A5021067194- Metabolism, Diabetes, and Cancer
- Diet and metabolism studies
- Advanced Glycation End Products research
- Diabetes Treatment and Management
- Diet, Metabolism, and Disease
- Inflammasome and immune disorders
- Pancreatic function and diabetes
- Biochemical Analysis and Sensing Techniques
- IL-33, ST2, and ILC Pathways
- Chronic Kidney Disease and Diabetes
- Cancer, Hypoxia, and Metabolism
- Ubiquitin and proteasome pathways
- TGF-β signaling in diseases
- Adipose Tissue and Metabolism
- Cholesterol and Lipid Metabolism
- Receptor Mechanisms and Signaling
- Adipokines, Inflammation, and Metabolic Diseases
- Epigenetics and DNA Methylation
- NF-κB Signaling Pathways
- Immune Cell Function and Interaction
- Dialysis and Renal Disease Management
- Nuclear Receptors and Signaling
- Renin-Angiotensin System Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Microbial Metabolites in Food Biotechnology
Affiliated Hospital of Southwest Medical University
2017-2025
Xuzhou Medical College
2024
First Affiliated Hospital of Sichuan Medical University
2012-2024
Shanghai Clinical Research Center
2022-2023
Macau University of Science and Technology
2017-2021
University of Macau
2018-2019
Southwest Medical University
2012-2016
Beijing University of Chinese Medicine
2008
California Wellness Foundation
2008
Diabetic nephropathy (DN) is a chronic low-grade inflammatory disease. Oxidative stress and nuclear factor kappa B (NF- κ B) signaling play an important role in the pathogenesis of DN. Short-chain fatty acids (SCFAs) produced from carbohydrate fermentation gastrointestinal tract exert positive regulatory effects on inflammation kidney injuries. However, it unclear whether SCFAs can prevent ameliorate In present study, we evaluated mechanism three main (acetate, propionate, butyrate) high-fat...
Endotoxemia has been recognized to be closely accompanied with type 2 diabetes mellitus (T2DM) and is responsible for many diabetic complications. Recent study suggests the potential role of butyrate, a short-chain fatty acid (SCFA) from microbiota metabolite, on T2DM. Gut-leak key event in diabetic-endotoxemia. To investigate if butyrate could ameliorate diabetic-endotoxemia, both vivo vitro experiments were carried out present study. The effect supplementation blood HbA1c inflammatory...
While inflammation is considered a central component in the development diabetic nephropathy, mechanism remains unclear. The NLRP3 inflammasome acts as both sensor and regulator of inflammatory response. responds to exogenous endogenous danger signals, resulting cleavage procaspase-1 activation cytokines IL-1β, IL-18, IL-33, ultimately triggering an cascade reaction. This study observed expression signaling stimulated by high glucose, lipopolysaccharide, reactive oxygen species (ROS)...
Liver plays a central role in modulating blood glucose level. Our most recent findings suggested that supplementation with microbiota metabolite sodium butyrate (NaB) could ameliorate progression of type 2 diabetes mellitus (T2DM) and decrease HbA1c db/db mice. To further investigate the homeostasis glycogen metabolism, we carried out present study. In mice, found significant hypertrophy steatosis hepatic lobules accompanied by reduced storage, expression GPR43 was significantly decreased...
Inflammation and fibrosis are the important pathophysiologic processes in diabetic kidney disease (DKD), which is induced by epigenetics, especially histone posttranslational modification (HPTMs). Recent reports highlighted that butyrate, one of short-chain fatty acids (SCFAs) primarily originated from fermentation dietary fiber gut, attenuates inflammation prevention treatment DKD; however, molecular mechanisms still unclear. Histone lysine butyrylation (Kbu), a novel marker has been found...
A ketogenic diet (KD) and β-hydroxybutyrate (βOHB) have been widely reported as effective therapies for metabolic diseases.β-Hydroxybutyrate dehydrogenase 1 (BDH1) is the rate-limiting enzyme in ketone metabolism.In this study, we examined BDH1-mediated βOHB pathway pathogenesis of diabetic kidney disease (DKD).We found that BDH1 downregulated kidneys DKD mouse models, patients with diabetes, high glucose-or palmitic acid-induced human renal tubular epithelial (HK-2) cells.BDH1...
Alcoholic fatty liver disease (AFLD) is characterized by hepatic steatosis and carries an elevated risk of cirrhosis hepatocellular carcinoma. However, the mechanism AFLD has not been elucidated thoroughly, there are still no efficient therapies in clinic. Notably, butyrate, one kind short-chain acids produced gut microbiota, shown to improve methionine-choline-deficient diet-induced non-alcoholic steatohepatitis. And our previous study found that butyrate ameliorated endotoxemia db/db mice....
Background . Inflammation and fibrosis are the important pathophysiologic processes in diabetic nephropathy (DN). Maresin 1 is a potential anti-inflammatory lipid mediator, which has displayed powerful proresolving activities. Aim We determine whether maresin protective effect on mouse glomerular mesangial cells (GMCs) induced by high glucose. Methods cultured GMCs stimulated glucose categorized as follows: normal group (5.6 mmol/L), (30 mannitol group, intervention (1, 10, 100 nmol/L),...
Background . Hyperglycemia plays a pivotal role in the development of diabetic nephropathy (DN) and may be related to epigenetic metabolic memory. One most crucial mechanisms is histone modification, which associated with expression fibrosis factor vascular injury. Aim .In this study, we investigated ubiquitination histones H2A H2B explore DN. Materials Methods The GMCs were cultured as follows: normal group, high glucose mannitol intervention group. After 12 hr, 24 48 ubiquitination,...
Previous studies demonstrated that ROS-NLRP3 inflammasome signaling activation was involved in the pathogenesis of diabetic nephropathy (DN). Recent research has shown sweet taste receptors (STRs) are important sentinels innate immunity. Whether high glucose primes via STRs is unclear. In this study, mouse model induced by streptozotocin (STZ) vivo; glomerular mesangial cells (GMCs) and human proximal tubular were stimulated (10, 20, 30 mmol/L) vitro; STR inhibitor lactisole used as an...
Background . Smad7 is the main negative regulatory protein in transforming growth factor- β (TGF- ) downstream signaling pathway, which plays an important role diabetic nephropathy (DN) and may be related to ubiquitin proteasome pathway (UPP). Aim We investigated of UPP regulating TGF- /SMAD explored therapeutic effect inhibitor MG132 on DN. Methods Wistar rats were randomly divided into a diabetes group normal control group. Rats injected intraperitoneally with streptozotocin. Diabetic then...