A5101923179- Lung Cancer Treatments and Mutations
- Blood donation and transfusion practices
- Histone Deacetylase Inhibitors Research
- Mesenchymal stem cell research
- Hemoglobinopathies and Related Disorders
- Chronic Lymphocytic Leukemia Research
- Reconstructive Surgery and Microvascular Techniques
- Glioma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Lung Cancer Research Studies
- Iron Metabolism and Disorders
- Neurogenesis and neuroplasticity mechanisms
- Remote Sensing and LiDAR Applications
- Quinazolinone synthesis and applications
- Diabetes Management and Education
- Proteoglycans and glycosaminoglycans research
- Anatomy and Medical Technology
- Cancer therapeutics and mechanisms
- Endoplasmic Reticulum Stress and Disease
- Satellite Image Processing and Photogrammetry
- Cancer Cells and Metastasis
- Brain Metastases and Treatment
- Geological Modeling and Analysis
- Platelet Disorders and Treatments
- Angiogenesis and VEGF in Cancer
Lanzhou University
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2011-2022
Tianjin Medical University Cancer Institute and Hospital
2015-2021
Anhui Medical University
2011-2019
First Affiliated Hospital of Anhui Medical University
2011-2019
National Clinical Research
2019
St. Michael's Hospital
2017
University of Toronto
2017
Canadian Blood Services
2017
China University of Geosciences (Beijing)
2010
Environmental exposure to heavy metals may adversely affect lung function particularly in the elderly. However, limited data are available directly evaluating relationship of metal exposures with Chinese We aimed investigate associations between plasma and among elderly residents. conducted a cross-sectional study 308 residents an industrial area non-industrial northwest China estimated single combined effects their interactions functions (forced vital capacity [FVC], forced expiratory...
Abstract Brain metastasis is a significant unmet clinical problem in breast cancer treatment. It always associated with poor prognosis and high morbidity. Recently, Slit2/Robo1 pathway has been demonstrated to be involved the progression of carcinoma. However, until present, there are no convincing reports that suggest whether axis any role brain cancer. In this study, we investigated correlation between signaling for first time. Our results (1) Invasive ductal carcinoma patients low...
In diabetes, the number of bone mesenchymal stem cells (MSCs) decreases and their differentiation is impaired. However, exact mechanism unclear. Patients with diabetes often experience sympathetic nerve injury. Norepinephrine (NE), a major mediator nervous system, influences rat MSC migration in culture vivo. The present study aimed to investigate effect NE on MSCs under high glucose conditions; therefore were treated NE. High glucose-induced apoptosis, which was reversed by To verify NE,...
GDF11, a member of TGF-β superfamily, has recently received widespread attention as novel anti-ageing/rejuvenation factor to reverse age-related dysfunctions in heart and skeletal muscle, induce angiogenesis neurogenesis. However, these positive effects GDF11 were challenged by several other studies. Furthermore, the mechanism is still not well understood. In present study, we evaluated on C17.2 neural stem cells. induced differentiation apoptosis, suppressed migration addition, slightly...
The study was performed to investigate the antitumor efficacy of histone deacetylase inhibitor (HDACi) chidamide alone or with epidermal growth factor receptor tyrosine kinase (EGFR-TKI) icotinib in non-small cell lung cancer (NSCLC).The viability, cycle, apoptosis, protein expression, and molecular mechanisms were explored among ten NSCLC lines combination, further validated xenograft models nude mice.Chidamide significantly reduced viability A549, HCC827, HCC827IR (icotinib resistant)...
Brain metastasis is an unsolved clinical problem in breast cancer patients due to its poor prognosis and high fatality rate. Although accumulating evidence has shown that some pan-histone deacetylase (HDAC) inhibitors can relieve brain metastasis, the specific HDAC protein involved this process unclear. Thus, identifying a closely correlated with will not only improve our understanding of functions family but also help develop novel target for precision therapy.Immunohistochemical staining...
Objective . Cytokine-induced apoptosis inhibitor 1 (CIAPIN1) acts as a downstream effector of the receptor tyrosine kinase-Ras signaling pathway and has been reported candidate tumor suppressor gene in various cancers. Our current study was aimed at investigating prognostic impact CIAPIN1 on Non-Small-Cell Lung Carcinoma (NSCLC) patients effect NSCLC A549 cells’ metastasis. Methods Western blot analysis applied to detect expression; Kaplan-Meier survival used evaluate patients’ prognosis....
Previous in vivo and vitro studies have shown that human mesenchymal stem cells (MSCs) exhibit tropism for gliomas. However, the mechanism underlying this directed migration remains unclear. The aim of present study was to investigate possible platelet-derived growth factor‑BB (PDGF‑BB)-induced chemotactic bone marrow-derived MSCs (BMSCs) toward glioma. Rat glioma C6 cell-conditioned medium utilized evaluate response BMSCs using an assay. Recombinant rat PDGF-BB added cell‑conditioned assess...
Abstract The echinoderm microtubule associated protein‐like 4 gene ( EML4 ) encodes the predominant anaplastic lymphoma kinase ALK fusion partner in non‐small‐cell lung cancer (NSCLC); however, dynactin subunit 1 DCTN1 )‐ rearrangement is extremely rare. co‐occurrence of primary epidermal growth factor receptor (EGFR) T790M mutation with EGFR exon 19 deletion (del) patients NSCLC uncommon. Here we report a female adenocarcinoma patient brain metastases and possible coexistence mutation/ del/...
Objective: More than half of human glioblastomas show EGFR gene amplification and mutation, but inhibitors have not been effective in treating EGFR-positive glioblastoma patients. The mechanism behind this type primary resistance is well understood. aim study was to investigate gefitinib glioblastoma, explore ways circumvent significant clinical problem. Methods: MTT method used test the cell viability after cells were treated with indicated drugs; real-time quantitative PCR included detect...
Neuromyelitis optica (NMO) is a refractory autoimmune inflammatory disease of the central nervous system without an effective cure. Autologous bone marrow‑derived mesenchymal stem cells (BM‑MSCs) are considered to be promising therapeutic agents for this due their potential regenerative, immune regulatory and neurotrophic effects. However, little known about cytological features BM‑MSCs from patients with NMO, which may influence any The present study aimed compare proliferation,...
Efficient, accurate and low-cost estimation of human skeletal information is crucial for a range applications such as biology education human-computer interaction. However, current simple skeleton models, which are typically based on 2D-3D joint points, fall short in terms anatomical fidelity, restricting their utility fields. On the other hand, more complex models while anatomically precise, hindered by sophisticate multi-stage processing need extra data like skin meshes, making them...