A5017574306- Liver Disease Diagnosis and Treatment
- Non-Destructive Testing Techniques
- Ultrasonics and Acoustic Wave Propagation
- Coal Properties and Utilization
- Diet, Metabolism, and Disease
- Metabolism, Diabetes, and Cancer
- Adipose Tissue and Metabolism
- Welding Techniques and Residual Stresses
- Fibroblast Growth Factor Research
- Cancer, Hypoxia, and Metabolism
- Hydrocarbon exploration and reservoir analysis
- Peroxisome Proliferator-Activated Receptors
- Adipokines, Inflammation, and Metabolic Diseases
- Geophysical Methods and Applications
- PARP inhibition in cancer therapy
- Rock Mechanics and Modeling
- Liver physiology and pathology
- Earthquake Detection and Analysis
- Pancreatic function and diabetes
- NMR spectroscopy and applications
- Autophagy in Disease and Therapy
- Geoscience and Mining Technology
- Endoplasmic Reticulum Stress and Disease
- Metabolomics and Mass Spectrometry Studies
- DNA Repair Mechanisms
Shanghai Institute of Nutrition and Health
2018-2025
University of Chinese Academy of Sciences
2016-2025
Xi'an Jiaotong University
2019-2024
Columbia University
2022-2024
The University of Texas Southwestern Medical Center
2023-2024
China Coal Research Institute (China)
2022-2023
Chinese Academy of Sciences
2021
Shanghai Institutes for Biological Sciences
2016-2020
China University of Geosciences (Beijing)
2018-2020
Abstract Microbial metabolites have emerged as critical components that mediate the metabolic effects of gut microbiota. Here, we show indole-3-propionic acid (IPA), a tryptophan metabolite produced by bacteria, is potent anti-non-alcoholic steatohepatitis (NASH) microbial metabolite. demonstrate administration IPA modulates microbiota composition in and inhibits dysbiosis rats fed high-fat diet. induces expression tight junction proteins, such ZO-1 Occludin, maintains intestinal epithelium...
Coal and gas outbursts are dynamic disasters in which a large mass of coal suddenly emerges mining space within split second. The interaction between the pressure stress environment is one key factors that induce outbursts. In this study, first, coupling relationship body ahead working face load was investigated using experimental observations, numerical simulations, mine-site investigations. It observed impact rate on gas-bearing can significantly change pressure. faster rate, speedier...
Berberine, a compound from rhizome coptidis, is traditionally used to treat gastrointestinal infections, such as bacterial diarrhoea. Recently, berberine was shown have hypoglycaemic and hypolipidaemic effects. We investigated the mechanisms by which regulates hepatic lipid metabolism energy expenditure in mice.Liver-specific SIRT1 knockout mice their wild-type littermates were fed high-fat, high-sucrose (HFHS) diet treated with i.p. injection for five weeks. Mouse primary hepatocytes human...
Abstract Insulin-induced gene (Insig) negatively regulates SREBP-mediated de novo fatty acid synthesis in the liver. However, upstream regulation of Insig is incompletely understood. Here we report that AMPK interacts with and mediates phosphorylation Insig. Thr222 following activation required for protein stabilization Insig-1, inhibition cleavage processing SREBP-1, lipogenic expression response to metformin or A769662. AMPK-dependent ablates Insig’s interaction E3 ubiquitin ligase gp78...
The endoplasmic reticulum quality control protein activating transcription factor 6 (ATF6) has emerged as a novel metabolic regulator. Here, we show that adenovirus-mediated overexpression of the dominant-negative form ATF6 (dnATF6) increases susceptibility to develop hepatic steatosis in diet-induced insulin-resistant mice and fasted mice. Overexpression dnATF6 or small interfering RNA-mediated knockdown decreases transcriptional activity peroxisome proliferator-activated receptor α...
Butyric acid is an intestinal microbiota-produced short-chain fatty acid, which exerts salutary effects on alleviating nonalcoholic liver disease (NAFLD). However, the underlying mechanism of butyrate regulating hepatic lipid metabolism largely unexplored.A mouse model NAFLD was induced with high-fat diet feeding, and sodium (NaB) intervention initiated at eighth week lasted for 8 weeks. Hepatic steatosis evaluated metabolic pathways concerning homeostasis were analyzed.Here, we report that...
Background and Aims Fibroblast growth factor (FGF) 1 demonstrated protection against nonalcoholic fatty liver disease (NAFLD) in type 2 diabetic obese mice by an uncertain mechanism. This study investigated the therapeutic activity mechanism of a nonmitogenic FGF1 variant carrying 3 substitutions heparin‐binding sites (FGF1 △HBS ) NAFLD. Approach Results administration was effective 9‐month‐old homozygous mutation leptin receptor gene ( db/db with NAFLD; weight, lipid deposition,...
Recent studies have pointed to PARP1 trapping as a key determinant of the anticancer effects inhibitors (PARPi). We identified RNF114, PARylation-dependent, E3 ubiquitin ligase involved in DNA damage response. Upon sensing genotoxicity, RNF114 was recruited, PAR-dependent manner, lesions, where it targeted for degradation. The blockade this pathway interfered with removal from leading profound trapping. showed that natural product, nimbolide, inhibited activity and thus caused However,...
BackgroundNonalcoholic fatty liver disease (NAFLD) is associated with altered production of secreted proteins. Increased understanding proteins could lead to improved prediction and treatment NAFLD. Here, we aimed discover novel in humans that are hepatic fat content using unbiased proteomic profiling strategy, how the identified Thbs1 modulates lipid metabolism steatosis.MethodNAFLD patients were enrolled treated lifestyle intervention. Patients who underwent biopsy for analyzing...
Nonalcoholic steatohepatitis has emerged as a major cause of liver diseases with no effective therapies. Here, we evaluate the efficacies and pharmacokinetics B1344, long-acting polyethylene glycolylated (PEGylated) fibroblast growth factor 21 analog, in nongenetically modified nonhuman primate species that underwent biopsy demonstrate potential for humans. B1344 is sufficient to selectively activate signaling from βKlotho/FGFR1c receptor complex. In cynomolgus monkeys nonalcoholic fatty...
STAT3, a member of the signal transducer and activator transcription (STAT) family, is strongly associated with liver injury, inflammation, regeneration, hepatocellular carcinoma development. However, signals that regulate STAT3 activity are not completely understood.Here we characterize CREB/ATF bZIP factor CREBZF as critical regulator in hepatocyte to repress regeneration. We show deficiency stimulates expression cyclin gene family enhances regeneration after partial hepatectomy. Flow...
Although BRCA1/2 mutations are not commonly found in small cell lung cancer (SCLC), a substantial fraction of SCLC shows clinically relevant response to PARP inhibitors (PARPis). However, the underlying mechanism(s) PARPi sensitivity is poorly understood. We performed quantitative proteomic analyses and identified changes that signify responses cells. vulnerability could be explained by degradation lineage-specific oncoproteins (e.g., ASCL1). PARPi-induced activation E3 ligase HUWE1 mediated...
The effective stress plays an essential role in predicting the permeability of coal reservoir during coalbed methane (CBM) production. However, importance coefficient (ESC) for evolution has always been neglected. In this work, a series measurements were performed on cores different directions under constant confining pressure (CCP) conditions and pore to demonstrate sensitivities anisotropic pressure. Under CCP conditions, loading unloading results show that irreversible loss rate vertical...
Background and Aims: NASH has emerged as a leading cause of chronic liver disease. However, the mechanisms that govern fibrosis remain largely unknown. CREBZF is CREB/ATF bZIP transcription factor causes hepatic steatosis metabolic defects in obesity. Approach Results: Here, we show key mechanism checkpoint promotes hepatocyte injury exacerbates diet-induced mice. deficiency attenuated injury, fibrosis, inflammation mouse models NASH. increases HSC activation hepatocyte-autonomous manner by...
Abstract Chronic adipose tissue inflammation accompanied by macrophage accumulation and activation is implicated in the pathogenesis of insulin resistance type 2 diabetes humans. The transcriptional coregulator CREBZF a key factor hepatic metabolism, yet its role modulating remains elusive. present study demonstrates that overnutrition‐induced links (ATM) proinflammatory to resistance. deficiency macrophages, not neutrophils, attenuates infiltration adipose, activation, hyperglycemia...