A5100432768- Glioma Diagnosis and Treatment
- Mesenchymal stem cell research
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Bone Metabolism and Diseases
- Circular RNAs in diseases
- Tissue Engineering and Regenerative Medicine
- Hemoglobinopathies and Related Disorders
- Chronic Lymphocytic Leukemia Research
- Cytokine Signaling Pathways and Interactions
- Cancer-related gene regulation
- Bone health and treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Tryptophan and brain disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Stress Responses and Cortisol
- Genomics, phytochemicals, and oxidative stress
- Cancer, Lipids, and Metabolism
- S100 Proteins and Annexins
- Muscle Physiology and Disorders
- Cancer Cells and Metastasis
- PI3K/AKT/mTOR signaling in cancer
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer Mechanisms and Therapy
- Plant Gene Expression Analysis
Guangdong Medical College
2014-2025
Hunan University of Traditional Chinese Medicine
2024
Guangdong Ocean University
2022-2024
Sun Yat-sen University
2023
Ningxia University
2022
Second Affiliated Hospital of Zhejiang University
2022
China Medical University
2021
Beijing Tian Tan Hospital
2021
Liaocheng People's Hospital
2021
Henan Agricultural University
2019
Abstract Introduction Osteoarthritis (OA) is an inflammatory disease of the joints that causes progressive disability in elderly. Reactive oxygen species (ROS) play important role OA development; they may activate NLRP3 inflammasome, thereby inducing secretion proinflammatory IL-1β and IL-18, leading to aggravation downstream response. Nrf2 a key transcription factor regulates expression antioxidant enzymes protect against oxidative stress tissue damage. We aimed explore underlying mechanism...
Bruton's tyrosine kinase (BTK), a nonreceptor kinase, is member of the Tec family kinases. BTK plays an essential role in B cell receptor (BCR)-mediated signaling as well Fcγ monocytes and Fcε mast cells basophils, all which have been implicated pathophysiology autoimmune disease. As result, inhibition anticipated to provide effective strategy for clinical treatment diseases such lupus rheumatoid arthritis. This article details structure–activity relationships (SAR) leading novel series...
Microglia activation, increased IL-6 and decreased TGF-β were found in depressed patients or animal models of depression. enhances T helper 17 cell differentiation, thereby causing an imbalance between Th17 Treg cells, which induces neuroinflammation neuronal dysfunction. However, whether imbalances occur depression can be improved upon restoring these are unknown. promoter IL-2 (1500UI/0.1 mL/day) was used to treat a mouse model induced by chronic unpredictable mild stress (CUMS). The...
Osteoporosis (OP) is the most common bone disorder worldwide, especially in postmenopausal women. However, many OP drugs are not suitable for long term use due to major adverse effects. Therefore, there an urgent need identify more effective and safe therapeutic drugs. Pueraria lobata has been reported promote osteoblast growth regeneration, but exact mechanisms still further exploration. The current study found that lobata-derived exosome-like nanovesicles (PELNs) promoting primary human...
Background— Allogeneic mesenchymal stem cells (MSCs) were immunoprivileged early after cardiac implantation and improved heart function in preclinical clinical studies. However, long-term studies demonstrated that allogeneic MSCs lost their immunoprivilege rejected the injured myocardium, resulting recurrent ventricular dysfunction. This study identifies some of mechanisms responsible for immune switch suggests a new treatment to maintain preserve function. Methods Results— Rat MSC was...
Clinical prevalence of major depression is higher in women than men, while the psychoneuroimmunological mechanisms underlying differences between two sexes are not fully understood.The present study explored sex behaviors and depressive pathological induced by chronic unpredictable mild stress (CUMS). Depression- anxiety-like were assessed sucrose preference test (SPT), force swimming (FST), open field (OFT), elevated plus-maze (EPM). The enzyme-linked immunosorbent assay (ELISA) was used to...
Introduction: Osteosarcoma is a prevalent and highly malignant primary bone tumor. However, current clinical therapeutic drugs for osteosarcoma are not suitable long-term use due to significant side effects. Therefore, there an urgent need develop new with fewer Dipsacus asperoides C. Y. Cheng et T. M. Ai, traditional Chinese medicine, commonly used its anti-inflammatory, anti-pain, fracture healing, anti-tumor In this study, we investigated the effects of exosome-like nanoparticles derived...
Abstract Allogeneic mesenchymal stem cell ( MSC ) transplantation improves cardiac function, but cellular differentiation results in loss of immunoprivilege and rejection. To explore the mechanism involved this immune rejection, we investigated influence interleukin‐6 (IL‐6), a factor secreted by s, on privilege after myogenic, endothelial smooth muscle induced 5‐azacytidine, VEGF , transforming growth factor‐β TGF ‐β), respectively. Both RT ‐ PCR ELISA showed that myogenic s was associated...
Carotenoid cleavage dioxygenases (CCDs) selectively catalyze carotenoids, forming smaller apocarotenoids that are essential for the synthesis of apocarotenoid flavor, aroma volatiles, and phytohormone ABA/SLs, as well responses to abiotic stresses. Here, 19, 11, 10 CCD genes were identified in Nicotiana tabacum, tomentosiformis, sylvestris, respectively. For this family, we systematically analyzed phylogeny, gene structure, conserved motifs, duplications, cis-elements, subcellular...
Ginsenosides exhibit various neuroprotective effects against oxidative stress. However, which ginsenoside provides optimal for the treatment of neurological disorders as a potent antioxidant remains to be elucidated. Therefore, present study investigated and compared Rb1, Rd, Rg1 Re ginsenosides on neural progenitor cells (NPCs) following tert-Butylhydroperoxide (t-BHP)-induced injury. Primary rat embryonic cortical NPCs were prepared from E14.5 embryos Sprague-Dawley rats. The injury model...
Background Tumor-infiltrating lymphocytes (TILs) are considered a manifestation of the host immune response against cancer and tertiary lymphoid structures (TLS) may contribute to recruitment. Both them have been reported as potential prognostic parameters in some human malignancies. However, roles TILs, TLS, their correlation Epstein-Barr Virus-associated gastric carcinoma (EBVaGC) EBV-negative (EBVnGC) largely unknown. Methods To observe among clinicopathological characteristics...
Polyphenol-rich foods have been shown to be good for cancer prevention as powerful antioxidants. In this study, the mechanisms of wild pink bayberry free phenolic extract (WPBFE) inhibiting proliferation and inducing apoptotic MDA-MB-231 breast cells was examined. The main acids flavonols in WPBFE were gallic acid ((18.83 ± 0.44) μg/g FW) myricetin ((1.52 0.05) FW), respectively. maximum inhibition rate at non-cytotoxicity dose (below 80 mg/mL) 81 %. Western blotting analysis showed that...
Osteoporosis, a critical public health challenge, is marked by skeletal deformities and heightened fracture risk. Steleophaga plancyi (Boleny) (SP), component of traditional Chinese medicine, known to enhance bone health, but the molecular mechanisms behind its osteoprotective effects are not well understood. We isolated extracellular vesicle (EV)-like particles from SP (SP-EVLP) using differential velocity centrifugation investigated their on human marrow stromal cells (hBMSCs) in vitro....
miR152 is involved in diverse biological functions and development of disease. This study investigates the role mir-152 cell proliferation colony formation liver cancer stem cells. We show that exogenous overexpression suppresses CD133+ hep3B also KIT a direct target miR-152 downregulates protein expression by directly binding to 3′ untranslated region KIT. Downregulation specific siRNAs inhibits cells, which similar inhibitory effects miR-152. Moreover, compromises on formation. Our...
JAK2 kinase inhibitors are a promising new class of agents for the treatment myeloproliferative neoplasms and have potential other diseases possessing deregulated JAK2-STAT pathway. X-ray structure ADME guided refinement C-4 heterocycles to address metabolic liability present in dialkylthiazole 1 led discovery clinical candidate, BMS-911543 (11), with excellent kinome selectivity, vivo PD activity, safety profile.
We evaluated the efficacy of platelet‐rich plasma (PRP) in combination with allogeneic bone marrow mesenchymal stem cells (BMSCs) for treatment osteoporotic defects an ovariectomized rat model. By day 42 after injury, vivo microcomputed tomography (micro‐CT) imaging revealed that control rats and treated PRP BMSCs were completely repaired, whereas those or alone exhibited slower healing. Histological data consistent these results. also assessed changes to trabeculae proximal tibial growth...
Adult intracranial ependymomas (EPNs) are extremely rare brain tumors. Currently, clinical and molecular factors that could inform individualized treatment strategies still lacking for EPNs in this age group. The aim of study was to investigate potential prognostic indicators rational therapeutic management a large cohort adult EPNs. patients who underwent resection World Health Organization (WHO) grade II or III were included. demographic features, clinicopathologic manifestations,...
The efficacy of stem cells for the treatment renal failure is widely recognized; however, an excessive volume can block capillaries; thus, potential risks should not be ignored. Stem cell exosomes are secretory extracellular vesicles with a size 30-150 nm, which have similar functions to but much smaller in size. This study aims investigate role human umbilical cord mesenchymal (UCMSCs)-derived caused by ischemia-reperfusion. Fifty 8-week-old female C57 mice underwent bilateral...
To aim of this study is to assess the mechanism through which Desertliving Cistanche modulates PI3K/AKT signaling pathway in treatment hyperlipidemic osteoporosis ovariectomized rats.