase Inhibitors Research
- Cancer-related Molecular Pathways
- Retinoids in leukemia and cellular processes
- Multiple Myeloma Research and Treatments
- Protein Degradation and Inhibitors
- RNA Research and Splicing
- Metabolism, Diabetes, and Cancer
- DNA Repair Mechanisms
- Autophagy in Disease and Therapy
- Ubiquitin and proteasome pathways
- Peptidase Inhibition and Analysis
- Pancreatic function and diabetes
- Bone health and treatments
- Viral Infections and Vectors
- Quinazolinone synthesis and applications
- ATP Synthase and ATPases Research
Shanghai Jiao Tong University
2011-2024
Sichuan University
2010-2024
XinHua Hospital
2022-2024
Shanghai Institute of Nutrition and Health
2021-2024
Sun Yat-sen University
2016-2024
Third Affiliated Hospital of Sun Yat-sen University
2016-2024
Dalian Medical University
2021-2022
Second Affiliated Hospital of Dalian Medical University
2021
Tongren Hospital
2021
Shanghai First People's Hospital
2021
Abstract Identifying novel drug targets to overcome resistance tyrosine kinase inhibitors (TKIs) and eradicating leukemia stem/progenitor cells are required for the treatment of chronic myelogenous (CML). Here, we show that ubiquitin-specific peptidase 47 (USP47) is a potential target TKI resistance. Functional analysis shows USP47 knockdown represses proliferation CML sensitive or resistant imatinib in vitro vivo. The knockout Usp47 significantly inhibits BCR-ABL T315I -induced mice with...
The Qinghai-Tibet Plateau is facing a crisis of ecological degradation against background global warming and the intensification human activities. With aim evaluating spatial temporal distribution vulnerability, this study established new comprehensive pressure-state-response-management (PSRM) model based on differences in relative importance indicators vulnerability evaluation system different regions. factors influencing were determined by calculating correlation coefficient between index...
Oridonin treats AML by generating a truncated version of the AML1-ETO oncoprotein that functions as tumor suppressor.
Homoharringtonine (HHT), a known protein synthesis inhibitor, has an anti-myeloid leukemia effect and potentiates the therapeutic efficacy of anthracycline/cytarabine induction regimens for acute myelogenous (AML) with favorable intermediate prognoses, especially in t(8;21) subtype. Here we provide evidence showing that HHT inhibits activity leukemia-initiating cells (Lin − /Sca-1 /c-kit + ; LICs) murine model exerts down-regulating on MYC pathway genes human (Kasumi-1). We discovered NF-κB...
Abstract Increasing evidence suggests that global downregulation of miRNA expression is a hallmark human cancer, potentially due to defects in the processing machinery. In this study, we found protein Argonaute 2 (AGO2), key regulator processing, was downregulated colorectal cancer (CRC) tissues, which also consistent with findings Clinical Proteomic Tumor Analysis Consortium (CPTAC). Furthermore, correlation between levels AGO2 and epithelial-mesenchymal transition (EMT) markers (E-cadherin...
The tumor suppressor p53 is regulated in part by binding to cellular proteins. We used as bait the yeast two-hybrid system and isolated homeodomain-interacting protein kinase 1 (HIPK1) a p53-binding protein. Deletion analysis showed that amino acids 100-370 of 885-1093 HIPK1 were sufficient for HIPK1-p53 interaction. was capable autophosphorylation specific serine phosphorylation p53. gene highly expressed human breast cancer cell lines oncogenically transformed mouse embryonic fibroblasts....
<h2>Abstract</h2> The pyruvate kinase (PK) is a rate-limiting glycolytic enzyme catalyzing the dephosphorylation of phosphoenolpyruvate to pyruvate, yielding one molecule ATP. M2 isoform PK (PKM2) predominantly expressed in normal proliferating cells and tumors, both metabolic non-metabolic activities for promoting tumor cell proliferation have been identified. However, exact roles PKM2 initiation, growth maintenance are not yet fully understood. Using immunoprecipitation-coupled LC-MS/MS...
Abstract Leukemia arises from blockage of the differentiation/maturation hematopoietic progenitor cells at different stages with uncontrolled proliferation leukemic cells. However, signal pathways that block cell differentiation remain unclear. Herein we found SUMOylation M2 isoform pyruvate kinase (PKM2), a rate-limiting glycolytic enzyme catalyzing dephosphorylation phosphoenolpyruvate to pyruvate, is prevalent in variety lines as well primary samples patients leukemia through...
Chronic myelogenous leukemia (CML) is a hematological stem cell disorder. Tyrosine kinase inhibitors (TKIs) are the standard treatments for CML, but number of patients fail to respond effectively due gene mutations. Celecoxib, cyclooxygenase-2 (COX-2) inhibitor, has been shown have anti-tumor effect on solid tumor whereas anti-CML and its underlying mechanism not completely elucidated. The cytotoxic effects celecoxib and/or imatinib were evaluated by MTT assay. Cell cycle distribution was...
Regenerating gene family member 4 (REG4) is a novel marker for enteroendocrine cells and selectively expressed in specialised of the small intestine. However, exact roles REG4 are largely unknown. In this study we investigate effects on development dietary fat-dependent liver steatosis mechanisms involved.Mice with intestinal-specific Reg4 deficiency (Reg4ΔIEC ) Reg4-floxed alleles (Reg4fl/fl were generated to diet-induced obesity steatosis. Serum levels also measured children using...
Pyruvate kinase (PK) catalyzes the conversion of phosphoenolpyruvate and ADP to pyruvate ATP, a rate-limiting reaction in glycolysis. M2 isoform PK (PKM2) is predominant form expressed tumors. In addition its well established cytosolic functions as glycolytic enzyme, PKM2 displays nuclear localization important nonmetabolic tumorigenesis. Herein, we report that interacts with histone H2AX under DNA damage conditions. Depletion decreased level serine 139-phosphorylated (γ-H2AX) response...
Critical determinants of DNA recognition by p53 have been identified a molecular genetic approach. The wild-type human fragment containing amino acids 71 to 330 (p53(71-330)) was used for in vitro binding assays, and full-length transactivation assays with Saccharomyces cerevisiae. First, we defined the specificity using systematically altered forms known consensus site. This refinement indicates that binds high affinity two repeats PuGPuCA.TGPyCPy, further an earlier half site...
Abstract AML1‐ETO, a fusion protein generated by the chromosomal translocation t(8;21), is frequently associated with acute myeloid leukemia (AML). In addition to blocking differentiation, AML1‐ETO also shown induce growth arrest in AML cells, which unfavorable for leukemogenesis harboring t(8;21) translocation. However, its precise mechanism still unclear. Here we provide first demonstration that conditional expression of ecdysone‐inducible system dramatically increases connexin 43 (CX43),...
Abstract Chronic myeloid leukemia (CML) are initiated and sustained by self-renewing malignant CD34 + stem cells. Extensive efforts have been made to reveal the metabolic signature of stem/progenitor cells in genomic, transcriptomic, metabolomic studies. However, very little proteomic investigation has conducted mechanism regarding at what level program was rewired remains poorly understood. Here, using label-free quantitative profiling, we compared collected from CML individuals with that...
Caspases, a family of aspartate-specific cysteine proteases, play major role in apoptosis and variety physiological pathological processes. Fourteen mammalian caspases have been identified can be divided into two groups: inflammatory apoptotic caspases. Based on the structure function, are further grouped initiator/apical (caspase-2, -8, -9, -10) effector/executioner (caspase-3, -6, -7). In this paper, we discuss what learned about individual effector caspase mediating both nonapoptotic...
The development of targeted tyrosine kinase inhibitors (TKIs) has succeeded in altering the course chronic myeloid leukemia (CML). However, a number patients have failed to respond or experienced disease relapse following TKI treatment. Proviral integration site for moloney murine virus‑1 (PIM‑1) is serine/threonine that participates regulating apoptosis, cell cycle, signal transduction and transcriptional pathways, which are associated with tumor progression, poor prognosis. SMI‑4a...