A5074869640- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Metabolism, Diabetes, and Cancer
- Adipose Tissue and Metabolism
- Fibroblast Growth Factor Research
- Adipokines, Inflammation, and Metabolic Diseases
- Pancreatic function and diabetes
- Peroxisome Proliferator-Activated Receptors
- Cancer, Hypoxia, and Metabolism
- Autophagy in Disease and Therapy
- Liver physiology and pathology
- Hepatitis B Virus Studies
- Advanced Glycation End Products research
- Tea Polyphenols and Effects
- Protein Hydrolysis and Bioactive Peptides
- Diet and metabolism studies
- Gut microbiota and health
- Endoplasmic Reticulum Stress and Disease
- Botanical Research and Applications
- Regulation of Appetite and Obesity
- Pickering emulsions and particle stabilization
- Adenosine and Purinergic Signaling
- Metabolomics and Mass Spectrometry Studies
- Kruppel-like factors research
- Nanocomposite Films for Food Packaging
Shanghai Institute of Nutrition and Health
2018-2025
University of Chinese Academy of Sciences
2017-2025
Nanjing Agricultural University
2015-2025
Chinese Academy of Sciences
2021
Shanghai Institutes for Biological Sciences
2017-2020
Abstract Microbial metabolites have emerged as critical components that mediate the metabolic effects of gut microbiota. Here, we show indole-3-propionic acid (IPA), a tryptophan metabolite produced by bacteria, is potent anti-non-alcoholic steatohepatitis (NASH) microbial metabolite. demonstrate administration IPA modulates microbiota composition in and inhibits dysbiosis rats fed high-fat diet. induces expression tight junction proteins, such ZO-1 Occludin, maintains intestinal epithelium...
Berberine, a compound from rhizome coptidis, is traditionally used to treat gastrointestinal infections, such as bacterial diarrhoea. Recently, berberine was shown have hypoglycaemic and hypolipidaemic effects. We investigated the mechanisms by which regulates hepatic lipid metabolism energy expenditure in mice.Liver-specific SIRT1 knockout mice their wild-type littermates were fed high-fat, high-sucrose (HFHS) diet treated with i.p. injection for five weeks. Mouse primary hepatocytes human...
Abstract Insulin-induced gene (Insig) negatively regulates SREBP-mediated de novo fatty acid synthesis in the liver. However, upstream regulation of Insig is incompletely understood. Here we report that AMPK interacts with and mediates phosphorylation Insig. Thr222 following activation required for protein stabilization Insig-1, inhibition cleavage processing SREBP-1, lipogenic expression response to metformin or A769662. AMPK-dependent ablates Insig’s interaction E3 ubiquitin ligase gp78...
Butyric acid is an intestinal microbiota-produced short-chain fatty acid, which exerts salutary effects on alleviating nonalcoholic liver disease (NAFLD). However, the underlying mechanism of butyrate regulating hepatic lipid metabolism largely unexplored.A mouse model NAFLD was induced with high-fat diet feeding, and sodium (NaB) intervention initiated at eighth week lasted for 8 weeks. Hepatic steatosis evaluated metabolic pathways concerning homeostasis were analyzed.Here, we report that...
Normal metabolism requires a controlled balance between anabolism and catabolism. It is not completely known how this can be retained when the level of nutrient supply changes in long term. We found that murine liver anabolism, as represented by phosphorylation RPS6KB (ribosomal protein S6 kinase), was soon elevated while catabolism, TFEB (transcription factor EB)-directed gene transcription lysosomal activities, downregulated after administration high-fat diet (HFD). Surprisingly, neither...
Obesity and related inflammation are critical for the pathogenesis of insulin resistance, but underlying mechanisms not fully understood. Formyl peptide receptor 2 (FPR2) plays important roles in host immune responses inflammation-related diseases. We found that Fpr2 expression was elevated white adipose tissue high-fat diet (HFD)–induced obese mice db/db mice. The systemic deletion alleviated HFD-induced obesity, hyperglycemia, hyperlipidemia, hepatic steatosis. Furthermore, HFD-fed body...
BackgroundNonalcoholic fatty liver disease (NAFLD) is associated with altered production of secreted proteins. Increased understanding proteins could lead to improved prediction and treatment NAFLD. Here, we aimed discover novel in humans that are hepatic fat content using unbiased proteomic profiling strategy, how the identified Thbs1 modulates lipid metabolism steatosis.MethodNAFLD patients were enrolled treated lifestyle intervention. Patients who underwent biopsy for analyzing...
Nonalcoholic steatohepatitis has emerged as a major cause of liver diseases with no effective therapies. Here, we evaluate the efficacies and pharmacokinetics B1344, long-acting polyethylene glycolylated (PEGylated) fibroblast growth factor 21 analog, in nongenetically modified nonhuman primate species that underwent biopsy demonstrate potential for humans. B1344 is sufficient to selectively activate signaling from βKlotho/FGFR1c receptor complex. In cynomolgus monkeys nonalcoholic fatty...
STAT3, a member of the signal transducer and activator transcription (STAT) family, is strongly associated with liver injury, inflammation, regeneration, hepatocellular carcinoma development. However, signals that regulate STAT3 activity are not completely understood.Here we characterize CREB/ATF bZIP factor CREBZF as critical regulator in hepatocyte to repress regeneration. We show deficiency stimulates expression cyclin gene family enhances regeneration after partial hepatectomy. Flow...
Insulin is critical for the regulation of de novo fatty acid synthesis, which converts glucose to lipid in liver. However, how insulin signals are transduced into cell and then regulate lipogenesis remains be fully understood. Here, we identified CREB/ATF bZIP transcription factor (CREBZF) activating factor/cAMP response element‐binding protein (ATF/CREB) gene family as a key regulator through insulin‐Akt signaling. Insulin‐induced 2a (Insig‐2a) decreases during refeeding, allowing sterol...
Modification of chitosan (CS) through grafting with caffeic acid (CA, CA-g-CS) and ferulic (FA, FA-g-CS) significantly improved its solubility under neutral alkaline environments. Spherical physicochemically stable nanocomplexes assembled from the phenolic CS caseinophosphopeptide (CPP) were obtained particle size <300 nm zeta potential <+30 mV. The net polymer composed CPP showed strong antioxidant activity. encapsulation efficiencies epigallocatechin-3-gallate (EGCG) in CA-g-CS-CPP...
Background and Aims: NASH has emerged as a leading cause of chronic liver disease. However, the mechanisms that govern fibrosis remain largely unknown. CREBZF is CREB/ATF bZIP transcription factor causes hepatic steatosis metabolic defects in obesity. Approach Results: Here, we show key mechanism checkpoint promotes hepatocyte injury exacerbates diet-induced mice. deficiency attenuated injury, fibrosis, inflammation mouse models NASH. increases HSC activation hepatocyte-autonomous manner by...
Obesity is becoming a worldwide pandemic. Interfacial engineering of food lipid expected to inhibit diet-induced obesity without damage the eating enjoyment brought by high-fat diets. Unfortunately, this strategy has not been achieved yet. After screening different plant proteins, bromelain and papain were found form wormlike long-straight protein fibrils, respectively. The conversion amyloid-like fibrils was demonstrated in fibrillation bromelain. Using oil-in-water high internal phase...
Prolyl hydroxylase domain (PHD) enzymes change HIF activity according to oxygen signal; whether it is regulated by other physiological conditions remains largely unknown. Here, we report that PHD3 induced fasting and regulates hepatic gluconeogenesis through interaction hydroxylation of CRTC2. Pro129 Pro615 CRTC2 following activation necessary for its association with cAMP-response element binding protein (CREB) nuclear translocation, enhanced promoters gluconeogenic genes or forskolin....
Nonalcoholic steatohepatitis has emerged as a major cause of liver diseases with no effective therapies. Here, we evaluate the efficacies and pharmacokinetics B1344, long-acting PEGylated FGF21 analog, in nongenetically modified nonhuman primate species that underwent biopsy, demonstrate potential for humans. B1344 is sufficient to selectively activate signaling from βKlotho/FGFR1c receptor complex. In cynomolgus monkeys nonalcoholic fatty disease, administration via subcutaneous injection...
Obesity and type 2 diabetes are associated with chronic inflammation response in the adipose tissue, which macrophage activation infiltration hallmark characteristics. However, molecular mechanism of this association remains largely unknown. Here, we show that CREB/ATF bZIP transcription factor CREBZF as a critical regulator sensing inflammatory signals to cause systemic insulin resistance obesity. We found was markedly induced bone-marrow-derived macrophages J774 cell lines...
Although glucose is generally considered to be required for generating heat during cold-induced nonshivering thermogenesis in the adipose tissue, whether it engages nutrient sensing pathways tissue negatively regulate and impairs metabolic homeostasis remains largely unknown. Here we report CREB/ATF bZIP transcription factor CREBZF as a key target of adipocyte signaling that exerts negative effect on adaptive tissue. We found was significantly induced inguinal white (iWAT) response cold...
Nonalcoholic steatohepatitis has emerged as a major cause of liver diseases with no effective therapies. Here, we evaluate the efficacies and pharmacokinetics B1344, long-acting PEGylated FGF21 analog, in nongenetically modified nonhuman primate species that underwent biopsy, demonstrate potential for humans. B1344 is sufficient to selectively activate signaling from βKlotho/FGFR1c receptor complex. In cynomolgus monkeys nonalcoholic fatty disease, administration via subcutaneous injection...
Glucose uptake is highly induced during cold exposure or feeding in adipocytes, which utilized as an important energy source for most cells. However, little known about whether glucose regulates downstream targets that govern thermogenesis and metabolic homeostasis adipose tissue. Here, we characterize CREB/ATF bZIP transcription factor CREBZF a novel sensor via acetylation adipocytes. Proteomic analysis using LC-MS/MS identifies Lys126 evolutionally conserved residue acetylated...
Nonalcoholic steatohepatitis (NASH) is becoming a major cause of liver diseases with no effective drugs in the clinic. Fibroblast growth factor 21 (FGF-21) has emerged as potent metabolic regulator therapeutic prospect to lipids and NASH animal models preclinical trials. FGF-21 agents mimicking its activity may be developed into pharmacotherapeutic targets for treatment. Here, we show that B1344, site-specific PEGylated human analog, shifts physiology mice or cynomolgus monkeys towards...